CAS 37558-16-0

forbol 12,13-dibutirato

Descrição:

forbol 12,13-dibutirato (PDBu) é um éster de fobol sintético derivado do composto natural fobol, que é obtido da resina da planta Euphorbia. É caracterizado por sua capacidade de atuar como um potente promotor tumoral e um ativador da proteína quinase C (PKC), tornando-se uma ferramenta valiosa na pesquisa do câncer e em estudos de sinalização celular. PDBu é um composto lipofílico, o que lhe permite penetrar facilmente nas membranas celulares e interagir com alvos celulares. Sua estrutura inclui dois grupos butirato esterificados ao esqueleto de fobol, aumentando sua atividade biológica em comparação com outros ésteres de fobol. PDBu é frequentemente utilizado em ambientes de laboratório para induzir diferenciação em vários tipos de células e para estudar os mecanismos de transdução de sinal. Além disso, demonstrou influenciar vários processos celulares, incluindo proliferação, apoptose e expressão gênica. Devido aos seus potentes efeitos biológicos, PDBu é manuseado com cuidado em ambientes de pesquisa, e seu uso está sujeito a diretrizes regulatórias.

Fórmula: C₂₈H₄₀O₈

InChI: InChI=1/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3

Chave InChI: InChIKey=BQJRUJTZSGYBEZ-YVQNUNKESA-N

SMILES: O(C(CCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCC)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Sinónimos:

• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
• 12,13-Di-O-butyrylphorbol
• 4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
• 4β-Phorbol 12,13-dibutyrate
• 9aH-Cyclopropa[3,4]benz[1,2-e]azulene, butanoic acid deriv.
• Butanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester
• Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-
• Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-alpha))-
• Nsc 622507
• Phorbol dibutyrate
• Phorbol 12,13-dibutyrate
• Phorbol-12,13-dibutyrate
• C03634
• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester
• (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-5-oxo-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulene-4aα,7bα,9β,9aα-tetrol 9,9a-dibutyrate
• Phorbol 12,13-Dibutyrate >99%
• Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem
• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutyrate
• PHORBOL 12,13-DIBUTYRATE, 4BETA
• Phorbol 12,13-dibutanoate
• hyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diy
• butanoicacid,1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymet
• lester,(1ar-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-al
• (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5-oxo-5H-cyclopropa[3,4]benz[1,2-e]azulene-9β,9aα-diol 9,9a-dibutyrate
• 9β,9aα-Bis(butyryloxy)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

Phorbol 12,13-Dibutyrate

CAS: 37558-16-0

Fórmula: C₂₈H₄₀O₈

Pureza: 98%

Peso molecular: 504.6124

Ref: IN-DA00BXZ4

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Fórmula: C₂₈H₄₀O₈

Pureza: ≥ 98.0%

Cor e Forma: White to pale yellow or yellow solid

Peso molecular: 504.61

Ref: 7W-GL3377

Phorbol 12,13-Dibutyrate

CAS: 37558-16-0

Phorbol 12,13-Dibutyrate

Fórmula: C₂₈H₄₀O₈

Pureza: >99%

Cor e Forma: solid

Peso molecular: 504.61239g/mol

Ref: 54-BIP1016

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.

Fórmula: C₂₈H₄₀O₈

Pureza: 99.32% - 99.37%

Cor e Forma: Solid

Peso molecular: 504.61

Ref: TM-T16526

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Phorbol 12,13-dibutyrate is a potent inducer of protein kinase C (PKC) and is used as a tool to study PKC activity. It has been shown to induce the phosphorylation of certain proteins in human cells. This compound also induces the release of inflammatory mediators from polymorphonuclear leucocytes, which are white blood cells. Phorbol 12,13-dibutyrate is also used as a model system for studying the human papillary muscle and its biochemical properties. The effects of phorbol 12,13-dibutyrate on hl-60 cells have been studied extensively. This compound inhibits protein synthesis by preventing the binding of aminoacyl-tRNA to the ribosome and by inhibiting translocation of mRNA into the cytoplasm.

Fórmula: C₂₈H₄₀O₈

Pureza: Min. 95 Area-%

Cor e Forma: Powder

Peso molecular: 504.61 g/mol

Ref: 3D-MBA55816