CAS 29110-48-3

Cloridrato de guanfacina

Descrição:

Cloridrato de guanfacina é um medicamento usado principalmente para tratar o transtorno do déficit de atenção com hiperatividade (TDAH) e hipertensão. É um agonista alfa-2 adrenérgico, o que significa que atua estimulando os receptores alfa-2 no cérebro, levando a uma diminuição do fluxo simpático e à redução da pressão arterial. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, tornando-a adequada para administração oral. Sua fórmula química é C9H9ClN2 e tem um peso molecular de aproximadamente 182,63 g/mol. Cloridrato de guanfacina é conhecido por seus efeitos sedativos, que podem ser benéficos no manejo dos sintomas do TDAH, promovendo calma e foco. O medicamento é tipicamente administrado em forma de comprimidos, com a dosagem ajustada com base na resposta e tolerância do paciente individual. Efeitos colaterais comuns podem incluir sonolência, boca seca e fadiga. Assim como com qualquer medicamento, é essencial usar Cloridrato de guanfacina sob a orientação de um profissional de saúde para garantir segurança e eficácia.

Fórmula: C₉H₁₀Cl₃N₃O

InChI: InChI=1/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

Chave InChI: InChIKey=DGFYECXYGUIODH-UHFFFAOYSA-N

SMILES: C(C(NC(=N)N)=O)C1=C(Cl)C=CC=C1Cl.Cl

Sinónimos:

• 2,6-Dichlorophenylacetylguanidine hydrochloride
• Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1)
• Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, monohydrochloride
• Bs 100-141
• Estulic
• Guanfacine HCl
• Guanfacine hydrochloride [USAN:JAN]
• Intuniv
• Lon 798
• N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride
• N-(Aminoiminomethyl)-2,6-dichlorophenylacetamide monohydrochloride
• N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride
• N-Amidino-2-(2,6-dichlorophenyl)acetamide monohydrochloride
• Spd 503
• Tenex
• Tenex (pharmaceutical)
• Unii-Pml56A160O
• [(2,6-Dichlorophenyl)acetyl]guanidine monohydrochloride
• n-(aminoiminomethyl)-2,6-dichlorobenzeneacetamidehydrochloride
• [(2,6-DICHLOROPHENYL)ACETYL]GUANIDINE HYDROCHLORIDE
• N (AMINOIMINOMETHYL)-2,6-DICHLOROBENZENEACETAMIDE HYDROCHLORIDE SALT
• Guarfacine
• Guanfascine
• GUANFACINE HYDROCHLORIDE
• GUANFACIN HYDROCHLORIDE
• n-(aminoiminomethyl)-2,6-dichloro-benzeneacetamidmonohydrochloride
• n-amidino-2-(2,6-dichlorophenyl)acetamidehydrochloride
• bs100-141
• lon798

Guanfacine Hydrochloride

CAS: 29110-48-3

Aromatic imines and their derivatives, salts thereof

Fórmula: C₉H₉Cl₂N₃O·HCI

Cor e Forma: White Off-White Crystalline Powder

Peso molecular: 384.92456

Ref: 45-1302101

Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1)

CAS: 29110-48-3

Fórmula: C₉H₁₀Cl₃N₃O

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 282.5542

Ref: IN-DA002XC9

N-Carbamimidoyl-2-(2,6-Dichlorophenyl)Acetamide Hydrochloride

CAS: 29110-48-3

N-Carbamimidoyl-2-(2,6-Dichlorophenyl)Acetamide Hydrochloride

Pureza: 99%

Peso molecular: 282.55g/mol

Ref: 54-OR1014312

Guanfacine hydrochloride

CAS: 29110-48-3

Guanfacine hydrochloride

Pureza: ≥98%

Peso molecular: 282.55g/mol

Ref: 54-BUP13678

Guanfacine HCl

CAS: 29110-48-3

Fórmula: C₉H₉Cl₂N₃O·HCl

Cor e Forma: Off-White Solid

Peso molecular: 246.09 36.46

Ref: 4Z-G-184

Guanfacine Hydrochloride

CAS: 29110-47-2, 29110-48-3

Fórmula: C₉H₉Cl₂N₃O·HCl

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 282.55

Ref: 3B-G0414

Guanfacine hydrochloride

CAS: 29110-48-3

Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.

Fórmula: C₉H₁₀Cl₃N₃O

Pureza: 99.89% - 99.91%

Cor e Forma: Solid

Peso molecular: 282.55

Ref: TM-T2150

Guanfacine hydrochloride

CAS: 29110-48-3

Fórmula: C₉H₉Cl₂N₃O·HCl

Pureza: ≥ 98.0%

Cor e Forma: White to almost white crystalline powder

Peso molecular: 282.55

Ref: 7W-GP1667

Guanfacine Hydrochloride

CAS: 29110-48-3

Fórmula: C₉H₉Cl₂N₃O·ClH

Cor e Forma: Neat

Peso molecular: 282.55

Ref: TR-G816001

N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride

CAS: 29110-48-3

Fórmula: C₉H₁₀Cl₃N₃O

Pureza: 99%

Peso molecular: 282.55

Ref: 10-F234921

Guanfacine HCl

CAS: 29110-48-3

Guanfacine is a centrally acting alpha-2 adrenergic agonist that is used in the treatment of hypertension and attention deficit hyperactivity disorder (ADHD). It is a racemic mixture of two enantiomers, (+) and (-) guanfacine. Guanfacine acts on central alpha-2 receptors to reduce sympathetic outflow from the vasomotor center, which leads to reduced peripheral vascular resistance, decreased blood pressure, and increased heart rate. It also has been shown to increase the release of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits neuronal activity. Guanfacine is metabolized by CYP3A4 and CYP2D6 enzymes with elimination half-life of 10 hours. The drug has minimal drug interactions due to its low protein binding properties. Guanfacine has been found to be safe for use in humans at doses up to 3 mg/kg/day

Fórmula: C₉H₉Cl₂N₃O·HCl

Pureza: Min. 95%

Peso molecular: 282.55 g/mol

Ref: 3D-FG33962