CAS 315-22-0

Monocrotalina

Descrição:

Monocrotalina é um alcaloide que ocorre naturalmente, derivado principalmente da espécie vegetal *Crotalaria* e é conhecido por suas propriedades tóxicas. Pertence à classe dos alcaloides pirrolizidínicos, que são caracterizados por uma estrutura bicíclica contendo um anel de pirrolizidina. Monocrotalina exibe hepatotoxicidade e pode causar hipertensão pulmonar, tornando-se um assunto de interesse em toxicologia e farmacologia. Sabe-se que o composto passa por ativação metabólica no fígado, levando à formação de metabólitos reativos que podem danificar estruturas celulares, particularmente no fígado e nos pulmões. Seu mecanismo de ação envolve a formação de adutos de DNA, que podem resultar em efeitos mutagênicos. Devido à sua natureza tóxica, Monocrotalina é frequentemente estudado no contexto da saúde e segurança ambiental, especialmente em relação aos riscos de exposição associados a certas plantas. Além disso, tem sido utilizado em pesquisas para modelar a hipertensão pulmonar em estudos com animais, fornecendo insights sobre os mecanismos da doença e possíveis abordagens terapêuticas.

Fórmula: C₁₆H₂₃NO₆

InChI: InChI=1/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/p+1/t9-,11+,12+,15+,16-/m0/s1

Chave InChI: InChIKey=QVCMHGGNRFRMAD-XFGHUUIASA-N

SMILES: O=C1O[C@]2([C@@]3(N(CC2)CC=C3COC(=O)[C@](C)(O)[C@](C)(O)[C@H]1C)[H])[H]

Sinónimos:

• (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione
• (2,3,4-gh)pyrrolizine-2,6(3H)-dione, (4,5,8,10,12,13,13a,13b)-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino-
• (3R,4R,5R,13aR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3R,4R,5R,13aR,13bR)-4,5,8,10,12,13,13a,13b-Octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
• (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3R,4R,5R,13aR,13bS)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
• (3R,4S,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3S,4S,5S,13aS,13bS)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• 12-beta,13-beta-Dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine
• 14,19-Dihydro-12,13-dihydroxy(13-alpha,14-alpha)-20-norcrotalanan-11,15-dione
• 14,19-Dihydro-12,13-dihydroxy-20-norcrotolanan-11,15-dione
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)-
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)- (9CI)
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13α,14α)-
• 2H-(1,6)Dioxacycloundecino(2,3,4-gh)pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-
• 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine, 20-norcrotalanan-11,15-dione deriv.
• 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, [3R-(3R*,4R*,5R*,13aR*,13bR*)]-
• A 6080
• Brn 0048732
• Ccris 416
• Crotaline
• Hsdb 3513
• Monocrotalin
• Nci-C56462
• Nsc 28693
• Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate
• Monocrotaline
• 4-27-00-06660 (Beilstein Handbook Reference)
• 4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• MONOCROTOLLINE (99%)
• Bulbus Lilii
• Monocrotoline
• CROTALIN
• (13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio
• Monocrotaline/crotaline
• Monocrotaline, >=98%
• MONOCRATALINE
• Monccrotalire
• (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,1
• Monocrotalinum
• 14,19-Dihydro-12,13-dihydroxy(13alpha,14alpha)-20-norcrotalanan-11,15-dione
• MONOCROTALIN(CROTALIN)(RG)
• 5-trimethyl-2h-(1,6)dioxacycloundecino-droxy-4
• 20-norcrotalanan-11,15-dione,14,19-dihydro-12,13-dihydroxy-,(13-alpha,14-al
• (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy
• Crotaline,Monocrotaline
• Monocrotaline,99%
• (13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione

Monocrotalin

CAS: 315-22-0

Monocrotalin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₁₆H₂₃NO₆

Pureza: (HPLC) ≥90%

Cor e Forma: Powder

Peso molecular: 325.37

Ref: 11-7351

Monocrotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 325.3569

Ref: IN-DA00BYAV

(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-Dione

CAS: 315-22-0

(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-Dione

Pureza: 98%

Peso molecular: 325.36g/mol

Ref: 54-OR1026386

Monocrotaline (Crotaline)

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Peso molecular: 325.36

Ref: 4Z-M-167001

Monocrotaline

CAS: 315-22-0

Monocrotaline

Pureza: ≥95%

Peso molecular: 325.36g/mol

Ref: 54-BUP15752

Crotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: ≥ 98.0%

Cor e Forma: White to off-white crystalline powder

Peso molecular: 325.36

Ref: 7W-GX1396

Monocrotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: 99%

Peso molecular: 325.361

Ref: BP-BP0957

Monocrotaline

Produto Controlado

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Cor e Forma: Neat

Peso molecular: 325.36

Ref: 04-C15298000

Monocrotaline-d3

CAS: 315-22-0

Fórmula: C₁₆H₂₀D₃NO₆

Peso molecular: 328.38

Ref: 4Z-M-167003

Monocrotaline

CAS: 315-22-0

Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and has certain cellular activity against HepG2 cells.Cost-effective and quality-assured.

Fórmula: C₁₆H₂₃NO₆

Pureza: 98% - 99.94%

Cor e Forma: White To Light Tan Powder

Peso molecular: 325.36

Ref: TM-T2803

Monocrotaline

CAS: 315-22-0

Natural alkaloid

Fórmula: C₁₆H₂₃NO₆

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 325.36

Ref: 5G-89251

Monocrotaline

CAS: 315-22-0

Applications A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),

Fórmula: C₁₆H₂₃NO₆

Cor e Forma: White To Off-White

Peso molecular: 325.36

Ref: TR-M526000

Monocrotaline

CAS: 315-22-0

Toxin; induces pulmonary hypertension

Fórmula: C₁₆H₂₃NO₆

Pureza: Min. 98%

Cor e Forma: White Off-White Clear Liquid

Peso molecular: 325.36 g/mol

Ref: 3D-FM64904

Monocrotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 325.361

Ref: 10-F002602

Monocrotaline-d4

Produto Controlado

CAS: 315-22-0

Applications Monocrotaline-d4 is labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),

Fórmula: C₁₆D₄H₁₉NO₆

Cor e Forma: Neat

Peso molecular: 329.382

Ref: TR-M526002