CAS 32986-56-4
:Tobramicina
Descrição:
Tobramicina é um antibiótico aminoglicosídeo usado principalmente para tratar infecções causadas por bactérias Gram-negativas, particularmente Pseudomonas aeruginosa. É eficaz contra uma variedade de infecções bacterianas, especialmente em pacientes com fibrose cística ou aqueles com sistemas imunológicos comprometidos. A substância é caracterizada por sua capacidade de inibir a síntese de proteínas bacterianas ligando-se à subunidade ribossômica 30S, levando à leitura incorreta do mRNA e, em última instância, à morte celular. Tobramicina é tipicamente administrado por inalação, injeção ou aplicação tópica, dependendo da localização e gravidade da infecção. É conhecido por sua toxicidade relativamente baixa em comparação com outros aminoglicosídeos, embora ainda possa causar nefrotoxicidade e ototoxicidade, exigindo monitoramento cuidadoso da função renal e da audição durante o tratamento. A estrutura química de Tobramicina inclui múltiplos grupos hidroxila e amino, contribuindo para sua solubilidade e atividade biológica. Assim como todos os antibióticos, o surgimento de resistência é uma preocupação, tornando o uso apropriado e a adesão aos regimes prescritos essenciais para manter sua eficácia.
Fórmula:C18H37N5O9
InChI:InChI=1/C20H41N5O7/c21-5-8-1-7(10(22)4-13(8)27)2-9-11(23)3-12(24)19(16(9)28)32-20-18(30)15(25)17(29)14(6-26)31-20/h7-20,26-30H,1-6,21-25H2
Chave InChI:InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N
SMILES:O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)C[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
Sinónimos:- (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
- 3'-Deoxykanamycin B
- 4-Amino-2-[4,6-Diamino-3-[[2-Amino-5-(Aminomethyl)-4-Hydroxy-Cyclohexyl]Methyl]-2-Hydroxy-Cyclohexoxy]-6-(Hydroxymethyl)Tetrahydropyran-3,5-Diol
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</span>-ribo-hexopyranosyl-(1→4)]-2-deoxy-
- D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino- 2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-
- Deoxykanamycin B
- Nebramycin 6
- Nebramycin VI
- Nebramycin factor 6
- Nf 6
- Nsc 180514
- O-3-Amino-3-deoxy-α-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
- O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxystreptamine
- O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
- Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxy-, D-
- Tobi Podhaler
- Tobracin
- Tobradistin
- Tobralex
- Tobramax
- Tobramaxin
- Tobramicin
- Tobramicina
- Tobramycetin
- Tobramycin Base
- Tobramycin, Free Base
- Tobramycine
- Tobrex
- Tobrin
- Vantobra
- Tobramycin
- o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-[2,6-diamino-2,3,6-trideoxy-a
- TOBRAMYCIN (RE-EXPORT OF REJECTED MATERIAL RETURN TO VENDOR)
- TobramycinSulphate49842-07-1/Base
- 3’-deoxykanamycinb
- Tobramycin, Antibiotic for Culture Media Use Only
- Tobramycin,O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
- O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-
- Streptamine, O-3-amino-3-deoxy-a-D-glucopyranosyl-(14)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(16)]-2-deoxy-, D- (8CI)
- o-[3-amino-3-deoxy-α-d-glucopyranosyl-(1→6)]-o-[2,6-diamino-2,3,6-trideoxy-α-d-ribohexopyranosyl-(1→4)]-2-deoxy-d-streptamine
- (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxy-oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
- 1-epitobramycin
- O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
- streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(2,6-diamino-2,3,
- Tobramycin (base and/or unspecified salts)
- obracin
- gernebcin
- 4-[2,6-diamino-2,3,6-trideoxy-alpha-d-glycopyranosyl]-6-[3-amino-3-deoxy-alpha
- nebcin
- nebramycin6
- d-6-trideoxy-alpha-d-ribohexopyranosyl-(1-6))-2-deoxy
- >D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1?6)-O-2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1?4)-2-deoxy-
