CAS 34031-32-8
:Auranofin
Descrição:
Auranofin é um composto que contém ouro, utilizado principalmente no tratamento da artrite reumatoide. Pertence à classe de medicamentos conhecidos como sais de ouro, que possuem propriedades anti-inflamatórias. A fórmula química de Auranofin é C20H17AuO9PS, indicando que contém ouro, enxofre, fósforo e vários componentes orgânicos. Auranofin funciona modulando a resposta imunológica e inibindo a atividade de certas enzimas envolvidas na inflamação. Geralmente é administrado por via oral e é conhecido por sua toxicidade relativamente baixa em comparação com outros compostos de ouro. No entanto, ainda pode causar efeitos colaterais, incluindo distúrbios gastrointestinais e possíveis reações alérgicas. O mecanismo de ação do composto envolve a inibição da ativação de macrófagos e a modulação da produção de citocinas, contribuindo para seus efeitos terapêuticos. Auranofin também despertou interesse na pesquisa por suas potenciais aplicações além da artrite, incluindo suas propriedades antiparasitárias e anticancerígenas. Assim como qualquer medicamento, seu uso deve ser monitorado por profissionais de saúde para gerenciar eficazmente quaisquer efeitos adversos.
Fórmula:C20H34AuO9PS
InChI:InChI=1/C6H15P.Au/c1-4-7(5-2)6-3;/h4-6H2,1-3H3;/q;+1
Chave InChI:InChIKey=AUJRCFUBUPVWSZ-XTZHGVARSA-M
SMILES:O(C(C)=O)[C@@H]1[C@@H](OC(C)=O)[C@H]([S-][Au+][P](CC)(CC)CC)O[C@H](COC(C)=O)[C@H]1OC(C)=O
Sinónimos:- (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
- 3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydropyran-2-Thiolate
- Aktil
- Auranofina
- Auranofine
- Crisinor
- Crisofin
- Gold Salt
- Gold(+1) Cation
- Gold, (1-thio-β-<span class="text-smallcaps">D</span>-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate
- Gold, (1-thio-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-
- Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate
- Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-
- Gold, [1-(thio-κS)-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-
- Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-
- Nsc 321521
- Phosphine, Triethyl-, Gold(1+) Salt (1:1)
- Ridaura
- Ridauran
- Skf 39162
- Skf 39162D
- Triethylphosphonium
- [(Tetra-O-acetyl-β-<span class="text-smallcaps">D</span>-glucopyranosyl)thio](triethylphosphine)gold
- [(Tetra-O-acetyl-β-D-glucopyranosyl)thio](triethylphosphine)gold
- [1-(Thio-κS)-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold
- β-<span class="text-smallcaps">D</span>-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex
- β-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex
- [1-(Thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold
- 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium
- gold,(1-thio-beta-d-glucopyranose2,3,4,6-tetraacetato-s)(triethylphosphine)
- Gold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)-
- sk&f39162
- 2,3,4,6-tetra-o-acetyl-1-thio-beta-d-glucopyranosato-s(triethylphosphine)gol
- sk&f39162d
- (1-thio-beta-d-glucopyranosato)-(triethylphosphine)gold2,3,4,6-tetraacetate
- (1-Thio-β-D-glucopyranosato)(triethylphosphine)gold-2，3，4，6-tetraacetate
- gold,(1-thio-beta-d-glucopyranosato-s)(triethylphosphine)-,2,3,4,6-tetraaceta
- AURANOFIN
- sk&fd-39162
- Adtil
- Auranofin, >=98%
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9 produtos.
(1-Thio-β-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
CAS:Fórmula:C20H34AuO9PSPureza:98%Cor e Forma:SolidPeso molecular:678.4839Ref: IN-DA00382F
1gA consultar1mg52,00€10mg89,00€50mg168,00€100mg271,00€250mgA consultar500mgA consultarAuranofin
CAS:<p>Auranofin (SKF-39162), an antirheumatic, treats rheumatoid arthritis and eases joint pain and stiffness.</p>Fórmula:C20H34AuO9PSPureza:97% - 99.01%Cor e Forma:White Crystalline Powder SolidPeso molecular:678.49((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2-Thio)(Triethylphosphine)Gold
CAS:<p>((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2-Thio)(Triethylphosphine)Gold</p>Pureza:98%Peso molecular:678.5g/molAuranofine
CAS:Fórmula:C20H34AuO9PSPureza:≥ 95.0%Cor e Forma:White to off-white solidPeso molecular:678.48Auranofin
CAS:<p>Auranofin is a chrysotherapeutic agent which inhibits histamine release from human basophils. Auranofin is gold-containing salt extensively used in the treatment of rheumatoid arthritis. Auranofin has antimicrobial properties and inhibits the growth of Clostridium difficile more effectively than vancomycin and metronidazole. According to in vitro studies carried out in 2020, auranofin inhibits the replication of coronavirus SARS-CoV-2 and reduces inflammation in human cells.</p>Fórmula:C20H34AuO9PSCor e Forma:White Off-White PowderPeso molecular:678.49 g/molAuranofin
CAS:Produto Controlado<p>Applications Auranofin is a new oral gold-based antiarthritis drug. Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kizu, R., et al.: Chem. Pharm. Bull., 41, 1261 (1993), Itokazu, M., et al.: Clin. Ther., 17, 60 (1995), Kean, W.F., et al.: Br. J. Rheumatol., 36, 560 (1997),<br></p>Fórmula:C20H34AuO9PSCor e Forma:NeatPeso molecular:678.48
