CAS 380843-81-2

Bosutinib Impurity 2 (N-Desmethyl Bosutinib)

CAS: 380843-81-2

Fórmula: C₂₅H₂₇Cl₂N₅O₃

Cor e Forma: Off-White Solid

Peso molecular: 516.42

Ref: 4Z-B-646

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile

Produto Controlado

CAS: 380843-81-2

Applications Proteolysis Targeting Chimera (PROTAC) is a novel approach to modern drug development programs that utilizes small compounds to target proteins for ubiquitination and degradation by proteasome. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile is a PROTAC compound, which has the potential to target oncogenic BCR-ABL for degradation. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile has also been employed in ligand-based pharmacophore modelling to identify c-Src inhibitors.
References Lai, A. C., et al., Angew. Chem. Int. Ed. 55, 807 (2016); Sakkiah, S., et al., J. Enzyme Inhib. Med. Chem. 29, 69 (2014)

Fórmula: C₂₅H₂₇Cl₂N₅O₃

Cor e Forma: Light Brown

Peso molecular: 516.42

Ref: TR-D435305

N-Desmethyl Bosutinib

CAS: 380843-81-2

Fórmula: C₂₅H₂₇Cl₂N₅O₃

Peso molecular: 516.4

Ref: ST-EA-CP-B80012

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile

CAS: 380843-81-2

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Fórmula: C₂₅H₂₇Cl₂N₅O₃

Pureza: Min. 95%

Peso molecular: 516.4 g/mol

Ref: 3D-FQA84381