CAS 347841-46-7

Ácido (3α,5β,7β)-3,7-diidroxicolan-24-oico-2,2,4,4-d4

Descrição:

A substância química conhecida como "Ácido (3α,5β,7β)-3,7-diidroxicolan-24-oico-2,2,4,4-d4," com o número CAS 347841-46-7, é um derivado de ácidos biliares, especificamente uma forma modificada do ácido cólico. Este composto apresenta grupos hidroxila nas posições 3 e 7 do núcleo esteroide, que são críticos para sua atividade biológica e solubilidade. A presença de deutério (d4) indica que certos átomos de hidrogênio na molécula foram substituídos por isótopos de deutério, o que pode ser útil em estudos de rastreamento e pesquisa metabólica. As modificações estruturais contribuem para suas propriedades únicas, influenciando sua interação com sistemas biológicos, incluindo seu papel no metabolismo lipídico e potenciais aplicações terapêuticas. Como um derivado de ácido biliar, também pode desempenhar um papel na emulsificação de gorduras e auxiliar na digestão. No geral, este composto exemplifica a complexidade da química esteroide e suas implicações em bioquímica e farmacologia.

Fórmula: C₂₄H₄₀O₄

InChI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1/i8D2,12D2

Chave InChI: InChIKey=RUDATBOHQWOJDD-QGCKUCIHSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@@H]3O)(C([C@H](O)C(C4)([2H])[2H])([2H])[2H])[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Sinónimos:

• (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,4,4-d₄ acid
• Cholan-24-oic-2,2,4,4-d₄ acid, 3,7-dihydroxy-, (3α,5β,7β)-
• Ursodeoxycholic-2,2,4,4-D4 Acid
• Cholan-24-oic-2,2,4,4-d4 acid, 3,7-dihydroxy-, (3α,5β,7β)-
• (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,4,4-d4 acid
• Ursodeoxycholic Acid-d4 MaxSpec? Standard
• Ursodeoxycholic-d4 Acid
• URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 95% CHEMICAL PURITY
• Urosodeoxycholic Acid Impurity 28
• (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• Ursodeoxycholic acid-[d4] (Solution)
• Ursodeoxycholic Acid-2,2,4,4-d4 (Major)
• Ursodiol-d4 (Ursodeoxycholic Acid-d4)
• URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL
• (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,14S,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

Ursodiol-d4 (Ursodeoxycholic Acid-d4)

CAS: 347841-46-7

Fórmula: C₂₄H₃₆D₄O₄

Cor e Forma: White To Off-White Solid

Peso molecular: 396.60

Ref: 4Z-U-021

Ursodeoxycholic Acid-d4

CAS: 347841-46-7

Ursodeoxycholic Acid-d4

Pureza: ≥98%

Peso molecular: 396.6g/mol

Ref: 54-BUP01116

Ursodeoxycholic-2,2,4,4-d4Acid

CAS: 347841-46-7

Pureza: 98 atom % D

Cor e Forma: White Solid

Peso molecular: 396.60

Ref: 3U-D3819

Ursodeoxycholic Acid-d4

CAS: 347841-46-7

Ursodeoxycholic Acid-d4 (Ursodeoxycholic acid-2,2,4,4-d4) is the deuterium substituent of Ursodeoxycholic acid.

Fórmula: C₂₄H₄₀O₄

Pureza: 99.75%

Cor e Forma: Solid

Peso molecular: 396.6

Ref: TM-TMIH-0590

Ursodeoxycholic Acid-d4 (Major)

Produto Controlado

CAS: 347841-46-7

Fórmula: C₂₄₂H₄H₃₆O₄

Cor e Forma: White To Off-White

Peso molecular: 396.60

Ref: TR-U850003

Ursodeoxycholic Acid-d4

Produto Controlado

CAS: 347841-46-7

Applications Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.
References Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986), Poupon, R.E, et al.: N. Engl. J. Med., 324, 1548 (1991), MacKenzie, P., et al.: J. Biol. Chem., 283, 36205 (2008); Scherer, M., et al.: J. Chromatogr. B, 877, 3920 (2009(

Fórmula: C₂₄₂H₄H₃₆O₄

Cor e Forma: White To Off-White

Peso molecular: 396.60

Ref: TR-U850007

Ursodeoxycholic acid-D4

Produto Controlado

CAS: 347841-46-7

Ursodeoxycholic acid (UDCA) is a bile acid that belongs to the group of secondary bile acids. UDCA is used in the treatment of gallstones, primary biliary cirrhosis, and cholestatic liver diseases. UDCA is also used in the treatment of malignant tumours due to its ability to reduce cholesterol levels. Ursodeoxycholic acid-D4 has been shown to have a beneficial effect on serum cholesterol levels and has a protective effect against liver fibrosis and hepatocarcinogenesis. UDCA-D4 has been shown to be effective for the diagnosis of pancreatic cancer, hepatobiliary cancer, and bilirubin concentration. UDCA-D4 also improves the prognosis of patients with pancreatic cancer.

Fórmula: C₂₄H₃₆D₄O₄

Pureza: Min. 95%

Peso molecular: 396.6 g/mol

Ref: 3D-XNA84146