CAS 38176-02-2

(+)-[3-ciano-3-(3,4-dimetoxifenil)hex-6-il](5,6-dimetoxifenetil)metilamônio cloreto

Descrição:

A substância química conhecida como "(+)-[3-ciano-3-(3,4-dimetoxifenil)hex-6-il](5,6-dimetoxifenetil)metilamônio cloreto" com o número CAS 38176-02-2 é um composto de amônio quaternário caracterizado por sua estrutura complexa, que inclui um grupo ciano, múltiplos substituintes metóxi e uma cadeia hexílica. Este composto exibe propriedades típicas de sais de amônio quaternário, como solubilidade em solventes polares e potencial atividade biológica. A presença de grupos metóxi sugere que pode ter uma lipofilicidade aumentada, o que pode influenciar sua interação com membranas biológicas. Além disso, o grupo ciano pode conferir características únicas de reatividade e estabilidade. Como sal de cloreto, é provável que seja iônico por natureza, contribuindo para sua solubilidade em ambientes aquosos. A estereoquímica específica indicada pela designação "(+)" sugere que pode exibir propriedades quirais, o que pode afetar seu perfil farmacológico e interações em sistemas biológicos. No geral, as características estruturais únicas deste composto podem torná-lo de interesse na química medicinal e farmacologia.

Fórmula: C₂₇H₃₈N₂O₄·ClH

InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m1./s1

Chave InChI: InChIKey=DOQPXTMNIUCOSY-HZPIKELBSA-N

SMILES: [C@](CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

Sinónimos:

• (+)-Verapamil hydrochloride
• (2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride (1:1)
• (R)-Verapamil hydrochloride
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1), (αR)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (R)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (αR)-
• Dexverapamil monohydrochloride
• Lu 33925
• NSC 632821
• (+)-(3-Cyano-3-(3,4-dimethoxyphenyl)hex-6-yl)(5,6-dimethoxyphenethyl)methylammonium chloride
• R(+)-Verapamil hydrate monohydrochloride
• Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI)
• R(+)-Verapamil monohydrochloride
• (+)-[3-cyano-3-(3,4-diMethoxyphenyl)hex-6-yl](5,6-
• (αR)-α-[3-[[2-(3,4-DiMethoxyphenyl)ethyl]MethylaMino]propyl]-3,4-diMethoxy-α-(1-Methylethyl)-benzeneacetonitrile Hydrochloride
• R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
• Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)-
• R(+)-Verapamil monohydrochloride hydrate

(R)-Verapamil (hydrochloride)

CAS: 38176-02-2

(R)-Verapamil (hydrochloride)

Pureza: 98%

Peso molecular: 491.06g/mol

Ref: 54-OR1034236

R-Verapamil HCl

CAS: 38176-02-2

Fórmula: C₂₇H₃₈N₂O₄·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 454.61 36.46

Ref: 4Z-V-046

R-(+)-Verapamil monohydrochloride hydrate

CAS: 38176-02-2

Fórmula: C₂₇H₄₁ClN₂O₅

Peso molecular: 509.08

Ref: 7W-GP6309

(R)-(+)-Verapamil Hydrochloride

Produto Controlado

CAS: 38176-02-2

Applications (R)-(+)-Verapamil Hydrochloride and both of its isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988); Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990);

Fórmula: C₂₇H₃₈N₂O₄·ClH

Cor e Forma: Neat

Peso molecular: 491.06

Ref: TR-V124990

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride

CAS: 38176-02-2

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride (ZD4054) is a drug that has been shown to be sensitive to the efflux pump in Escherichia coli. It is also able to inhibit multidrug resistance in nematodes and cross-resistance in humans. ZD4054 inhibits multidrug resistance by inhibiting the efflux of drugs from cells. This prevents the development of resistance to antibiotics and other drugs. The mechanism of action for this drug is unknown, but it may affect chloride channels that are found on the cell membrane. ZD4054 has also been shown to be effective against C.elegans and Drosophila melanogaster, two species commonly used for research purposes.

Fórmula: C₂₇H₃₉ClN₂O₄

Pureza: Min. 95%

Peso molecular: 491.06 g/mol

Ref: 3D-ID28684

(R)-Verapamil hydrochloride

CAS: 38176-02-2

(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.

Fórmula: C₂₇H₃₉ClN₂O₄

Cor e Forma: Solid

Peso molecular: 491.06

Ref: TM-T12646