CAS 30562-34-6

Geldanamicina

Descrição:

Geldanamicina é um antibiótico ansamicina benzoquinona que é conhecido principalmente por sua capacidade de inibir a proteína de choque térmico 90 (Hsp90), uma chaperona molecular envolvida na estabilização e função de numerosas proteínas cliente, incluindo muitas envolvidas na progressão do câncer. Sua estrutura química apresenta um núcleo bicíclico complexo com um moiety de quinona, contribuindo para sua atividade biológica. Geldanamicina exibe uma gama de efeitos farmacológicos, particularmente na terapia do câncer, pois pode induzir apoptose em células tumorais ao interromper a função de proteínas oncogênicas. Além disso, mostrou potencial em direcionar várias vias de sinalização, tornando-se um assunto de interesse no desenvolvimento de medicamentos. No entanto, seu uso clínico é limitado por problemas de toxicidade e solubilidade, levando ao desenvolvimento de análogos com propriedades aprimoradas. Como um produto natural derivado da bactéria *Streptomyces hygroscopicus*, Geldanamicina serve como uma ferramenta valiosa tanto em contextos de pesquisa quanto terapêuticos, particularmente no estudo da biologia do câncer e no desenvolvimento de inibidores de Hsp90.

Fórmula: C₂₉H₄₀N₂O₉

InChI: InChI=1/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

Chave InChI: InChIKey=QTQAWLPCGQOSGP-KSRBKZBZSA-N

SMILES: O(C)C1=C2C(=O)C(=CC1=O)NC(=O)\C(\C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(\C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2

Sinónimos:

• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• (8S,9S,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-
• 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
• Brn 1633093
• NSC 212518
• Nsc 122750
• U-29135
• [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione
• Geldanamycin
• [(4Z,6E,8R,9R,10Z,12R,13R,14R,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-9-yl] carbamate
• GELDANAMYCIN, STREPTOMYCES HYGROSCOPICUS
• GELDANAMYCIN, 99+%
• [(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate
• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21(1)-pentene-3,20,22-trione
• CP-122634
• nsc122750
• GA
• GELDANAMYCIN (GDM)
• 9,13-DIHYDROXY-8,14,19-TRIMETHOXY-4,10,12,16-TETRAMETHYL-2-AZABICYCLO[16.3.1]DOCOSA-4,6,10,18,21-PENTAENE-3,20,22-TRIONE, 9-CARBAMATE
• GELDANAMYCIN FROM STREPTOMYCES*HYGROSCOP ICUS
• [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• Streptomyces hygroscopicus

Geldanamycin

CAS: 30562-34-6

Fórmula: C₂₉H₄₀N₂O₉

Pureza: >95.0%(qNMR)

Cor e Forma: White to Yellow to Orange powder to crystal

Peso molecular: 560.64

Ref: 3B-G0334

Geldanamycin, 98+%

CAS: 30562-34-6

Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase

Fórmula: C₂₉H₄₀N₂O₉

Pureza: 98+%

Cor e Forma: Yellow, Powder or crystals or crystalline powder

Peso molecular: 560.64

Ref: 02-J63397

Geldanamycin

CAS: 30562-34-6

Fórmula: C₂₉H₄₀N₂O₉

Pureza: 100.0%

Cor e Forma: Orange amorphous solid

Peso molecular: 560.0

Ref: 8R-PB0001

[8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione

CAS: 30562-34-6

Fórmula: C₂₉H₄₀N₂O₉

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 560.6359

Ref: IN-DA0038U7

Geldanamycin

CAS: 30562-34-6

Geldanamycin

Pureza: ≥95%

Peso molecular: 560.64g/mol

Ref: 54-BUP06940

Geldanamycin

CAS: 30562-34-6

Fórmula: C₂₉H₄₀N₂O₉

Pureza: ≥ 98.0%

Cor e Forma: Yellow to orange powder

Peso molecular: 560.64

Ref: 7W-GA6838

Geldanamycin

CAS: 30562-34-6

Fórmula: C₂₉H₄₀N₂O₉

Peso molecular: 560.64

Ref: 4Z-G-165001

Geldanamycin, Streptomyces hygroscopicus

CAS: 30562-34-6

Fórmula: C₂₉H₄₀N₂O₉

Pureza: >95%

Cor e Forma: Solid

Peso molecular: 560.644

Ref: 10-M01803

Geldanamycin

CAS: 30562-34-6

Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.

Fórmula: C₂₉H₄₀N₂O₉

Pureza: 97.59% - 99.27%

Cor e Forma: Yellow To Orange Powder

Peso molecular: 560.64

Ref: TM-T6343

Geldanamycin

CAS: 30562-34-6

Geldanamycin

Fórmula: C₂₉H₄₀N₂O₉

Pureza: By hplc: 99.66% (Typical Value in Batch COA)

Cor e Forma: yellow powder

Peso molecular: 560.64g/mol

Ref: 54-BIG2461

Geldanamycin

Produto Controlado

CAS: 30562-34-6

Applications Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
References Supko, J.G., et al.: Cancer Chemother. Pharmacol., 36, 305 (1995), Chavany, C., et al.: J. Biol. Chem., 271, 4974 (1996), Schneider, C., et al.: Proc. Natl. Acad. Sci., 93, 14536 (1996), Whitesell, L., et al.: Mol. Endocrinol., 10, 705 (1996), Stebbins, C.E., et al.: Cell, 89, 239 (1997),

Fórmula: C₂₉H₄₀N₂O₉

Cor e Forma: Neat

Peso molecular: 560.64

Ref: TR-G304500

Geldanamycin (GLD) ex. Streptomyces Hygroscopicus, 98%

CAS: 30562-34-6

Fórmula: C₂₉H₄₀N₂O₉

Pureza: min. 98%

Cor e Forma: White to Yellow to Orange, Powder or Crystals, Clear

Peso molecular: 560.64

Ref: SR-23813

Geldanamycin-FITC

Produto Controlado

CAS: 30562-34-6

Fórmula: C₅₅H₆₃N₅O₁₃S

Cor e Forma: Neat

Peso molecular: 1034.18

Ref: TR-G368230

Geldanamycin

CAS: 30562-34-6

Inhibits chaperone protein HSP90; anti-proliferative; antineoplastic

Fórmula: C₂₉H₄₀N₂O₉

Pureza: Min. 95%

Cor e Forma: Yellow Powder

Peso molecular: 560.64 g/mol

Ref: 3D-AG23651