CAS 3031-95-6

SAICAR

Descrição:

SAICAR, ou N-succinil-5-aminoimidazol-4-carboxamida ribonucleotídeo, é um composto químico envolvido na via de biossíntese de purinas. É caracterizado pelo seu papel como um intermediário na síntese de nucleotídeos de purina, especificamente na conversão de aminoácidos e outros substratos em nucleotídeos de adenina e guanina. O composto apresenta uma estrutura de ribonucleotídeo, que inclui um açúcar ribose, um grupo carboxamida e um moiety succinilo. SAICAR é tipicamente encontrado em sistemas biológicos, particularmente em organismos que utilizam a via de novo para a síntese de nucleotídeos. Seu número CAS, 3031-95-6, é um identificador único que facilita a identificação e o estudo deste composto na literatura científica e em bancos de dados. O composto é de interesse na pesquisa bioquímica, particularmente em estudos relacionados a vias metabólicas e funções enzimáticas. Compreender as características de SAICAR e seu papel no metabolismo pode fornecer insights sobre processos celulares e potenciais alvos terapêuticos em doenças relacionadas ao metabolismo de nucleotídeos.

Fórmula: C₁₃H₁₉N₄O₁₂P

InChI: InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1

Chave InChI: InChIKey=NAQGHJTUZRHGAC-ZZZDFHIKSA-N

SMILES: NC=1N(C=NC1C(N[C@@H](CC(O)=O)C(O)=O)=O)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O

Sinónimos:

• 3031-95-6
• 5-Amino-4-imidazole-N-succinocarboxamide ribonucleotide
• 5-Amino-N-(1,2-dicarboxyethyl)-1-ribofuranosylimidazole-4-carboxamide 5'-Phosphate
• <span class="text-smallcaps">L</smallcap>-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-<smallcap>D</span>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• Aspartic acid, N-[(5-amino-1-β-<span class="text-smallcaps">D</smallcap>-ribofuranosylimidazol-4-yl)carbonyl]-, 5′-(dihydrogen phosphate), <smallcap>L</span>-
• L-aspartic acid, N-[[5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• N-(5-Amino-1-ribofuranosylimidazol-4-ylcarbonyl)aspartic acid 5′-phosphate
• N-[(5-Amino-1-ribofuranosylimidazol-4-yl)carbonyl]aspartic Acid 5'-Phosphate
• N-[5-Amino-1-(5'-phosphoribofuranosyl)-4-imidazolecarbonyl]aspartic Acid
• N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic Acid
• N-[[5-Amino-1-(5-O-phosphono-β-<span class="text-smallcaps">D</smallcap>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-<smallcap>L</span>-aspartic acid
• Saicar
• Succino-AICAR
• L-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• Aspartic acid, N-[(5-amino-1-β-D-ribofuranosylimidazol-4-yl)carbonyl]-, 5′-(dihydrogen phosphate), L-

N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazoL-4-yl]carbonyl]-L-aspartic acid

CAS: 3031-95-6

Fórmula: C₁₃H₁₉N₄O₁₂P

Cor e Forma: Solid

Peso molecular: 454.2833

Ref: IN-DA002ZMH

SAICAR

CAS: 3031-95-6

SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).

Fórmula: C₁₃H₁₉N₄O₁₂P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 454.28

Ref: TM-T16837

N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate

CAS: 3031-95-6

Applications N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate is a metabolite of Purine. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

Fórmula: C₁₃H₁₉N₄O₁₂P

Cor e Forma: Neat

Peso molecular: 454.28

Ref: TR-S688795

N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate

CAS: 3031-95-6

N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate is a synthetase that is involved in the biosynthesis of purines and pyrimidines. It catalyzes the ATP-dependent formation of N-succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate from succinyl CoA and aspartic acid. This enzyme has been studied in wild type strains of bacteria, such as Escherichia coli, but not in humans or other organisms. N-Succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate has been shown to be an inhibitor of antimicrobial agents such as penicillin G, erythromycin, and tetracycline. The mechanism for this inhibition is unclear, but it may involve hydrogen bonding interactions or structural changes that prevent binding

Fórmula: C₁₃H₁₉N₄O₁₂P

Pureza: Min. 95 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 454.28 g/mol

Ref: 3D-NS166064