CAS 30868-30-5

Pirazofurina

Descrição:

Pirazofurina é um análogo de nucleosídeo sintético com notáveis propriedades antivirais, direcionando-se principalmente a vírus de RNA. É caracterizado por sua estrutura de anel de pirazol, que é essencial para sua atividade biológica. O composto exibe um mecanismo de ação que envolve a inibição da síntese de RNA viral, tornando-se um potencial agente terapêutico contra várias infecções virais. Pirazofurina é solúvel em água e apresenta estabilidade moderada em condições fisiológicas. Seu perfil farmacológico inclui eficácia antiviral, embora seu uso possa ser limitado por fatores como toxicidade e desenvolvimento de resistência em populações virais. Pesquisas indicaram que também pode possuir efeitos imunomoduladores, contribuindo para sua atividade antiviral geral. Assim como muitos análogos de nucleosídeos, a consideração cuidadosa da dosagem e administração é crucial para maximizar os benefícios terapêuticos enquanto minimiza os efeitos adversos. Estudos em andamento continuam a explorar suas potenciais aplicações no tratamento de doenças virais, particularmente no contexto de ameaças virais emergentes.

Fórmula: C₉H₁₃N₃O₆

InChI: InChI=1/C9H13N3O6/c10-9(17)4-6(15)3(11-12-4)8-7(16)5(14)2(1-13)18-8/h2,5,7-8,13-16H,1H2,(H2,10,17)(H,11,12)/t2-,5-,7-,8+/m1/s1

Chave InChI: InChIKey=XESARGFCSKSFID-FLLFQEBCSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(O)=C(C(N)=O)NN2

Sinónimos:

• (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-D-ribitol
• (1S)-1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• (1S)-1-{(5Z)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• 1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydropentitol
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-beta-D-ribofuranosyl-
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 4-Hydroxy-3-beta-<span class="text-smallcaps">D</span>-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-pyrazole-5-carboxamide
• Antibiotic A 23813
• NSC 143095
• Pirazofurin
• Przf
• Pyrazole-3-carboxamide, 4-hydroxy-5-beta-L-ribofuranosyl-
• Pyrazomycin
• Pyrozofurin
• beta-Pyrazomycin
• β-Pyrazofurin
• β-Pyrazomycin
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-D-ribofuranosyl-
• Pyrazofurin
• 4-Hydroxy-3-β-D-ribofuranosyl-1H-pyrazole-5-carboxamide
• 3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide
• compound47599
• nsc143095
• 47599
• 4-HYDROXY-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide
• A-23813
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid
• PYRAZOFURIN MONOHYDRATE

4-HYDROXY-3-β-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE

CAS: 30868-30-5

Fórmula: C₉H₁₃N₃O₆

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 259.2160

Ref: IN-DA00BE0N

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

CAS: 30868-30-5

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

Pureza: 97%

Peso molecular: 259.22g/mol

Ref: 54-OR1074824

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin is an antiviral drug that inhibits viral DNA synthesis by inhibiting the enzyme ribonucleotide reductase. It has been shown to be effective for bowel disease in mice and murine hepatoma cells. Pyrazofurin binds to the pyrazole ring of the enzyme, thereby inhibiting its activity and preventing the formation of uridine triphosphate (UTP) from uridine monophosphate (UMP). This compound also has anti-cancer activities, which may be due to its ability to inhibit cell growth by targeting enzymes that are expressed at high levels in cancer tissues. Pyrazofurin is used as a biological sample to measure enzyme activities such as dextran sulfate and other substances that can be detected through colorimetric or fluorometric assays.

Fórmula: C₁₁H₁₄F₃N₃O₈

Pureza: Min. 95%

Peso molecular: 373.24 g/mol

Ref: 3D-FBA86830

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).

Fórmula: C₉H₁₃N₃O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 259.22

Ref: TM-T16690