CAS 3068378-38-8

GSK3β-IN-2

CAS: 3068378-38-8

GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.

Fórmula: C₂₅H₁₈N₄O

Cor e Forma: Solid

Peso molecular: 390.437

Ref: TM-T205461