CAS 33419-42-0
:Etoposídeo
Descrição:
Etoposídeo é um agente quimioterápico utilizado principalmente no tratamento de vários tipos de câncer, incluindo câncer testicular e câncer de pulmão de pequenas células. É classificado como um inibidor da topoisomerase II, o que significa que interfere na enzima responsável pela replicação e reparo do DNA, levando, em última instância, à morte das células cancerosas. Etoposídeo é tipicamente administrado por via intravenosa ou oral e é conhecido por sua eficácia em combinação com outros medicamentos quimioterápicos. O composto tem uma fórmula molecular de C21H22O8 e um peso molecular de aproximadamente 366,39 g/mol. Etoposídeo é caracterizado por sua capacidade de induzir apoptose em células cancerosas, tornando-se uma ferramenta valiosa em oncologia. No entanto, também pode causar efeitos colaterais, incluindo mielossupressão, distúrbios gastrointestinais e aumento do risco de malignidades secundárias. Devido ao seu mecanismo de ação, o monitoramento e a gestão cuidadosa da dosagem são essenciais para minimizar a toxicidade enquanto se maximiza a eficácia terapêutica. No geral, Etoposídeo continua sendo um agente importante no arsenal contra certas malignidades.
Fórmula:C29H32O13
InChI:InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
Chave InChI:InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@H](C)OC5)[H])[H])[C@]2(CO1)[H])=CC6=C(C3)OCO6)C7=CC(OC)=C(O)C(OC)=C7)[H]
Sinónimos:- (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-alpha-L-gulopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-mannopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-alpha-L-gulopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-beta-D-mannopyranoside
- (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
- 4'-Demethyl-1-O-[4,6-O-(ethylidene)-β-D-glucopyranosyl]epipodophyllotoxin
- 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
- 4'-Demethylepipodophyllotoxin ethylidene-β-D-glucoside
- 4'-Demethylepipodophyllotoxin-(4,6-O-(R)-Ethylidene-Beta-D-Glucopyranoside)
- 4-Demethylepipodophyllotoxin-Beta-D-Ethylideneglucoside
- 4′-Demethyl-1-O-[4,6-O-(ethylidene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]epipodophyllotoxin
- 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
- 4′-Demethylepipodophyllotoxin ethylidene-β-<span class="text-smallcaps">D</span>-glucoside
- Beposid
- Bioposide
- Celltop
- EPE
- Epipodophyllotoxin VP 16213
- Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-β-D-glucopyranoside
- Epipodophyllotoxin, 4′-demethyl-, 4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside
- Eposed
- Eposin
- Ethopul
- Eto-Gry
- Etoposid
- Etoposido
- Etosid
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahy dro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
- Fytop
- Fytosid
- Lastet
- Nsc 141540
- Nzytop
- Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
- Sintopozid
- Topok
- Toposar
- Toposide
- VP 16 (pharmaceutical)
- VePesid
- Vepesid J
- Vp 16
- Vp 16-123
- Vp 16-213
- Zuyeyidal
- trans-Etoposide
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
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Etoposide
CAS:Fórmula:C29H32O13Pureza:>98.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:588.56Etoposide
CAS:<p>Topoisomerase inhibitor and inducer of apoptosis</p>Fórmula:C29H32O13Cor e Forma:Powder or crystals or crystalline powderPeso molecular:588.56ETOPOSIDE FOR SYSTEM SUITABILITY CRS
CAS:<p>ETOPOSIDE FOR SYSTEM SUITABILITY CRS</p>Fórmula:C29H32O13Peso molecular:588.5566ETOPOSIDE CRS
CAS:<p>ETOPOSIDE CRS</p>Fórmula:C29H32O13Cor e Forma:Crystalline Powder. White. Powder.Peso molecular:588.5566Etoposide Resolution Mixture
CAS:<p>Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives</p>Cor e Forma:White PowderEtoposide
CAS:<p>Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives</p>Fórmula:C29H32O13Cor e Forma:White Off-White PowderPeso molecular:588.18429Etoposide
CAS:<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Fórmula:C29H32O13Pureza:99.19% - 99.94%Cor e Forma:Crystals From Methanol SolidPeso molecular:588.56(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
CAS:Fórmula:C29H32O13Pureza:98%Cor e Forma:SolidPeso molecular:588.5566Etoposide
CAS:Fórmula:C29H32O13Pureza:(HPLC) ≥ 98.0%Cor e Forma:White or almost white crystalline powderPeso molecular:588.56Etoposide, USP grade
CAS:Fórmula:C29H32O13Pureza:(anhydrous basis) 95.0 - 105.0 %Cor e Forma:White or almost white crystalline powderPeso molecular:588.56Etoposide
CAS:Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, it induces apoptosis in MCF-7 breast cancer cells.Fórmula:C29H32O13Pureza:95%~99%Peso molecular:588.562Etoposide
CAS:<p>Etoposide</p>Fórmula:C29H32O13Pureza:99%Cor e Forma: pale yellow solidPeso molecular:588.56g/molEtoposide-d4
CAS:Produto Controlado<p>Applications Etoposide-d4, is the labeled analogue of Etoposide (E933750), a DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. Antineoplastic.<br>References Burden, D.A., et al.: J. Biol. Chem., 271, 29238 (1996), Joel, S., et al.: Cancer Treat. Rev., 22, 179 (1996),<br></p>Fórmula:C29H28D4O13Cor e Forma:NeatPeso molecular:592.58
![(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA003A2V.jpg&w=3840&q=75)
