CAS 2926610-43-5

TQ-3959

CAS: 2926610-43-5

TQ-3959 is an orally active BTKPROTAC degrader, with a DC50 of 14.6 nM. It exhibits antiproliferative activity against both wild-type BTK and BTK C481S mutant cell lines. TQ-3959 demonstrates tumor growth inhibition in female NOD-SCID mice with TMD-8 xenografts. This compound is applicable in the study of B-cell malignancies, such as lymphoma.

Fórmula: C₄₀H₄₇N₁₁O₅

Cor e Forma: Solid

Peso molecular: 761.87

Ref: TM-T212293