CAS 357-08-4

Cloridrato de naloxona

Descrição:

Cloridrato de naloxona é um antagonista opioide usado principalmente na medicina de emergência para contrabalançar a overdose de opioides. É um pó cristalino branco a off-white que é solúvel em água, tornando-o adequado para administração intravenosa, intramuscular ou subcutânea. A fórmula química de Cloridrato de naloxona é C19H21NO4•HCl, e tem um peso molecular de aproximadamente 343,84 g/mol. Este composto atua ligando-se competitivamente aos receptores opioides no sistema nervoso central, revertendo efetivamente os efeitos dos opioides, como depressão respiratória e sedação. A naloxona tem um início de ação rápido, tipicamente dentro de minutos, e seus efeitos podem durar de 30 a 90 minutos, dependendo da dose e da via de administração. É importante notar que a naloxona não é eficaz contra overdoses de drogas não opioides e pode precipitar sintomas de abstinência em indivíduos dependentes de opioides. Cloridrato de naloxona é uma ferramenta crítica na saúde pública para prevenir fatalidades relacionadas a opioides e muitas vezes está disponível em várias formulações, incluindo autoinjetores e sprays nasais.

Fórmula: C₁₉H₂₂ClNO₄

InChI: InChI=1/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1

Chave InChI: InChIKey=RGPDIGOSVORSAK-STHHAXOLSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC=C)CC4)[H].Cl

Sinónimos:

• (-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride
• (5Alpha)-3,14-Dihydroxy-17-Prop-2-En-1-Yl-4,5-Epoxymorphinan-6-One Hydrochloride
• En 1530
• En 15304
• Morphinan-6-one, 17-allyl-4,5α-epoxy-3,14-dihydroxy-, hydrochloride
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, hydrochloride (1:1), (5α)-
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5α)-
• N-Allyldihydro-14-hydroxynormorphinone hydrochloride
• Nalone
• Nalonee
• Naloxone HCl
• Narcan
• Narcanti
• Narcoxone
• Nih 7890
• Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-, hydrochloride
• l-Naloxone hydrochloride
• 17-allyl-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydrochloride
• 17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-onehydrochloride
• en1530
• (5alpha)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
• 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride
• (5ALPHA)-4,5-EPOXY-3,14-DIHYDRO-17-(2-PROPENYL)MORPHINAN-6-ONE HYDROCHLORIDE
• l-n-allyl-14-hydroxynordihydromorphinonehydrochloride
• morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,hydrochloride,(5-a
• NALOXONE HYDROCHLORIDE CRYSTALLINE
• NALOXONE HYDROCHLORIDE OPIOID ANTAGONIST
• nih7890
• (5a)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one Hydrochloride
• NALOXONE HYDROCHLORIDE

Naloxone hydrochloride, 98%

CAS: 357-08-4

Naloxone hydrochloride, 357-08-4, is a salt form of naloxone, a specific opioid antagonist which competitively binds to opioid receptors in the central nervous system. Learn more.

Fórmula: C₁₉H₂₂ClNO₄

Pureza: 98%

Cor e Forma: White to off-white, Crystals or powder or crystalline powder

Peso molecular: 363.84

Ref: 02-J60013

Naloxone hydrochloride

CAS: 357-08-4

Naloxone hydrochloride

Fórmula: C₁₉H₂₁NO₄HCl

Pureza: 90.6%

Cor e Forma: White To Off-White

Peso molecular: 363.12374

Ref: 47-548

Naloxone HCl

CAS: 357-08-4

Fórmula: C₁₉H₂₁NO₄·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 327.38 36.46

Ref: 4Z-N-211

Naloxone Hydrochloride

CAS: 357-08-4

Fórmula: C₁₉H₂₁NO₄HCl

Peso molecular: 327.4 : 36.46

Ref: ST-EA-CP-N37001

Naloxone Hydrochloride

Produto Controlado

CAS: 357-08-4

Stability Hygroscopic
Applications Naloxone Hydrochloride is a specific opioid antagonist. Narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

Fórmula: C₁₉H₂₁NO₄·ClH

Cor e Forma: Neat

Peso molecular: 363.84

Ref: TR-N285000

Naloxone hydrochloride

Produto Controlado

CAS: 357-08-4

Naloxone hydrochloride is a competitive antagonist at mu-, delta- and kappa-opioid receptors. Naloxone binding to receptors blocks the effects of opioids such as morphine, heroin, or oxycodone. Naloxone has been shown to be effective in treating acute overdoses of these drugs and reversing the depression of respiratory function that accompanies opioid overdose. It is also used to alleviate withdrawal symptoms and in the treatment of neonatal abstinence syndrome (NAS). NAS is a condition that occurs when infants are exposed to addictive levels of opioids in utero and go through withdrawal after birth.

Fórmula: C₁₉H₂₁NO₄•HCl

Pureza: (%) Min. 95%

Cor e Forma: Powder

Peso molecular: 363.84 g/mol

Ref: 3D-FN26128