CAS 402824-96-8

6-cloro-4-[[(6-cloro-1,1-dioxo-3,4-diidro-2H-benzo[e][1,2,4]tiazina-7-il)sulfonilamino]metil]-1,1-dioxo-2,3-diidrobenzo[e][1,2,4]tiazina-7-sulfonamida

Descrição:

6-cloro-4-[[(6-cloro-1,1-dioxo-3,4-diidro-2H-benzo[e][1,2,4]tiazina-7-il)sulfonilamino]metil]-1,1-dioxo-2,3-diidrobenzo[e][1,2,4]tiazina-7-sulfonamida, com número CAS 402824-96-8, é um composto orgânico complexo caracterizado por sua estrutura de múltiplos anéis e a presença de grupos funcionais sulfonamida e dioxo. Este composto apresenta um substituinte cloro, que contribui à sua reatividade e potencial atividade biológica. A presença de anéis de tiadiazina sugere aplicações potenciais em química medicinal, particularmente no desenvolvimento de fármacos. O grupo sulfonamida é conhecido por suas propriedades antibacterianas, indicando que este composto pode exibir atividades biológicas semelhantes. Sua estrutura intrincada também pode influenciar sua solubilidade, estabilidade e interação com alvos biológicos. No geral, este composto representa uma classe de compostos heterocíclicos que podem ter implicações significativas na descoberta e desenvolvimento de medicamentos, particularmente na orientação a enzimas ou receptores específicos em várias áreas terapêuticas. Estudos adicionais seriam necessários para elucidar seu comportamento químico completo e aplicações potenciais.

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

InChI: InChI=1/C15H16Cl2N6O8S4/c16-8-1-10-14(34(28,29)20-5-19-10)4-13(8)33(26,27)21-6-23-7-22-35(30,31)15-3-12(32(18,24)25)9(17)2-11(15)23/h1-4,19-22H,5-7H2,(H2,18,24,25)

SMILES: c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)NCN1CNS(=O)(=O)c2cc(c(cc12)Cl)S(=O)(=O)N)Cl

Sinónimos:

• Hydrochlorothiazide EP Impurity C (Hydrochlorothiazide Dimer)
• Hydrochlorothiazide EP impurity C/ Dimer
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode
• 6
• ,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
• Hydrochlorothiazide Impurity C
• 6-chloro-4-((6-chloro-1,1-dioxido-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamido)methyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
• Hydrochlorothiazide IMpurity-C(EP)
• Hydrochlorothiazide Dimer
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ
• HCTZ-CH2-HCTZ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide\nHydrochlorothiazide Impurity C:
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamid
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, N-[[7-(aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-, 1,1-dioxide
• 6-Chloro-N-[(6-chloro-7-sulfamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• ,2,4-benzothiadiazine-7-sulfonamide

Hydrochlorothiazide Dimer (6-Chloro-4-({[(6-chloro-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl)sulfonyl]amino}methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide)

CAS: 402824-96-8

Sulfonamides, nesoi

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Cor e Forma: White Solid

Peso molecular: 605.92895

Ref: 45-1A15670

N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode

CAS: 402824-96-8

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 607.4889

Ref: IN-DA00C9HM

Hydrochlorothiazide EP Impurity C

CAS: 402824-96-8

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Cor e Forma: White To Off-White Solid

Peso molecular: 607.47

Ref: 4Z-H-054

HCTZ-CH2-HCTZ

CAS: 402824-96-8

HCTZ-CH2-HCTZ

Pureza: 98%

Ref: 54-OR1037135

Hydrochlorothiazide Impurity C

CAS: 402824-96-8

Impurity C in hydrochlorothiazide, a thiazide diuretic blocking NaCl cotransporter in kidneys.

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Cor e Forma: Solid

Peso molecular: 607.49

Ref: TM-T35728

6-Chloro-N-[(6-chloro-7-sulphamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-Dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothia-diazine-7-sulphonamide 1,1-Dioxide

CAS: 402824-96-8

Cor e Forma: Neat

Ref: 86-MM0011.04

Hydrochlorothiazide Dimer

CAS: 402824-96-8

Impurity Hydrochlorothiazide EP Impurity C
Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C.
References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Cor e Forma: Off-White

Peso molecular: 607.49

Ref: TR-A629375

Hydrochlorothiazide EP impurity C

CAS: 402824-96-8

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Peso molecular: 607.47

Ref: ST-EA-CP-H3003

Hydrochlorothiazide impurity C

CAS: 402824-96-8

Hydrochlorothiazide is a sulfonamide that inhibits the activity of the enzyme, angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to the potent vasoconstrictor, angiotensin II. It also has antihypertensive effects by blocking the production of aldosterone, which causes sodium retention and leads to high blood pressure. It is a byproduct in reactions with substances such as valsartan. Hydrochlorothiazide may react chemically with other medicines such as ampicillin and cefaclor.

Fórmula: C₁₅H₁₆Cl₂N₆O₈S₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 607.49 g/mol

Ref: 3D-IA17850