CAS 29782-68-1

Silidianina

Descrição:

Silidianina é um composto de flavonolignano derivado principalmente da planta cardo mariano, Silybum marianum. É um dos constituintes ativos da silimarina, um complexo de flavonoides conhecido por suas propriedades hepatoprotetoras. Silidianina exibe atividade antioxidante, o que ajuda a neutralizar radicais livres e reduzir o estresse oxidativo nas células do fígado. Este composto é frequentemente estudado por seus potenciais efeitos terapêuticos em doenças hepáticas, incluindo hepatite e cirrose, pois pode promover a regeneração do fígado e melhorar a função hepática. Além disso, Silidianina tem sido investigado por seus efeitos anti-inflamatórios e citoprotetores, contribuindo para seus benefícios gerais à saúde. A substância é tipicamente caracterizada por sua solubilidade em solventes orgânicos e solubilidade limitada em água, o que é comum para muitos flavonoides. Suas propriedades farmacológicas e perfil de segurança fazem dela um assunto de interesse na medicina herbal e em suplementos dietéticos voltados para o suporte à saúde do fígado.

Fórmula: C₂₅H₂₂O₁₀

InChI: InChI=1S/C25H22O10/c1-33-16-4-9(2-3-14(16)27)18-11-7-12(20-13(18)8-34-25(20,32)24(11)31)23-22(30)21(29)19-15(28)5-10(26)6-17(19)35-23/h2-7,11,13,18,20,22-23,26-28,30,32H,8H2,1H3/t11-,13-,18+,20+,22+,23-,25-/m1/s1

Chave InChI: InChIKey=CYGIJEJDYJOUAN-JSGXPVSSSA-N

SMILES: O[C@@]12[C@@]3([C@@]([C@H]([C@@](C=C3[C@H]4OC=5C(C(=O)[C@@H]4O)=C(O)C=C(O)C5)(C1=O)[H])C6=CC(OC)=C(O)C=C6)(CO2)[H])[H]

Sinónimos:

• (+)-2,3alpha,3aalpha,7a-Tetrahydro-7aalpha-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3alpha,5,7-trihydroxy-4-oxo-2beta-chromanyl)-3,6-methanobenzofuran-7(6alphaH)-one
• (3R,3aR,6R,7aR)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R,3R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• 3,6-Methanobenzofuran-7(6H)-one, 4-(3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, [3R-[3α,3aβ,4(2R*,3R*),6α,7aβ,8R*]]-
• 3,6-Methanobenzofuran-7(6H)-one, 4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, (3R,3aR,6R,7aR,8R)-
• 3,6-Methanobenzofuran-7(6αH)-one, 2,3α,3aα,7a-tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-, (+)-
• 7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• Silidianin [INN]
• Silidianina
• Silidianina [INN-Spanish]
• Silidianine
• Silidianine [INN-French]
• Silidianinum
• Silidianinum [INN-Latin]

Silydianin

CAS: 29782-68-1

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₂₅H₂₂O₁₀

Cor e Forma: Yellow Powder

Peso molecular: 482.1213

Ref: 45-1612641

Silydianin

CAS: 29782-68-1

Fórmula: C₂₅H₂₂O₁₀

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 482.4362

Ref: IN-DA00BE5C

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

CAS: 29782-68-1

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

Pureza: 95%

Peso molecular: 482.44g/mol

Ref: 54-OR1023990

Silydianin

CAS: 29782-68-1

Silydianin

Pureza: ≥95%

Peso molecular: 482.44g/mol

Ref: 54-BUP02913

Silydianin

CAS: 29782-68-1

Fórmula: C₂₅H₂₂O₁₀

Peso molecular: 482.44

Ref: 7W-GY6531

Silydianin

CAS: 29782-68-1

Silydianin, an active constituent of Silybium marianum, has inhibitory effect on on the in vitro production and release of oxidative products. Silydianin has possible antiinflammatory activity, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.

Fórmula: C₂₅H₂₂O₁₀

Pureza: 95%~99%

Peso molecular: 482.441

Ref: BP-BP1307

Silydianin

CAS: 29782-68-1

Fórmula: C₂₅H₂₂O₁₀

Peso molecular: 482.45

Ref: 4Z-S-398

Silydianin

CAS: 29782-68-1

Silydianin inhibits UGT, OATP1B1, OATP1B3 in HEK293 cells, and OATP2B1 in MDCK2 cells.

Fórmula: C₂₅H₂₂O₁₀

Pureza: 98.01% - 98.56%

Cor e Forma: Solid

Peso molecular: 482.44

Ref: TM-T3880

Silydianin

CAS: 29782-68-1

Oxygen-heterocyclic compound

Fórmula: C₂₅H₂₂O₁₀

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 482.44

Ref: 5G-89282

Silydianin

Produto Controlado

CAS: 29782-68-1

Applications Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.
References Zlelinska-Przyyjemska, M., et al.: Phytother. Res., 20, 115 (2006); Milan, M., et al.L Anal. Chimica. Acta., 486, 125 (2003); Liu, Y.Z., et al.: Chin. Herb. Med., 4, 237 (2012);

Fórmula: C₂₅H₂₂O₁₀

Cor e Forma: Off-White

Peso molecular: 482.44

Ref: TR-S465890

Silydianin

CAS: 29782-68-1

Silydianin is a flavonolignan compound, which is derived from the seeds of the milk thistle plant, Silybum marianum. Its primary mode of action involves antioxidant properties and inhibition of lipid peroxidation. Silydianin contributes to the stabilization of cell membranes, thereby preventing toxins from entering liver cells, and also stimulates the activity of ribosomal RNA, promoting liver cell regeneration.

Fórmula: C₂₅H₂₂O₁₀

Pureza: Min. 95.0 Area-%

Peso molecular: 482.44 g/mol

Ref: 3D-FS42773