CAS 4004-05-1

1,2-Dioleoil-sn-glicero-3-fosfoetanolamina

Descrição:

1,2-Dioleoil-sn-glicero-3-fosfoetanolamina (DOPE) é um fosfolípido comumente utilizado em bioquímica e biologia molecular. É caracterizado por suas cadeias de ácidos graxos oleoyl duais, que contribuem para sua natureza anfifílica, permitindo-lhe formar bicamadas lipídicas e vesículas em ambientes aquosos. A molécula consiste em uma espinha dorsal de glicerol, duas cadeias oleoyl e um grupo cabeça de fosfoetanolamina, que confere uma carga líquida neutra a pH fisiológico. O DOPE é conhecido por sua capacidade de facilitar a fusão de membranas e é frequentemente utilizado em sistemas de entrega de medicamentos, particularmente para a encapsulação de ácidos nucleicos e proteínas. Sua fluidez e capacidade de adotar várias conformações fazem dele um componente valioso em formulações lipossomais. Além disso, o DOPE pode melhorar a estabilidade e eficácia de vacinas e terapias gênicas. A substância é tipicamente armazenada em condições controladas para manter sua integridade e é solúvel em solventes orgânicos, tornando-a adequada para várias aplicações de laboratório.

Fórmula: C₄₁H₇₈NO₈P

InChI: InChI=1/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1

Chave InChI: InChIKey=MWRBNPKJOOWZPW-NYVOMTAGSA-N

SMILES: [C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCN)(=O)O

Sinónimos:

• (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-[(9Z)-octadec-9-enoyloxy]propyl (9Z)-octadec-9-enoate
• 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphorylethanolamine
• 9-Octadecenoic acid (9Z)-, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 9-Octadecenoic acid (9Z)-, 1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• 9-Octadecenoic acid (Z)-, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-
• <span class="text-smallcaps">L</span>-α-Dioleoylphosphatidylethanolamine
• Coatsome MC 8181
• Coatsome ME 8181
• Dioleoyl phosphoethanolamine
• Dioleoyl-<span class="text-smallcaps">L</span>-α-phosphatidylethanolamine
• Dioleoylphosphatidylethanolamine
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, <span class="text-smallcaps">L</span>-
• L-A-phosphatidylethanolamine dioleoyl
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">L</span>-
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, L-
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, L-
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, >99%
• (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO-ETHA-N OLAMINE, 10 MG/ML
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)
• 1,2-Dioleoyl-sn-glycero-3-PE
• sn
• PE(18:1(9Z)/18:1(9Z))
• 18:1 PE
• 3-SN-PHOSPHATIDYLETHANOLAMINE, 1,2-DIDEOYL
• O-(1-O,2-O-Dioleoyl-L-glycero-3-phospho)-2-aminoethanol
• 18:1 (Delta9-Cis) PE (DOPE)
• 2-Aminoethyl (R)-2,3-bis(oleoyloxy)propyl hydrogen phosphate
• 1,2-Dioleoyl-
• dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)
• 1,2-Dioleoyl-3-sn-phosphatidylethanolamine
• L-β,γ-Dioleoyl-α-cephalin
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL (C18:1,[CIS]-9)
• DOPE
• L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN
• (+)-1-O,2-O-Dioleoyl-L-glycerol 3-(phosphoric acid 2-aminoethyl) ester
• Phosphoric acid hydrogen (2-aminoethyl)[(2R)-2,3-bis(oleoyloxy)propyl] ester
• L-A-PHOSPHATIDYLETHANOLAMINE, DIOLEO
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine≥ 98% (HPTLC)
• DIOLEOYL PHOSPHATIDYL ETHANOLAMINE
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 98+%
• 3-sn-Phosphatidylethanolamine, 1,2-dideoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE
• COATSOME ME-8181 (DOPE)
• -glycero-3-phosphoethanolamine

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

Fórmula: C₄₁H₇₈NO₈P

Pureza: >98.0%(T)

Cor e Forma: White to Light yellow powder to lump

Peso molecular: 744.05

Ref: 3B-D4251

9-Octadecenoic acid (9Z)-,(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediylester

CAS: 4004-05-1

Fórmula: C₄₁H₇₈NO₈P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 744.0337

Ref: IN-DA00IMFR

DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

Pureza: ≥95%

Peso molecular: 744.03g/mol

Ref: 54-BUP17310

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

CAS: 4004-05-1

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

Fórmula: C₄₁H₇₈NO₈P

Pureza: 98%

Peso molecular: 744.03g/mol

Ref: 54-BI12158

1,2-Dioleoyl-d62-sn-glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Fórmula: C41H16D62NO8P

Pureza: >98%

Cor e Forma: Solid

Peso molecular: 806.43

Ref: 48-71-5718

1,2-Dioleoyl-sn-Glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Fórmula: C41H78NO8P

Pureza: >98%

Cor e Forma: Solid

Peso molecular: 744.04

Ref: 48-37-1821

DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine)

CAS: 4004-05-1

Fórmula: C₄₁H₇₈NO₈P

Peso molecular: 744.05

Ref: 4Z-F-106056

DOPE

CAS: 4004-05-1

DOPE, a neutral lipid, boosts cationic liposome efficiency in non-viral gene delivery.

Fórmula: C₄₁H₇₈NO₈P

Pureza: 97.23% - ≥98%

Cor e Forma: Lyophilized Powder

Peso molecular: 744.03

Ref: TM-T19080

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE

Fórmula: C₄₁H₇₈NO₈P

Pureza: 98%

Cor e Forma: light yellow waxy solid

Peso molecular: 744.03368g/mol

Ref: 54-OR54392

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)

Produto Controlado

CAS: 4004-05-1

Applications 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
References Misra, S.K., et al.: PLoS One, 8, e68305 (2013); MacDonald, R., et al.: J. Pharm. Sci., 88, 896 (1999); Chen, Y., et al.: Int. J. Nanomedicine, 8, 1573 (2013)

Fórmula: C₄₁H₇₈NO₈P

Cor e Forma: Neat

Peso molecular: 744.034

Ref: TR-D482210

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a synthetic lipid that has been extensively studied for its ability to form liposomes and other lipid bilayers. DOPE is used as a model system for studying the phase transition temperature of phospholipid membranes. DOPE has also been shown to be effective in the transfection of cells with plasmids and other DNA molecules. DOPE is cationic, which allows it to interact with anionic membrane proteins and facilitate their insertion into the membrane. This facilitates the formation of multilamellar vesicles, which are necessary for vesicle budding and fusion.

Fórmula: C₄₁H₇₈NO₈P

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 744.03 g/mol

Ref: 3D-FD148481

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

M01678 - 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Fórmula: C₄₁H₇₈NO₈P

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 744.048

Ref: 10-M01678

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4

Produto Controlado

CAS: 4004-05-1

Fórmula: C₄₁D₄H₇₄NO₈P

Cor e Forma: Neat

Peso molecular: 748.058

Ref: TR-D482212