CAS 37784-17-1

N-Boc-D-prolina

Descrição:

N-Boc-D-prolina, com o número CAS 37784-17-1, é um derivado do aminoácido prolina, caracterizado pela presença de um grupo protetor tert-butyloxycarbonyl (Boc) no átomo de nitrogênio. Essa modificação melhora sua estabilidade e solubilidade, tornando-o um intermediário valioso na síntese de peptídeos e na química orgânica. N-Boc-D-prolina é tipicamente um sólido cristalino branco a off-white, e é solúvel em solventes orgânicos comuns, como diclorometano e dimetilformamida, mas menos solúvel em água. O grupo Boc serve como um moiety protetor que pode ser removido em condições ácidas, permitindo a deproteção seletiva do grupo amino quando necessário. Este composto é frequentemente utilizado na síntese de peptídeos e outras moléculas bioativas, devido à sua capacidade de facilitar a formação de ligações peptídicas enquanto mantém a quiralidade do resíduo D-prolina. Suas características estruturais e reatividade fazem dele um bloco de construção importante na química medicinal e no desenvolvimento de medicamentos.

Fórmula: C₁₀H₁₆NO₄

InChI: InChI=1/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/p-1/t7-/m1/s1

SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)[O-]

Sinónimos:

• (2R)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylate
• 1-Boc-D-proline
• Boc-D-Pro-OH
• Boc-D-proline

N-(tert-Butoxycarbonyl)-D-proline

CAS: 37784-17-1

Fórmula: C₁₀H₁₇NO₄

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 215.25

Ref: 3B-B2977

N-Boc-D-proline, 98+%

CAS: 37784-17-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₁₀H₁₇NO₄

Pureza: 98+%

Cor e Forma: White, Crystals or powder or crystalline powder

Peso molecular: 215.25

Ref: 02-L08826

Boc-D-Pro-OH

CAS: 37784-17-1

Bachem ID: 4000664.

Fórmula: C₁₀H₁₇NO₄

Pureza: > 99.5%

Cor e Forma: White

Peso molecular: 215.25

Ref: 01-4000664

N-Boc-D-proline

CAS: 37784-17-1

Fórmula: C₁₀H₁₇NO₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 215.2463

Ref: IN-DA0035CW

N-Boc-D-proline

CAS: 37784-17-1

N-Boc-D-proline

Pureza: 98%

Cor e Forma: White Powder

Peso molecular: 215.25g/mol

Ref: 54-OR307074

N-Boc-D-proline

CAS: 37784-17-1

Fórmula: C₁₀H₁₇NO₄

Pureza: ≥ 98.0%

Cor e Forma: White powder or crystals

Peso molecular: 215.25

Ref: 7W-GM9500

Boc-D-Pro-OH

CAS: 37784-17-1

M03316 - Boc-D-Pro-OH

Fórmula: C₁₀H₁₇NO₄

Pureza: 97%

Cor e Forma: Solid, Crystalline Powder or Powder

Peso molecular: 215.249

Ref: 10-M03316

N-Boc-D-proline

CAS: 37784-17-1

Fórmula: C₁₀H₁₇NO₄

Peso molecular: 215.25

Ref: 4Z-P-166060

tert-Butoxycarbonyl-D-proline

Produto Controlado

CAS: 37784-17-1

Applications tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
References Jung, M., et al.: Bioorg. Med. Chem. Lett., 7, 1655 (1997); Lee, D., et al.: J. Med. Chem,, 44, 2015 (2001)

Fórmula: C₁₀H₁₇NO₄

Cor e Forma: Neat

Peso molecular: 215.25

Ref: TR-B692535

N-Boc-D-proline

CAS: 37784-17-1

N-Boc-D-proline is a lipase inhibitor that is used in the preparation of quinine, aldehyde, and carboxylate. N-Boc-D-proline has been shown to inhibit the activity of the sodium channels, which may be due to its ability to bind to the termini of these channels. The inhibition of sodium channels can lead to a decrease in nerve excitability and seizures. N-Boc-D-proline was synthesized by an organocatalytic method using sodium bicarbonate as the catalyst. It was found that this compound was stereoselective with respect to its activity on different enantiomers of chiral substrates. Preparative methods for N-Boc-D-proline include column chromatography or crystallization with diethyl ether or ethyl acetate. The isolated yield is about 99%.

Fórmula: C₁₀H₁₇NO₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 215.25 g/mol

Ref: 3D-FB11371

Boc-D-Pro-OH

CAS: 37784-17-1

Boc-D-Pro-OH is a model compound for the synthesis of peptides. Boc-D-Pro-OH has been used in many surface-enhanced Raman spectroscopy studies to investigate the stereochemistry of glycosidic bonds. It has also been used in pharmacokinetic studies to investigate the drug's absorption, distribution, metabolism, and excretion (ADME) properties. The solute is soluble in water due to its hydrophilic nature. Boc-D-Pro-OH is an enantiomer of Boc-L-Pro-OH and a functional group that contains a trifluoromethyl group. This chemical can be used in Tools for Peptide Synthesis with other compounds to form peptides with specific amino acid sequences.

Fórmula: C₁₀H₁₇NO₄

Pureza: Min. 95%

Peso molecular: 215.25 g/mol

Ref: 3D-BDP-2610

BOC-D-Proline extrapure, 99%

CAS: 37784-17-1

Fórmula: C₁₀H₁₇NO₄

Pureza: min. 99%

Cor e Forma: White, Crystalline compound

Peso molecular: 215.30

Ref: SR-93481