CAS 317318-70-0

GW 501516

Descrição:

GW 501516, também conhecido como Cardarine, é um composto sintético que pertence à classe de medicamentos conhecidos como moduladores seletivos do receptor androgênico (SARMs). Foi inicialmente desenvolvido para o tratamento de doenças metabólicas e cardiovasculares. GW 501516 funciona como um potente agonista do receptor delta ativado por proliferadores de peroxissomos (PPARδ), que desempenha um papel crucial na regulação do metabolismo de ácidos graxos e na homeostase energética. Este composto é conhecido por seu potencial para aumentar a resistência e promover a perda de gordura, tornando-se popular entre atletas e fisiculturistas, apesar de seu status controverso nos esportes devido a preocupações sobre a melhoria de desempenho. GW 501516 foi estudado por seus efeitos nos perfis lipídicos, na sensibilidade à insulina e na saúde metabólica geral. No entanto, sua segurança e eficácia a longo prazo em humanos continuam sob investigação, e não é aprovado para uso médico por agências reguladoras. Assim como qualquer substância, o uso de GW 501516 envolve riscos e efeitos colaterais potenciais, exigindo cautela e pesquisa aprofundada antes do uso.

Fórmula: C₂₁H₁₈F₃NO₃S₂

InChI: InChI=1/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)

Chave InChI: InChIKey=YDBLKRPLXZNVNB-UHFFFAOYSA-N

SMILES: C(SC1=CC(C)=C(OCC(O)=O)C=C1)C=2SC(=NC2C)C3=CC=C(C(F)(F)F)C=C3

Sinónimos:

• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid
• 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
• 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]thiazol-5-yl]methyl]thio]phenoxy]acetic acid
• Acetic acid, (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-
• Acetic acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-
• Gw 1516
• Gw 501516
• Gw501516
• [2-Methyl-4-[([4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl)thio]phenoxy]acetic acid
• {2-Methyl-4-[({4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazol-5-Yl}Methyl)Sulfanyl]Phenoxy}Acetic Acid
• GW501516, Free Acid
• ENDUROBOL
• {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid
• Cardarine(GW501516, GSK-516)
• {2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid
• 2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic acid
• CARDARINE
• GW501516(GSK-516)
• Aceticacid, [2-Methyl-4-[[[4-Methyl-2-[4-(trifluoroMethyl)phenyl]-5-thiazolyl]Methyl]thio]phenoxy]-(9CI)
• 2-(4-((2-(4-(TRIFLUOROMETHYL)PHENYL)-5-METHYLTHIAZOL-4-YL)METHYLTHIO)-2-METHYLPHENOXY)ACETIC ACID
• 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
• GW 501516, >=98%
• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic
• GW501516/GW1516/GW-1516/GW501516
• GSK-516
• Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid
• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a
• GW 1516 ,GSK-516
• GW-501615

Cardarine

CAS: 317318-70-0

Cor e Forma: Neat

Ref: 04-C11041800

GW 501516

CAS: 317318-70-0

Fórmula: C₂₁H₁₈F₃NO₃S₂

Peso molecular: 453.49

Ref: 4Z-G-237004

GW 501516

CAS: 317318-70-0

GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: 98.91% - 99.64%

Cor e Forma: White Solid

Peso molecular: 453.50

Ref: TM-T6151

GW501516

CAS: 317318-70-0

Ref: 7W-GW9340

GW 501516 - Bio-X ™

Produto Controlado

CAS: 317318-70-0

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 453.5 g/mol

Ref: 3D-BG300099

GW 501516

Produto Controlado

CAS: 317318-70-0

Agonist of peroxisome proliferator-activated receptor δ/β (PPARδ/β). The compound activates the nuclear receptor PPARδ downstream signalling and affects hepatic AMPK levels. It boosts the activity of the lipin 1-PPARα-PPARγ coactivator 1 (PGC-1)-α pathway and increases hepatic fatty acid oxidation. It was reported that GW 501516 prevents high-fat diet induced hypertriglyceridemia.

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 453.50 g/mol

Ref: 3D-FM23721

GW 501516

Produto Controlado

CAS: 317318-70-0

Stability No Data available
Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.
References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017

Fórmula: C₂₁H₁₈F₃NO₃S₂

Cor e Forma: Neat

Peso molecular: 453.50

Ref: TR-G931500

GW 501516

CAS: 317318-70-0

Fórmula: C₂₁H₁₈F₃NO₃S₂

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 453.4977

Ref: IN-DA007ION