CAS 32385-11-8

Sisomicina

Descrição:

Sisomicina é um antibiótico aminoglicosídeo que é usado principalmente para tratar infecções causadas por bactérias Gram-negativas. É derivado da fermentação da bactéria Micromonospora purpurea. Sisomicina exibe um amplo espectro de atividade antibacteriana, sendo particularmente eficaz contra várias cepas de Pseudomonas e espécies de Enterobacter. O mecanismo de ação envolve a ligação à subunidade ribossômica 30S, levando à inibição da síntese de proteínas, o que resulta na morte celular bacteriana. Sisomicina é tipicamente administrado por injeção devido à sua baixa biodisponibilidade oral. Sua farmacocinética inclui excreção renal, necessitando ajustes de dosagem em pacientes com função renal comprometida. Embora geralmente bem tolerado, os efeitos colaterais potenciais podem incluir nefrotoxicidade e ototoxicidade, preocupações comuns associadas aos aminoglicosídeos. A estrutura química de Sisomicina apresenta múltiplos grupos amino, contribuindo para sua solubilidade e interação com ribossomos bacterianos. Assim como com todos os antibióticos, testes de suscetibilidade adequados são recomendados para garantir a eficácia contra patógenos específicos.

Fórmula: C₁₉H₃₇N₅O₇·H₂O₄S

InChI: InChI=1/C19H37N5O7.H2O4S/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h3,9-18,24-27H,4-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10+,11-,12+,13?,14-,15+,16-,17-,18-,19+;/m1./s1

Chave InChI: InChIKey=URWAJWIAIPFPJE-YFMIWBNJSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3

Sinónimos:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-
• Antibiotic 66-40
• Antibiotic 6640
• BactoCeaze
• Ensamycin
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-<span class="text-smallcaps">L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</smallcap>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Rickamicin
• Sch 13475
• Siseptin
• Sisomicin
• Sisomicina
• Sisomicine
• Dehydrogentamicin Cla
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl (2xi)-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-erythro-pentopyranoside sulfate (salt)
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
• Sisomicin base
• 4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)pentopyranoside
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-D-streptamine
• 6-O-(4-C-Methyl-3-methylamino-3-deoxy-β-L-arabinopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-4-hexenopyranosyl)-2-deoxy-D-streptamine
• O-3-Deoxy-4-C-methyl-3-(methylamino)--L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy- D-Streptamine
• Sisomicin (C1a oxidation peak)
• Sisomicin base (intermediates)
• SISOMYCIN
• O-3-deoxy-4C-methyl-3-(methylamino)--L-arabinopiranozyl-(1-6)-O[2,6-diamino-2,3,4,6-tetradeooxy-a-D-glycerohexy-4-enopiranozyl-(1-4)]-2-deoxy-D-streptamycin

Sisomicin

CAS: 32385-11-8

Fórmula: C₁₉H₃₇N₅O₇

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 447.5264

Ref: IN-DA00C0C4

Sisomicin

CAS: 32385-11-8

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.

Fórmula: C₁₉H₃₇N₅O₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 447.53

Ref: TM-T20675

Sisomicin (Netilmicin EP Impurity A)

CAS: 32385-11-8

Fórmula: C₁₉H₃₇N₅O₇

Cor e Forma: White To Off-White Solid

Peso molecular: 447.53

Ref: 4Z-S-080002

Sisomicin

CAS: 32385-11-8

Peso molecular: 447.53

Ref: 7W-GA4392

Sisomicin

Produto Controlado

CAS: 32385-11-8

Applications Sisomicin is an Antibacterial. Gentamicin-like aminoglycoside antibiotic; has broad spectrum antibiotic activity.
References Weinstein, M.J., et al.: J. Antibiot., 23, 551 (1970), Sculier, J.P., et al.: J. Antimicrob. Chemother., 9, 63 (1982), Noone, P., et al.: Drugs, 27, 548 (1984),

Fórmula: C₁₉H₃₇N₅O₇

Cor e Forma: Neat

Peso molecular: 447.53

Ref: TR-S488500

Sisomicin

CAS: 32385-11-8

Sisomicin is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating severe bacterial infections resistant to other aminoglycosides.

Fórmula: C₁₉H₃₇N₅O₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 447.53 g/mol

Ref: 3D-AS27839

Netilmicin EP Impurity A

CAS: 32385-11-8

Fórmula: C₁₉H₃₇N₅O₇

Peso molecular: 447.53

Ref: ST-EA-CP-N94001

Sisomicin Sulfate

CAS: 32385-11-8, 53179-09-2

Fórmula: C₁₉H₃₇N₅O₇H₂SO₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 692.71

Ref: 3B-I1049