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CAS 3025180-14-4

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  • Microtubulin-IN-1
    Targetmol
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    Microtubulin-IN-1

    CAS:
    <p>Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.</p>
    Fórmula:C25H21FN4O3
    Cor e Forma:Solid
    Peso molecular:444.458

    Ref: TM-T206493