CAS 400827-64-7

ácido 7β-amino-3-[4-piridil-2-tiazol radical de enxofre]-3-cefem-4-carboxílico・2HCl

Descrição:

O 7β-amino-3-[4-piridil-2-tiazol radical de enxofre]-3-cefem-4-ácido carboxílico, com o número CAS 400827-64-7, é um composto sintético pertencente à classe de antibióticos cefêmicos, caracterizados por sua estrutura de β-lactama. Este composto apresenta um grupo tiazol e um anel de piridina, contribuindo para suas propriedades farmacológicas únicas. A presença do grupo amino na posição 7β aumenta sua atividade antibacteriana ao facilitar interações com as enzimas de síntese da parede celular bacteriana. O grupo ácido carboxílico na posição 4 é crucial para a solubilidade e bioatividade. Como sal de cloridrato (indicado pelo 2HCl), é provável que apresente melhor estabilidade e solubilidade em ambientes aquosos, tornando-o adequado para formulações farmacêuticas. A estrutura do composto sugere uma potencial eficácia contra uma variedade de bactérias Gram-positivas e Gram-negativas, embora a atividade específica dependa de estudos empíricos adicionais. No geral, este composto representa uma abordagem nova no desenvolvimento de antibióticos, particularmente no contexto de combater a resistência a antibióticos.

Fórmula: C₁₆H₁₆Cl₂N₄O₃S₃

InChI: InChI=1S/C16H14N4O3S3.2ClH/c1-19-4-2-8(3-5-19)9-6-25-16(18-9)26-10-7-24-14-11(17)13(21)20(14)12(10)15(22)23;;/h2-6,11,14H,7,17H2,1H3;2*1H/t11-,14-;;/m1../s1

Chave InChI: InChIKey=SCEMEDZWEIWQPU-WGSPLUPMSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](N)C2=O)(SCC1SC3=NC(=CS3)C=4C=C[N+](C)=CC4)[H].[Cl-].Cl

Sinónimos:

• Pyridinium, 4-[2-[[(6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-, chloride, monohydrochloride
• Pyridinium,4-[2-[[(6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-,chloride,hydrochloride(1:1:1)
• Pyridinium,4-[2-[[(6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-
• 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic aci
• 4-(2-(((6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicycL
• Ceftaroline mother core (dihydrochloride)
• 7β-amino-3-[4-pyridyl-2-thiazole-thio]-3-cephem-4-carboxylic acid dihydrochloride
• azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-
• Ceftaroline mainchain
• pyridin-1-ium chL
• o[4.2.0]oct-2-en-3-yL
• ,chloride, hydrochloride (1:1:1)
• 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid ·2HC
• eleven β- [4 - (n, N-dimethylamino) - phenyl] - 17 α- Hydroxy-19-norgestrol-4,9-diene-3,20-dione
• 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM
• 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid ·2HCl
• 4-[2-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-pyridinium chloride monohydrochloride
• 4-(2-(((6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)thio)thiazol-4-yl)-1-methylpyridin-1-ium chloride hydrochloride
• 7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-pyridinium chloride monohydrochloride

Pyridinium,4-[2-[[(6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-, chloride, monohydrochloride

CAS: 400827-64-7

Fórmula: C₁₆H₁₆Cl₂N₄O₃S₃

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 479.4242

Ref: IN-DA00CKNE

4-(2-(((6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)thio)thiazol-4-yl)-1-methylpyridin-1-ium chloride hydrochloride

CAS: 400827-64-7

4-(2-(((6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)thio)thiazol-4-yl)-1-methylpyridin-1-ium chloride hydrochloride

Pureza: 97%

Peso molecular: 479.44g/mol

Ref: 54-OR1068797

4-(2-(((6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)thio)thiazol-4-yl)-1-methylpyridin-1-ium chloride hydrochloride

CAS: 400827-64-7

Pureza: 97%

Peso molecular: 479.4100037

Ref: 10-F690798

4-[2-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-pyridinium Chloride Monoh ydrochloride

CAS: 400827-64-7

4-[2-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium Chloride Monohydrochloride is a drug product under development for the treatment of bacterial infections. 4-[2-[(6R,7R)-7Amino--2carboxy8oxo5thia1azabicyclo[4.2.0]oct2en3yl]thio]-4thiazolyl]-1methylpyridinium Chloride Monohydrochloride is an impurity in the API Methicillin (CAS No. 40082764). Impurities are not necessarily undesirable and may have substantial therapeutic value or provide a desired

Fórmula: C₁₆H₁₅N₄O₃S₃·Cl·HCl

Pureza: Min. 95%

Peso molecular: 479.43 g/mol

Ref: 3D-IA172859