CAS 34381-68-5

Cloridrato de acebutolol

Descrição:

Cloridrato de acebutolol é um antagonista seletivo dos receptores beta-1 adrenérgicos, utilizado principalmente no tratamento da hipertensão e em certas condições cardíacas. É caracterizado pela sua capacidade de reduzir a frequência cardíaca e a contratilidade miocárdica, tornando-o eficaz no controle da pressão arterial elevada e na prevenção da angina. O composto é tipicamente administrado por via oral e é conhecido por sua meia-vida relativamente longa, permitindo a dosagem uma ou duas vezes ao dia. Cloridrato de acebutolol é um pó cristalino branco a branco sujo, solúvel em água e álcool, o que facilita sua formulação em várias formas de dosagem. Seu mecanismo de ação envolve o bloqueio dos receptores beta-1 no coração, levando a uma diminuição do débito cardíaco e a uma pressão arterial mais baixa. Além disso, possui atividade simpaticomimética intrínseca, o que significa que pode estimular parcialmente os receptores beta enquanto os bloqueia, potencialmente resultando em menos efeitos colaterais em comparação com betabloqueadores não seletivos. Assim como qualquer medicamento, é importante monitorar os possíveis efeitos colaterais, incluindo bradicardia e fadiga, e considerar contraindicações em pacientes com certas condições pré-existentes.

Fórmula: C₁₈H₂₉ClN₂O₄

InChI: InChI=1/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H

Chave InChI: InChIKey=KTUFKADDDORSSI-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=C(C(C)=O)C=C(NC(CCC)=O)C=C1.Cl

Sinónimos:

• (+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide monohydrochloride
• (1)-N-(3-Acetyl-4-(2-hydroxy-3-((isopropyl)amino)propoxy)phenyl)butyramide monohydrochloride
• 3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide hydrochloride
• 3-[2-acetyl-4-(butanoylamino)phenoxy]-2-hydroxy-N-(propan-2-yl)propan-1-aminium chloride
• <span class="text-smallcaps">DL</span>-1-(2-Acetyl-4-butyramido)-3-(isopropylamino)propan-2-ol hydrochloride
• <span class="text-smallcaps">DL</span>-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
• Acebutolol HCl
• Acebutolol hydrochloride [JAN]
• Acetanol
• Acetobutolol hydrochloride
• Butanamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, monohydrochloride, (+-)-
• Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, hydrochloride (1:1)
• Butyranilide, 3'-acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)-, monohydrochloride, (+-)-
• Ccris 1102
• Diasectral
• Hsdb 6524
• Il 17803A
• M and B 17803A
• M&B 17,803A
• Neptall
• Sectral
• Unii-B025Y34C54
• Wesfalin
• dl-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
• ACEBUTOLOL HYDROCHLORIDE, IMPURITY IN-[3-ACETYL-4-[(2RS)-3-(ETHYLAMINO)-2-HYDROXYPROPOXY]PHENYL)BUTANAMIDE EP STANDARD
• N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide Hydrochloride
• n-[3-acetyl-4-[2-hydroxy-3-[(isopropyl)amino]propoxy]phenyl]butyramide hydrochloride
• ACEBUTOLOL HYDROCHLORIDE
• 3’-acetyl-4’-(2-hydroxy-3-(isopropylamino)propoxy)butyranilidehydrochloride
• (±)-N-[3-acetyl-4-[2-hydroxy-3-[(isopropyl)amino]propoxy]phenyl]butyramide monohydrochloride
• ACEBUTOLOL HYDROCHLORIDE, EP STANDARD
• acetobutololhydrochloride
• ACEBUTOLOL HYDROCHLORIDE, USP STANDARD
• Acecor
• 3’-acetyl-4’-(2-hydroxy-3-(isopropylamino)propoxy)-butyranilidmonohydrochl
• m&b17,803a
• ACEBUTOLOL HYDROCHLORIDE, IMPURITY CN-(3-ACETYL-4-HYDROXYPHENYL)BUTANAMIDE EP STANDARD
• dl-1-(2-acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropanehydroch
• N-[3-ACETYL-4-(2-HYDROXY-3-[ISOPROPYLAMINO]PROPOXY)PHENYL]-BUTANAMIDE HYDROCHLORIDE
• ACEBUTOLOL HYDROCHLORIDE, MM(CRM STANDARD)