- O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1[R]6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1[R]4)]-2-deoxy-D-streptamine
- distobram
- -d-glycopyranosyl]-2-deoxystreptamine
- O-[3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL-(1->6)]-O-[2,6-DIAMINO-2,3,6-TRIDEOXY-ALPHA-D-RIBOHEXOPYRANOSYL-(1->4)]-2-DEOXY-D-STREPTAMINE
- O-3-Amino-3-deoxy-a-D-glucopyranosyl-(14)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(16)]-2-deoxystreptamine
- 6-trideoxy-alpha-d-ribo-hexopyranosyl-(1-4))-2-deoxy-
- tobra
- TobraMycin Base API
- nebramycinvi
- lpha-d-ribohexopyranosyl-(1-4)]-2-deoxy-d-streptamine
- d-6-tyrideoxy-alpha-d-ribohexopyranosyl-(1-6))-2-deoxy
- obramycin
- D-Streptamine, O-3-amino-3-deoxy-a-D-glucopyranosyl-(16)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(14)]-2-deoxy- (9CI)
- O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
- deoxykanamycinb
- nebramycinfactor6
- nebicina
- nf6
- Tobramycin (350 mg)
- O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
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Tobramycin
CAS:Fórmula:C18H37N5O9Pureza:>94.0%(T)Cor e Forma:White to Orange to Green powder to crystalPeso molecular:467.52Tobramycin, 900μg/mg
CAS:<p>Tobramycin, 900g/mg</p>Fórmula:C18H37N5O9Cor e Forma:White to pale cream, PowderPeso molecular:467.52SECOND INTERNATIONAL STANDARD FOR TOBRAMYCIN
CAS:SECOND INTERNATIONAL STANDARD FOR TOBRAMYCINFórmula:C18H37N5O9Peso molecular:467.5145TOBRAMYCIN FOR IDENTIFICATION CRS
CAS:TOBRAMYCIN FOR IDENTIFICATION CRSFórmula:C18H37N5O9Cor e Forma:White. Powder.Peso molecular:467.5145Tobramycin
CAS:Aminoglycoside antibioticsFórmula:C18H37N5O9Cor e Forma:White Off-White PowderPeso molecular:467.25913Tobramycin
CAS:Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.Fórmula:C18H37N5O9Pureza:99.21% - 99.87%Cor e Forma:White SolidPeso molecular:467.51Ref: IN-DA00I6BT
1g26,00€5g69,00€10g105,00€15g123,00€25g163,00€50g240,00€75g354,00€100g539,00€500gA consultar100mg30,00€200mg30,00€Tobramycin
CAS:<p>Tobramycin</p>Fórmula:C18H37N5O9Pureza:>97% by area (tlc) (Typical Value in Batch COA)Cor e Forma: white powderPeso molecular:467.51448g/molTobramycin, EP grade
CAS:Fórmula:C18H37N5O9Pureza:≤ 0.5%Cor e Forma:White to off-white powderPeso molecular:467.5Tobramycin
CAS:Fórmula:C18H37N5O9Pureza:≥ 900μg/mg (anhydrous basis)Cor e Forma:White or almost white powderPeso molecular:467.5Tobramycin
CAS:Produto Controlado<p>Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.<br>References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),<br></p>Fórmula:C18H37N5O9Cor e Forma:White To Off-WhitePeso molecular:467.51Tobramycin-D, 18O Acetic Acid Salt
CAS:Produto ControladoFórmula:C18H36DN5O8O·(xCH3COOH)Cor e Forma:Off White SolidPeso molecular:470.52 +(x60.05)Tobramycin Sulphate Salt
CAS:Fórmula:C18H37N5O9•x(H2O4S)Cor e Forma:NeatPeso molecular:467.51+x(98.08)Tobramycin Deuterated
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9.<br>References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),<br></p>Fórmula:C18H37N5O9forundeuteratedCor e Forma:Dark YellowPeso molecular:467.51Tobramycin
CAS:<p>Tobramycin used to treat severe infections with gram-negative bacteria and it is often applied in combination with beta-lactams. It has similar antimicrobial effects to gentamicin and is effective against all Enterobacteriacae, but more effective than gentamicin against P. aeruginosa, which is why it is often used for gentamicin-resistant strains, especially in the case of cystic fibrosis.</p>Fórmula:C18H37N5O9Pureza:Min. 97 Area-%Cor e Forma:White PowderPeso molecular:467.51 g/molTobramycin - high purity
CAS:<p>Inhibitor of protein synthesis; aminoglycoside</p>Fórmula:C18H37N5O9Pureza:Min. 900 Ug/MgCor e Forma:PowderPeso molecular:467.51 g/mol
