CAS 34580-14-8

fumarato de cetotifeno

Descrição:

fumarato de cetotifeno é um composto farmacêutico utilizado principalmente como antihistamínico e estabilizador de mastócitos, frequentemente prescrito para o manejo de condições alérgicas como asma e rinite alérgica. É um derivado do composto cetotifeno, conhecido por sua capacidade de inibir a liberação de histamina e outros mediadores dos mastócitos. fumarato de cetotifeno é tipicamente apresentado como um pó cristalino branco a off-white, que é solúvel em água e exibe um perfil relativamente estável sob condições de armazenamento padrão. A forma de sal de fumarato melhora sua solubilidade e biodisponibilidade. O composto atua bloqueando os receptores H1 de histamina e possui propriedades anti-inflamatórias adicionais, tornando-o eficaz na redução da hiperreatividade brônquica. Sua farmacocinética envolve administração oral, com uma meia-vida notável que permite a dosagem uma ou duas vezes ao dia. Assim como qualquer medicamento, os efeitos colaterais potenciais podem incluir sedação, boca seca e distúrbios gastrointestinais, exigindo consideração cuidadosa em pacientes com condições de saúde específicas.

Fórmula: C₂₃H₂₃NO₅S

InChI: InChI=1/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

Chave InChI: InChIKey=YNQQEYBLVYAWNX-WLHGVMLRSA-N

SMILES: O=C1C2=C(C(C=3C(C1)=CC=CC3)=C4CCN(C)CC4)C=CS2.C(=C/C(O)=O)\C(O)=O

Sinónimos:

• 1-methyl-4-(10-oxo-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidinium
• 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)
• 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1)
• 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
• 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one fumarate (1:1)
• 4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
• 4,9-Dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophene-10-one fumarate
• 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
• 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-but-2-enedioate
• Alaway
• Allerkif
• HC 20,511 fumarate
• Hc 20511
• Ketotifen fumarate [USAN:JAN]
• Ketotifen hydrogen fumarate
• Totifen
• Unii-Hbd503Woro
• Zaditen
• Zaditor
• Zasten
• fumarate de 4,9-dihydro-4-(1-methylpiperidine-4-ylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophene-10-one
• fumarato de 4,9-dihidro-4-(1-metilpiperidin-4-ilideno)-10H-benzo[4,5]ciclohepta[1,2-b]tiofeno-10-ona
• Ketotifen fumarate
• 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-pipe
• KETOTIFEN FUMARATE EP
• KETOTIFEN FUMARATE SALT
• 4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9h)-one hydrogen fumarate
• Ketotifene fumarate
• 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
• Anatifen
• hc20-511fumarate

Ketotifen Fumarate

CAS: 34580-14-8

Fórmula: C₁₉H₁₉NOS·C₄H₄O₄

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 425.50

Ref: 3B-K0048

Ketotifen fumarate, 99%

CAS: 34580-14-8

Ketotifen fumaratin is an H1 receptor antagonist. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label infor

Fórmula: C₂₃H₂₃NO₅S

Pureza: 99%

Cor e Forma: White to pale cream to pale yellow, Powder

Peso molecular: 425.50

Ref: 02-J63708

Ketotifen Hydrogen Fumarate 1.0 mg/ml in Methanol (as free base)

CAS: 34580-14-8

Cor e Forma: Single Solution

Ref: 61-AMP0180.00-01

Ketotifen Hydrogen Fumarate

CAS: 34580-14-8

Cor e Forma: Neat

Ref: 61-FOR0180.00

KETOTIFEN HYDROGEN FUMARATE CRS

CAS: 34580-14-8

KETOTIFEN HYDROGEN FUMARATE CRS

Fórmula: C₂₃H₂₃NO₅S

Cor e Forma: White. Yellow-Brown. Crystalline Powder.

Peso molecular: 425.4974

Ref: 41-Y0001619

Ketotifen Fumarate

CAS: 34580-14-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₉H₁₉NOS·C₄H₄O₄

Cor e Forma: White Brownish Yellow Powder

Peso molecular: 309.11874

Ref: 45-1356406

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

Fórmula: C₂₃H₂₃NO₅S

Pureza: 99.25% - 99.73%

Cor e Forma: Solid

Peso molecular: 425.50

Ref: TM-T0994

10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)

CAS: 34580-14-8

Fórmula: C₂₃H₂₃NO₅S

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 425.4974

Ref: IN-DA003R69

Ketotifen Fumarate

CAS: 34580-14-8

Fórmula: C₁₉H₁₉NOS·C₄H₄O₄

Cor e Forma: Off-White Solid

Peso molecular: 309.43 116.07

Ref: 4Z-K-061

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate

Pureza: ≥95%

Peso molecular: 425.5g/mol

Ref: 54-BUP14763

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate

Fórmula: C₁₉H₁₉NOS·C₄H₄O₄

Pureza: 99.7% (hplc) (Typical Value in Batch COA)

Cor e Forma: Solid

Peso molecular: 425.50g/mol

Ref: 54-BIK4000

Ketotifen fumarate

CAS: 34580-14-8

Fórmula: C₁₉H₁₉NOS·C₄H₄O₄

Pureza: ≥ 98%

Cor e Forma: White to off-white powder

Peso molecular: 425.50

Ref: 7W-GP2795

Ketotifen Hydrogen Fumarate

Produto Controlado

CAS: 34580-14-8

Fórmula: C₁₉H₁₉NOS·C₄H₄O₄

Cor e Forma: Neat

Peso molecular: 425.50

Ref: 86-MM0180.00

Ketotifen Fumarate

Produto Controlado

CAS: 34580-14-8

Applications Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent.
References Tsuji, F., et al.: Biol. Pharm. Bull., 33, 1050 (2010), Al O., et al.: J., Mol., Liq., 155, 103 (2010), Uccello-Barretta, G., et al.: Int. J. Pharm., 395, 122 (2010),

Fórmula: C₁₉H₁₉NOS·C₄H₄O₄

Cor e Forma: White

Peso molecular: 425.50

Ref: TR-K315100

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate is an anti-inflammatory drug that belongs to the class of histamine H1 receptor antagonists. It has been shown to be effective in the treatment of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Ketotifen fumarate also has biological properties, such as eosinophil cationic protein release inhibition, that are important for its therapeutic effects. In vitro studies have shown that ketotifen fumarate can inhibit h1-receptor mediated responses in a dose-dependent manner. The drug is metabolized by the liver enzyme CYP3A4 and has been shown to interact with other drugs metabolized through this pathway. Ketotifen fumarate is currently being used as a research tool in experimental models of infectious diseases, such as tuberculosis and influenza A virus infection.

Fórmula: C₂₃H₂₃NO₅S

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 425.5 g/mol

Ref: 3D-FK01539