Acebutolol Hydrochloride

CAS: 34381-68-5

Cor e Forma: Neat

Ref: 61-FOR0435.00

Acebutolol Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 34381-68-5

Cor e Forma: Single Solution

Ref: 61-AMP0435.00-01

ACEBUTOLOL HYDROCHLORIDE CRS

CAS: 34381-68-5

ACEBUTOLOL HYDROCHLORIDE CRS

Fórmula: C₉H₁₇NO

Cor e Forma: White. Whitish. Crystalline Powder. Powder.

Peso molecular: 155.2374

Ref: 41-A0040000

Acebutolol Hydrochloride

CAS: 34381-68-5

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Fórmula: C₁₈H₂₈N₂O₄·HCl

Cor e Forma: White Off-White Powder

Peso molecular: 372.89

Ref: 45-1000601

DL-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride

CAS: 34381-68-5

Fórmula: C₁₈H₂₉ClN₂O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 372.8869

Ref: IN-DA007FXT

Acebutolol hydrochloride

CAS: 34381-68-5

Acebutolol HCl: cardioselective beta-blocker, minimal bronchial impact, intrinsic sympathomimetic, treats hypertension & ventricular arrhythmias.

Fórmula: C₁₈H₂₉ClN₂O₄

Pureza: 99.92% - >99.99%

Cor e Forma: White Or Slightly Off-White Crystalline Powder Solid

Peso molecular: 372.89

Ref: TM-T1012

Acebutolol-d7

CAS: 34381-68-5, 37517-30-9

Fórmula: C₁₈H₂₁D₇N₂O₄

Cor e Forma: White To Off-White Solid

Peso molecular: 343.47

Ref: 4Z-A-169012

Acebutolol Hydrochloride

CAS: 34381-68-5

Cor e Forma: Neat

Ref: 86-MM0435.00

Acebutolol hydrochloride

Produto Controlado

CAS: 34381-68-5

Fórmula: C₁₈H₂₈N₂O₄·ClH

Cor e Forma: Neat

Peso molecular: 372.89

Ref: 04-C10005150

Acebutolol Hydrochloride

CAS: 34381-68-5

Applications Cardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Cuthbert, O.A., et al.: Br. J. Pharmacol., 43, 639 (1971), Singh, B.N., et al.: Drugs, 29, 531 (1985), Foster, R.T., et al.: Anal. Profiles Drug Subs., 19, 1 (1990),

Fórmula: C₁₈H₂₉ClN₂O₄

Cor e Forma: White to Pale Yellow Solid

Peso molecular: 372.89

Ref: TR-A123800

Acebutolol hydrochloride

Produto Controlado

CAS: 34381-68-5

Acebutolol is a non-selective beta-blocker that is used for the treatment of hypertension and other conditions. It inhibits the ryanodine receptor and prevents calcium release, which has been shown to be responsible for the contraction of cardiac muscle. Acebutolol also inhibits phosphodiesterase, which leads to increased levels of cyclic adenosine monophosphate (cAMP) in cells. In addition, acebutolol has been shown to inhibit the production of inflammatory mediators by inhibiting prostaglandin synthesis. The most common adverse effects include drowsiness, dizziness, fatigue, and headache. Acebutolol hydrochloride can be found in wastewater as a result of its use in humans and animals. This drug can be detected in wastewater using solid phase microextraction followed by gas chromatography/mass spectrometry (GC/MS).

Fórmula: C₁₈H₂₈N₂O₄•HCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 372.89 g/mol

Ref: 3D-FA16907

Acebutolol hydrochloride

CAS: 34381-68-5

Cardioselective beta-adrenergic blocker This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Fórmula: C₁₈H₂₈N₂O₄•HCl

Cor e Forma: Powder or crystals or crystalline powder, White to off-white

Peso molecular: 372.89

Ref: 02-J63790