CAS 345909-35-5

Ácido 4-hidroxiquinolina-2-carboxílico hidratado

Descrição:

Ácido 4-hidroxiquinolina-2-carboxílico hidratado é um composto orgânico caracterizado por sua estrutura de quinolina, que apresenta um grupo hidroxila e um grupo funcional de ácido carboxílico. Este composto geralmente aparece como um sólido cristalino e é conhecido por suas potenciais aplicações em farmacêutica e bioquímica, particularmente como um bloco de construção na síntese de várias moléculas bioativas. A presença do grupo hidroxila contribui para sua solubilidade em solventes polares, enquanto o grupo ácido carboxílico pode participar de ligações de hidrogênio e outras interações, aumentando sua reatividade. A forma hidratada indica que contém moléculas de água em sua estrutura cristalina, o que pode influenciar suas propriedades físicas, como ponto de fusão e solubilidade. Além disso, Ácido 4-hidroxiquinolina-2-carboxílico hidratado pode exibir atividade biológica, tornando-o de interesse em química medicinal e pesquisa relacionada a propriedades antimicrobianas ou anti-inflamatórias. Assim como muitos compostos orgânicos, o manuseio e armazenamento adequados são essenciais para manter sua estabilidade e eficácia.

Fórmula: C₁₀H₆NO₃

InChI: InChI=1/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1

SMILES: c1ccc2c(c1)c(=O)cc(C(=O)[O-])[nH]2

Sinónimos:

• 4-hydroxy-Quinaldate
• 4-Hydroxyquinaldate
• 4-Hydroxyquinaldinate
• 4-Hydroxyquinoline-2-carboxylate
• Kynurenate
• 4-Oxo-1,4-Dihydroquinoline-2-Carboxylate

Kynurenic Acid

CAS: 345909-35-5, 492-27-3

Fórmula: C₁₀H₇NO₃

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Gray to Brown powder to crystal

Peso molecular: 189.17

Ref: 3B-H0303

4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

CAS: 345909-35-5

Broad spectrum excitatory amino acid antagonist4-Hydroxyquinoline-2-carboxylic acid hydrate is used as an intermediate in synthetic chemistry. It acts as an antiexcitotoxic and anticonvulsant. It finds application in certain neurobiological disorders therapy. This Thermo Scientific Chemicals brand

Fórmula: C₁₀H₇NO₃

Pureza: 98%

Cor e Forma: Dark cream to cream to yellow to green to pale brown to pale gray to gray, Powder

Peso molecular: 189.17

Ref: 02-A12602

4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID, HYDRATE, 98

CAS: 345909-35-5

Fórmula: C₁₀H₉NO₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 207.1828

Ref: IN-DA003LJW

4-Hydroxyquinoline-2-carboxylic acid hydrate

CAS: 345909-35-5

4-Hydroxyquinoline-2-carboxylic acid hydrate

Fórmula: C₁₀H₇NO₃·H₂O

Pureza: ≥95%

Cor e Forma: faint yellow/ green solid

Peso molecular: 207.18g/mol

Ref: 54-OR12784

4-Hydroxyquinoline-2-carboxylic acid hydrate

CAS: 345909-35-5

4-Hydroxyquinoline-2-carboxylic acid hydrate is a neuroprotective agent that has been shown to be effective in the treatment of neurodegenerative diseases. It is a solvate, which means that it can form crystals with water molecules and is capable of hydrogen bonding. The quinolinecarboxylic acid moiety of 4-hydroxyquinoline-2-carboxylic acid hydrate has been shown to have neuroprotective effects against neurotoxicity induced by kynurenic acid, an endogenous compound. 4-Hydroxyquinoline-2-carboxylic acid hydrate has broad spectrum activity and can be used as a broad spectrum neuroprotective agent. The molecule also displays polymorphism with tautomeric behaviour and diffraction properties.

Fórmula: C₁₀H₇NO₃·H₂O

Pureza: Min. 95%

Peso molecular: 189.17 g/mol

Ref: 3D-VNA90935

Kynurenic Acid hydrate

CAS: 345909-35-5

Kynurenic acid, an active metabolite of tryptophan, is synthesized through a kynurenine intermediate by kynurenine aminotransferases (KATs). It acts as an antagonist of both NMDA and AMPA receptors, as well as α7 nicotinic acetylcholine receptors (nAChRs; EC50s = 235, 101, and 7 µM, respectively), and functions as an agonist for the aryl hydrocarbon receptor (AhR) and G protein-coupled receptor 35 (GPR35; EC50s = 1.4 and 39 µM, respectively). In a neonatal rat model of cerebral hypoxic-ischemia, induced by carotid artery ligation, administration of kynurenic acid at 300 mg/kg prevents weight loss in the lesioned hemisphere. Additionally, at concentrations of 1 and 5 mg/ml, it protects against neurodegeneration in the rhabdomere of the eye in an Htt93QtransgenicDrosophila model of Huntington's disease. Elevated levels of kynurenic acid in the cerebrospinal fluid have been observed in patients with schizophrenia.

Fórmula: C₁₀H₉NO₄

Cor e Forma: Solid

Peso molecular: 207.185

Ref: TM-T84434