CAS 388082-77-7

ditosilato de lapatinibe

Descrição:

ditosilato de lapatinibe é um inibidor de tirosina quinase de pequenas moléculas usado principalmente no tratamento de certos tipos de câncer de mama, particularmente aqueles que são positivos para HER2. Funciona inibindo a atividade do receptor do fator de crescimento epidérmico (EGFR) e HER2, que estão envolvidos na proliferação e sobrevivência das células cancerosas. O composto é caracterizado por sua fórmula molecular, que reflete sua estrutura complexa, incluindo um grupo dicloroanilina e um grupo sulfonato que melhora sua solubilidade. ditosilato de lapatinibe é tipicamente administrado por via oral e é conhecido por sua capacidade de penetrar a barreira hematoencefálica, tornando-se uma opção potencial para o tratamento de metástases cerebrais. Sua farmacocinética inclui absorção moderada e uma meia-vida que permite a dosagem uma vez ao dia. Efeitos colaterais comuns podem incluir diarreia, erupção cutânea e náuseas. Assim como em qualquer terapia direcionada, seu uso é frequentemente acompanhado de monitoramento da eficácia e reações adversas, enfatizando a importância da medicina personalizada em oncologia.

Fórmula: C₄₃H₄₂ClFN₄O₁₀S₃

InChI: InChI=1/C29H26ClFN4O4S.2C6H6O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*7-10(8,9)6-4-2-1-3-5-6;/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*1-5H,(H,7,8,9);1H2

Chave InChI: InChIKey=OZDXXJABMOYNGY-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4.S(=O)(=O)(O)C1=CC=C(C)C=C1

Sinónimos:

• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate (1:2)
• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, bis(4-methylbenzenesulfonate)
• Benzenesulfonic Acid
• Gw 572016F
• Hydrate
• Lapatinib Ditoyslate
• Lapatinib ditosylate anhydrous
• Lapatinib, Tykerb, GW572016
• N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate)
• N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine h ydrate
• N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
• N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine benzenesulfonate hydrate (1:2:1)
• N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulfonate)
• Tykerb
• Tykerb N-{3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl}-6-{5-{(2-methylsulfonylethy amino)-methyl]-2-furyl}-quinazolin-4-amine-benzenesulfonic acid
• Lapatinib ditosylate
• GW-572016 ditosylate
• Lapatinib (GW-572016) Ditosylate
• GW 572016 ditosylate
• N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylBenzenesulfonate)
• Lapatinib Ditosylate (Tykerb)
• N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(Methylsulfonyl)ethyl]aMino}Methyl)-2-furyl]-4-quinazolinaMine 4-Methylbenzenesulfonate (1:2)
• GW-572016F Ditosylate
• Tykerb Ditosylat
• Lapatinib ditasylate
• N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate
• Tykerb(lapatinib)
• Tykerb Ditosylate

Lapatinib Ditosylate

CAS: 388082-77-7

Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).

Fórmula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Pureza: 99.41%

Cor e Forma: Yellow Solid

Peso molecular: 925.46

Ref: TM-T6235

Lapatinib ditosylate

CAS: 388082-77-7

Fórmula: C₄₃H₄₂ClFN₄O₁₀S₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 925.4608

Ref: IN-DA00C6B6

Lapatinib Ditosylate

CAS: 388082-77-7

Lapatinib Ditosylate

Pureza: ≥98%

Peso molecular: 925.46g/mol

Ref: 54-BUP15047

Lapatinib Ditosylate

CAS: 388082-77-7

Fórmula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Cor e Forma: Yellow Solid

Peso molecular: 581.06 2*172.20

Ref: 4Z-L-255

Lapatinib-d4 Ditosylate

CAS: 388082-77-7

Fórmula: C₂₉H₂₂D₄ClFN₄O₄S·2C₇H₈O₃S

Cor e Forma: Light Yellow Solid

Peso molecular: 585.08 2 172.20

Ref: 4Z-L-253

N-(3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)-6-(5-(((2-(Methylsulfonyl)Ethyl)Amino)Methyl)Furan-2-Yl)Quinazolin-4-Amine Bis(4-Methylbenzenesulfonate)

CAS: 388082-77-7

N-(3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)-6-(5-(((2-(Methylsulfonyl)Ethyl)Amino)Methyl)Furan-2-Yl)Quinazolin-4-Amine Bis(4-Methylbenzenesulfonate)

Pureza: 98%

Peso molecular: 925.46g/mol

Ref: 54-PC109179

Lapatinib Ditosylate

CAS: 388082-77-7

Fórmula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 925.46

Ref: 3B-L0467

Lapatinib Ditosylate

Produto Controlado

CAS: 388082-77-7

Applications Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.
References Kim, T.E., et al.: Drugs, 6, 886 (2003), Wood, E.R., et al.: Cancer Res., 64, 6652 (2004), Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),

Fórmula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Cor e Forma: Yellow

Peso molecular: 925.46

Ref: TR-L175800

Lapatinib tosylate anhydrous

CAS: 388082-77-7

Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.

Fórmula: C₂₉H₂₆ClFN₄O₄S•(C₇H₈O₃S)₂

Pureza: Min. 95%

Cor e Forma: Off-White Powder

Peso molecular: 925.46 g/mol

Ref: 3D-FL65053