CAS 38048-32-7

S-(4-Nitrobenzil)-6-tioinosina

Descrição:

S-(4-Nitrobenzil)-6-tioinosina é um composto químico que pertence à classe dos análogos de nucleosídeos, especificamente purinas modificadas. Apresenta uma estrutura de tioinosina, onde o átomo de enxofre substitui o oxigênio no açúcar ribose, aumentando sua atividade biológica. A presença do grupo 4-nitrobenzila contribui para suas propriedades únicas, potencialmente influenciando sua interação com alvos biológicos. Este composto é frequentemente estudado por seu papel na pesquisa bioquímica, particularmente no contexto do metabolismo de nucleosídeos e suas potenciais aplicações terapêuticas. Pode exibir várias atividades biológicas, incluindo propriedades antivirais ou anticancerígenas, devido às suas modificações estruturais. O número CAS 38048-32-7 identifica de forma única essa substância em bancos de dados químicos, facilitando seu estudo e aplicação na pesquisa científica. Assim como muitos análogos de nucleosídeos, sua solubilidade, estabilidade e reatividade podem variar, tornando essencial considerar esses fatores em projetos experimentais. No geral, S-(4-Nitrobenzil)-6-tioinosina representa um composto significativo no campo da química medicinal e bioquímica.

Fórmula: C₁₇H₁₇N₅O₆S

InChI: InChI=1/C17H17N5O6S/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2/t11-,13-,14-,17-/m1/s1

Chave InChI: InChIKey=DYCJFJRCWPVDHY-LSCFUAHRSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(SCC4=CC=C(N(=O)=O)C=C4)N=CN3)O[C@H](CO)[C@H]1O

Sinónimos:

• 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
• 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
• S-(p-Nitrobenzyl)-6-mercapto-9-β-D-ribofuranosylpurine
• Inosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-
• S-(4-Nitrobenzyl)-6-thioinosine
• NSC 296962
• S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR)
• 6-(p-nitrobenzylthio)inosine
• 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
• 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin
• 6-[(4-Nitrobenzyl)-mercapto]-inosine
• S-(p-Nitrobenzyl)-6-mercapto-9--D-ribofuranosylpurine
• 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine
• 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosyl-9H-purine
• S-(4-Nitrobenzyl)-6-thioinosine,99%
• 6-[[(4-Nitrophenyl)methyl]thio]-9-(β-D-ribofuranosyl)-9H-purine
• NBMPR, NBTI, 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
• nitrobenzylthioinosine
• S-(P-NITROBENZYL)-6-THIOINOSINE
• S-(4-NITROBENZYL)-6-THIOINOSINE (NBTI) P OTENT ADENOSINE UPTA
• NBTI
• 4-Nitrobenzyl-6-mercaptoinosine
• (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
• S-(P-NITROBENZYL)-6-THIOINOSINE 98+%
• NBMPR

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

CAS: 38048-32-7

Fórmula: C₁₇H₁₇N₅O₆S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 419.4118

Ref: IN-DA003U66

Nitrobenzylthioinosine

CAS: 38048-32-7

Nitrobenzylthioinosine

Pureza: ≥98%

Peso molecular: 419.41g/mol

Ref: 54-BUP11914

6-[(4-Nitrobenzyl)Thio]-9-β-D-Ribofuranosylpurine

CAS: 38048-32-7

6-[(4-Nitrobenzyl)Thio]-9-β-D-Ribofuranosylpurine

Pureza: 98%

Peso molecular: 419.41g/mol

Ref: 54-OR1023078

S-(4-Nitrobenzyl)-6-thioinosine

CAS: 38048-32-7

Fórmula: C₁₇H₁₇N₅O₆S

Peso molecular: 419.41

Ref: 7W-GN6805

Nitrobenzylthioinosine

CAS: 38048-32-7

Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.

Fórmula: C₁₇H₁₇N₅O₆S

Pureza: 99.69% - 99.74%

Cor e Forma: Off-White Solid

Peso molecular: 419.41

Ref: TM-T8551

6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

CAS: 38048-32-7

Pureza: 98.0%

Peso molecular: 419.4100036621094

Ref: 10-F547423

S-(4-Nitrobenzyl)-6-thioinosine

CAS: 38048-32-7

S-(4-Nitrobenzyl)-6-thioinosine (SBT) is a nucleoside with biochemical properties that are similar to those of adenosine. SBT is an equilibrative nucleoside, which means that it can bind to both DNA and RNA. It has been shown to be effective in inhibiting the growth of cancer cells in vitro by binding to DNA. SBT binds to the purine nucleotide transporter and prevents the uptake of uridine, adenosine, and other nucleosides into the cell. This process leads to a decrease in intracellular concentrations of these nucleosides. SBT also binds to divalent metal ions such as copper or zinc, which may affect its activity on cancer cells.

Fórmula: C₁₇H₁₇N₅O₆S

Pureza: Min. 98 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 419.41 g/mol

Ref: 3D-NN09410

S-(4-Nitrobenzyl)-6-thioinosine

Produto Controlado

CAS: 38048-32-7

Applications S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
References (1) Zhu, Z., et al.: J. Med. Chem., 46, 831 (2003) (2) Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (2005) (3) Barnes, K., et al.: Circ. Res., 99, 510 (2006)

Fórmula: C₁₇H₁₇N₅O₆S

Cor e Forma: Neat

Peso molecular: 419.41

Ref: TR-N493695