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CAS 3043797-88-9

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  • Lysosomal P-gp targeted agent 1
    Targetmol
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    Lysosomal P-gp targeted agent 1

    CAS:
    <p>Lysosomal P-gp targeted agent 1 (Compound 14) is an antitumor drug that targets lysosomal P-glycoprotein (Pgp). It is selectively transported to lysosomes via overexpressed Pgp, releasing nitric oxide that generates reactive oxygen species (ROS), causing lysosomal membrane permeabilization (LMP) and inducing apoptosis. This compound can overcome resistance mediated by P-glycoprotein, leading to cell cycle arrest while maintaining relatively low toxicity to normal cells. It exhibits antitumor activity by significantly inhibiting tumor growth.</p>
    Fórmula:C39H34N2O9S
    Cor e Forma:Solid
    Peso molecular:706.76

    Ref: TM-T206140