CAS 33069-62-4

Paclitaxel

Descrição:

Paclitaxel, com o número CAS 33069-62-4, é um produto natural complexo e um agente quimioterápico utilizado principalmente no tratamento de vários tipos de câncer, incluindo câncer de ovário, mama e pulmão. É derivado da casca do teixo do Pacífico (Taxus brevifolia) e é classificado como um taxano. Paclitaxel funciona estabilizando microtúbulos e prevenindo sua despolimerização, o que interrompe o processo normal de divisão celular, levando, em última instância, à apoptose nas células cancerosas. O composto é caracterizado por sua estrutura única, que inclui um sistema de anel de taxano e vários grupos funcionais que contribuem para sua atividade biológica. Paclitaxel é tipicamente administrado por via intravenosa e tem uma solubilidade relativamente baixa em água, muitas vezes exigindo formulação com solventes como Cremophor EL para uso clínico. Seus efeitos colaterais podem incluir neutropenia, reações de hipersensibilidade e neuropatia periférica. Devido à sua eficácia e mecanismo de ação, Paclitaxel continua sendo um pilar nas terapias oncológicas, embora seu uso seja frequentemente acompanhado de monitoramento cuidadoso e cuidados de suporte.

Fórmula: C₄₇H₅₁NO₁₄

InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

Chave InChI: InChIKey=RCINICONZNJXQF-MZXODVADSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Sinónimos:

• 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
• Abi 007
• Abraxane
• Anzatax
• Apealea
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bms 181339-01
• Capxol
• Coroflex Please
• Cremophor-free paclitaxel
• Cyclopax
• Cynviloq
• Cypher select
• Dhp 107
• Ebetaxel
• EmPAC
• EndoTAG 1
• Genaxol
• Genetaxyl
• Genexol
• Genexol-PM
• Ig 001
• Ig 002
• Infinnium
• Intaxel
• Lep-Etu
• Liposome-entrapped paclitaxel easy-to-use
• Mbt 0206
• Mitotax
• Nab-paclitaxel
• Nanotax
• Nanoxel
• Nk 105
• Nsc 125973
• OncoGel
• Onxal
• Oraxol
• Pacitaxel
• Pacliex
• Padexol
• Paxene
• Pazenir
• Plaxicel
• Qw 8184
• Sindaxel
• TAXUS Express
• TAXUS stent
• Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• TaxAlbin
• Taxal
• Taxol
• Taxol A
• Taxus
• Taxus Liberte
• Tocosol Paclitaxel

Paclitaxel

CAS: 33069-62-4

Fórmula: C₄₇H₅₁NO₁₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 853.92

Ref: 3B-P1632

Paclitaxel, 99.5+%

CAS: 33069-62-4

Paclitaxel, 33069-62-4, also known as Taxol, is an anticancer agent which acts through disruption of microtubule growth. Learn more at Thermo Fisher Scientific.

Fórmula: C₄₇H₅₁NO₁₄

Pureza: 99.5+%

Cor e Forma: White to cream, Crystalline powder or granular

Peso molecular: 853.92

Ref: 02-J62734

PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRS

CAS: 33069-62-4

PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRS

Fórmula: C₄₇H₅₁NO₁₄

Peso molecular: 853.9061

Ref: 41-Y0000700

PACLITAXEL CRS

CAS: 33069-62-4

PACLITAXEL CRS

Fórmula: C₄₇H₅₁NO₁₄

Cor e Forma: Crystalline Powder. White. Powder.

Peso molecular: 853.9061

Ref: 41-Y0000698

PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRS

CAS: 33069-62-4

PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0000739

PACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRS

CAS: 33069-62-4

PACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRS

Fórmula: C₄₇H₅₁NO₁₄

Peso molecular: 853.9061

Ref: 41-Y0000719

Paclitaxel

CAS: 33069-62-4

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₄₇H₅₁NO₁₄

Cor e Forma: White Off-White Powder

Peso molecular: 853.33096

Ref: 45-1491332

Paclitaxel

CAS: 33069-62-4

Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.

Fórmula: C₄₇H₅₁NO₁₄

Pureza: 98% - 99.92%

Cor e Forma: White Powder

Peso molecular: 853.91

Ref: TM-T0968

Paclitaxel

CAS: 33069-62-4

Paclitaxel

Pureza: ≥98%

Peso molecular: 853.91g/mol

Ref: 54-BUP20834

Paclitaxel

CAS: 33069-62-4

Fórmula: C₄₇H₅₁NO₁₄

Pureza: 97.0 - 102.0 % (anhydrous basis)

Cor e Forma: White powder

Peso molecular: 853.91

Ref: 7W-GA4564

Paclitaxel (Docetaxel EP Impurity F)

CAS: 33069-62-4

Fórmula: C₄₇H₅₁NO₁₄

Cor e Forma: White To Off-White Solid

Peso molecular: 853.92

Ref: 4Z-P-283

Paclitaxel

CAS: 33069-62-4

Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, and changes MT dynamics required for mitosis and cell proliferation. Paclitaxel can induce ototoxicity in rats.

Fórmula: C₄₇H₅₁NO₁₄

Pureza: 95%~99%

Peso molecular: 853.918

Ref: BP-BP1055

Paclitaxel, Taxus brevifolia

CAS: 33069-62-4

M02242 - Paclitaxel, Taxus brevifolia

Fórmula: C₄₇H₅₁NO₁₄

Pureza: >98%

Cor e Forma: Solid, Powder

Peso molecular: 853.918

Ref: 10-M02242

Paclitaxel

Produto Controlado

CAS: 33069-62-4

Fórmula: C₄₇H₅₁NO₁₄

Cor e Forma: Neat

Peso molecular: 853.91

Ref: 04-C15839000

Paclitaxel

Produto Controlado

CAS: 33069-62-4

Fórmula: C₄₇H₅₁NO₁₄

Cor e Forma: Neat

Peso molecular: 853.91

Ref: 86-MM1489.00

Paclitaxel (1mg×5)

CAS: 33069-62-4

Fórmula: C₄₇H₅₁NO₁₄

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 853.92

Ref: 3B-P3207

Paclitaxel from Taxus Mairei

CAS: 33069-62-4

Paclitaxel from Taxus Mairei

Fórmula: C₄₇H₅₁NO₁₄

Pureza: By hplc: consistent with structure (Typical Value in Batch COA)

Cor e Forma: solid

Peso molecular: 853.91g/mol

Ref: 54-BIP1002

Taxol

CAS: 33069-62-4

Oxygen-heterocyclic compound

Fórmula: C₄₇H₅₁NO₁₄

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 853.92

Ref: 5G-89806

Paclitaxel-13C6

Produto Controlado

CAS: 33069-62-4

Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Fórmula: C₄₁₁₃C₆H₅₁NO₁₄

Cor e Forma: Neat

Peso molecular: 859.86

Ref: TR-P132504

Paclitaxel

CAS: 33069-62-4

Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Fórmula: C₄₇H₅₁NO₁₄

Cor e Forma: Off-White

Peso molecular: 853.91

Ref: TR-P132500