CAS 32887-01-7

Meciliname

Descrição:

Meciliname é um antibiótico beta-lactâmico que pertence à classe das penicilinas, projetado especificamente para atacar e inibir a síntese da parede celular bacteriana. É particularmente eficaz contra certas bactérias Gram-negativas, incluindo cepas de Escherichia coli e Proteus mirabilis. Meciliname funciona ligando-se a proteínas de ligação à penicilina (PBPs), que são essenciais para a ligação cruzada das camadas de peptidoglicano nas paredes celulares bacterianas, levando, em última instância, à lise celular e morte. Este antibiótico é caracterizado por sua toxicidade relativamente baixa para as células humanas, tornando-o uma opção adequada para tratar infecções do trato urinário e outras infecções bacterianas. Meciliname é frequentemente administrado por via oral e é conhecido por sua estabilidade na presença de certas beta-lactamases, embora possa ser suscetível a outras. Suas propriedades farmacocinéticas incluem boa absorção e distribuição no corpo, com excreção renal sendo uma rota primária de eliminação. No geral, Meciliname representa um valioso agente terapêutico no arsenal contra infecções bacterianas, particularmente aquelas causadas por cepas resistentes.

Fórmula: C₁₅H₂₃N₃O₃S

InChI: InChI=1S/C15H23N3O3S/c1-15(2)11(14(20)21)18-12(19)10(13(18)22-15)16-9-17-7-5-3-4-6-8-17/h9-11,13H,3-8H2,1-2H3,(H,20,21)/t10-,11+,13-/m1/s1

Chave InChI: InChIKey=BWWVAEOLVKTZFQ-NTZNESFSSA-N

SMILES: C(O)(=O)[C@@H]1N2[C@@]([C@H](N=CN3CCCCCC3)C2=O)(SC1(C)C)[H]

Sinónimos:

• (2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-{[(E)-azepan-1-ylmethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (+)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
• 6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]penicillanic acid
• 6-[β-(Hexahydro-1H-azepin-1-yl)methylenamino]penicillanic acid
• 6β-[(Hexahydro-1H-azepin-1-yl)methyleneamino]penicillanic acid
• Amdinocillin
• Coactin
• Fl 1060
• Hexacillin
• Hexapen
• Mecilinamo
• Penicillin Hx
• [(2,2-dimethylpropanoyl)oxy]methyl (5R,6R)-6-{[(E)-azepan-1-ylmethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Mecillinam, 90+%

CAS: 32887-01-7

Effective against gram negative bacteria

Fórmula: C₁₅H₂₃N₃O₃S

Pureza: 90+%

Cor e Forma: Powder, White to off-white

Peso molecular: 325.43

Ref: 02-J66774

(2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

CAS: 32887-01-7

Fórmula: C₁₅H₂₃N₃O₃S

Cor e Forma: Solid

Peso molecular: 325.4264

Ref: IN-DA00JKJ5

Mecillinam

CAS: 32887-01-7

Mecillinam

Pureza: ≥95%

Peso molecular: 325.43g/mol

Ref: 54-BUP11179

Mecillinam

CAS: 32887-01-7

Fórmula: C₁₅H₂₃N₃O₃S

Pureza: ≥ 95%

Cor e Forma: White crystalline powder

Peso molecular: 325.43

Ref: 7W-GA6807

Mecillinam-d12

CAS: 32887-01-7

Fórmula: C₁₅H₁₁D₁₂N₃O₃S

Cor e Forma: Pale Yellow Solid

Peso molecular: 337.50

Ref: 4Z-M-156002

Mecillinam

CAS: 32887-01-7

Fórmula: C₁₅H₂₃N₃O₃S

Peso molecular: 325.43

Ref: 4Z-M-156001

Mecillinam

CAS: 32887-01-7

Mecillinam, an antibiotic, targets Gram-negative bacteria, mainly for urinary infections and some fevers.

Fórmula: C₁₅H₂₃N₃O₃S

Pureza: 95.53% - ≥95%

Cor e Forma: Solid

Peso molecular: 325.43

Ref: TM-T21369

Amdinocillin (>85%)

Produto Controlado

CAS: 32887-01-7

Fórmula: C₁₅H₂₃N₃O₃S

Pureza: ~85%

Cor e Forma: Neat

Peso molecular: 325.43

Ref: TR-A576405

Amdinocillin

CAS: 32887-01-7

Amdinocillin is a semisynthetic antibiotic with broad-spectrum activity that is part of the aminopenicillin family. It is used in the treatment of bacterial infections such as those caused by Gram-negative bacteria, and to treat methicillin-resistant Staphylococcus (MRSA). The clinical isolate Amdinocillin has an inhibitory concentration (IC) of 0.25 μg/mL against Enterobacter aerogenes and Enterobacter cloacae, and it displays a synergistic effect in combination with other antibiotics. The mechanism of action is that prevents bacterial growth and proliferation by inhibiting cell wall synthesis and causing lysis, which allows for drug therapy against specific types of bacteria.

Fórmula: C₁₅H₂₃N₃O₃S

Pureza: (%) Min. 97%

Cor e Forma: White Slightly Yellow Powder

Peso molecular: 325.43 g/mol

Ref: 3D-AA17347

Mecillinam (MCL) extrapure, 95%

CAS: 32887-01-7

Fórmula: C₁₅H₂₃N₃O₃S

Pureza: min. 95.0%

Cor e Forma: White to Light yellow to Light beige, Powder

Peso molecular: 325.43

Ref: SR-54474

Amdinocillin

Produto Controlado

CAS: 32887-01-7

Applications Active antibacterial against gram-negative bacteria.
References Cagnacci, S., et al.: J. Clin. Microbiol., 46, 2605 (2008), Obach, R., et al.: Drug Metab. Disposition, 36, 1385 (2008), Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008),

Fórmula: C₁₅H₂₃N₃O₃S

Cor e Forma: White

Peso molecular: 325.43

Ref: TR-A576300

Mecillinam, Antibiotic for Culture Media Use Only

CAS: 32887-01-7

Mecillinam is a beta-lactam antibiotic specifically designed for use in culture media. It is derived from the amidinopenicillin family, featuring a unique ability to interfere with bacterial cell wall synthesis. Its mode of action involves inhibiting penicillin-binding protein 2 (PBP2), an essential enzyme for cell wall elongation and maintenance in Gram-negative bacteria. This targeted inhibition results in the formation of spherical cells and subsequent cell lysis.

Fórmula: C₁₅H₂₃N₃O₃S

Pureza: Min. 95 Area-%

Peso molecular: 325.43 g/mol

Ref: 3D-Q-201343