CAS 315-22-0
:Monocrotalina
Descrição:
Monocrotalina é um alcaloide que ocorre naturalmente, derivado principalmente da espécie vegetal *Crotalaria* e é conhecido por suas propriedades tóxicas. Pertence à classe dos alcaloides pirrolizidínicos, que são caracterizados por uma estrutura bicíclica contendo um anel de pirrolizidina. Monocrotalina exibe hepatotoxicidade e pode causar hipertensão pulmonar, tornando-se um assunto de interesse em toxicologia e farmacologia. Sabe-se que o composto passa por ativação metabólica no fígado, levando à formação de metabólitos reativos que podem danificar estruturas celulares, particularmente no fígado e nos pulmões. Seu mecanismo de ação envolve a formação de adutos de DNA, que podem resultar em efeitos mutagênicos. Devido à sua natureza tóxica, Monocrotalina é frequentemente estudado no contexto da saúde e segurança ambiental, especialmente em relação aos riscos de exposição associados a certas plantas. Além disso, tem sido utilizado em pesquisas para modelar a hipertensão pulmonar em estudos com animais, fornecendo insights sobre os mecanismos da doença e possíveis abordagens terapêuticas.
Fórmula:C16H23NO6
InChI:InChI=1/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/p+1/t9-,11+,12+,15+,16-/m0/s1
Chave InChI:InChIKey=QVCMHGGNRFRMAD-XFGHUUIASA-N
SMILES:O=C1O[C@]2([C@@]3(N(CC2)CC=C3COC(=O)[C@](C)(O)[C@](C)(O)[C@H]1C)[H])[H]
Sinónimos:- (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione
- (2,3,4-gh)pyrrolizine-2,6(3H)-dione, (4,5,8,10,12,13,13a,13b)-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino-
- (3R,4R,5R,13aR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3R,4R,5R,13aR,13bR)-4,5,8,10,12,13,13a,13b-Octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
- (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3R,4R,5R,13aR,13bS)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
- (3R,4S,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3S,4S,5S,13aS,13bS)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- 12-beta,13-beta-Dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine
- 14,19-Dihydro-12,13-dihydroxy(13-alpha,14-alpha)-20-norcrotalanan-11,15-dione
- 14,19-Dihydro-12,13-dihydroxy-20-norcrotolanan-11,15-dione
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)-
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)- (9CI)
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13α,14α)-
- 2H-(1,6)Dioxacycloundecino(2,3,4-gh)pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-
- 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine, 20-norcrotalanan-11,15-dione deriv.
- 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, [3R-(3R*,4R*,5R*,13aR*,13bR*)]-
- A 6080
- Brn 0048732
- Ccris 416
- Crotaline
- Hsdb 3513
- Monocrotalin
- Nci-C56462
- Nsc 28693
- Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate
- Monocrotaline
- 4-27-00-06660 (Beilstein Handbook Reference)
- 4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- MONOCROTOLLINE (99%)
- Bulbus Lilii
- Monocrotoline
- CROTALIN
- (13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio
- Monocrotaline/crotaline
- Monocrotaline, >=98%
- MONOCRATALINE
- Monccrotalire
- (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,1
- Monocrotalinum
- 14,19-Dihydro-12,13-dihydroxy(13alpha,14alpha)-20-norcrotalanan-11,15-dione
- MONOCROTALIN(CROTALIN)(RG)
- 5-trimethyl-2h-(1,6)dioxacycloundecino-droxy-4
- 20-norcrotalanan-11,15-dione,14,19-dihydro-12,13-dihydroxy-,(13-alpha,14-al
- (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy
- Crotaline,Monocrotaline
- Monocrotaline,99%
- (13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione
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15 produtos.
Monocrotalin
CAS:Monocrotalin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.Fórmula:C16H23NO6Pureza:(HPLC) ≥90%Cor e Forma:PowderPeso molecular:325.37(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-Dione
CAS:(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-DionePureza:98%Peso molecular:325.36g/molCrotaline
CAS:Fórmula:C16H23NO6Pureza:≥ 98.0%Cor e Forma:White to off-white crystalline powderPeso molecular:325.36Monocrotaline
CAS:Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and has certain cellular activity against HepG2 cells.Cost-effective and quality-assured.
Fórmula:C16H23NO6Pureza:98% - 99.94%Cor e Forma:White To Light Tan PowderPeso molecular:325.36Monocrotaline
CAS:Natural alkaloidFórmula:C16H23NO6Pureza:≥ 95.0 % (HPLC)Cor e Forma:PowderPeso molecular:325.36Monocrotaline
CAS:Applications A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),Fórmula:C16H23NO6Cor e Forma:White To Off-WhitePeso molecular:325.36Monocrotaline
CAS:Toxin; induces pulmonary hypertensionFórmula:C16H23NO6Pureza:Min. 98%Cor e Forma:White Off-White Clear LiquidPeso molecular:325.36 g/molMonocrotaline-d4
CAS:Produto ControladoApplications Monocrotaline-d4 is labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),Fórmula:C16D4H19NO6Cor e Forma:NeatPeso molecular:329.382
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