CAS 4033-27-6

ácido diidrofolato

Descrição:

ácido diidrofolato, também conhecido como 7,8-dihidrofolato, é um derivado da vitamina B solúvel em água que desempenha um papel crucial na síntese de ácidos nucleicos e aminoácidos. É um intermediário chave na via metabólica do folato, que é essencial para a divisão e crescimento celular. ácido diidrofolato é caracterizado por sua estrutura, que inclui um anel de pteridina, ácido para-aminobenzoico e resíduos de ácido glutâmico. Este composto é tipicamente encontrado no corpo como resultado da redução do ácido fólico, facilitada pela enzima diidrofolato redutase. Está envolvido na conversão do folato dietético em suas formas ativas, que são necessárias para a síntese e reparo do DNA. ácido diidrofolato também é significativo na farmacologia, pois certos antibióticos, como sulfonamidas, inibem sua síntese em bactérias, exercendo assim seus efeitos antimicrobianos. Seu número CAS, 4033-27-6, é usado para identificação em bancos de dados químicos e contextos regulatórios. No geral, ácido diidrofolato é vital para manter funções celulares adequadas e a saúde geral.

Fórmula: C₁₉H₂₁N₇O₆

InChI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1

Chave InChI: InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N

SMILES: O=C1C2=C(NCC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)NC(N)=N1

Sinónimos:

• 7,8-Dihydro-<span class="text-smallcaps">L</span>-folic acid
• 7,8-Dihydrofolic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Dihydrofolate
• Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• L-Glutamic acid, N-(4-(((2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- (9CI)
• N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• Nsc 165989
• L-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Dihydrofolic acid
• Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
• N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• 7,8-Dihydropteroyl-L-glutaMic acid
• (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
• Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid
• Folinic Acid Impurity G (7,8-Dihydrofolic Acid)
• 7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2
• Levofolinate EP Impurity G
• Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)
• 2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
• N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid
• Impurity G of Calcium Levofolinate
• Folic Acid 7,8-Dihydro Impurity
• FAH2
• 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID
• DIHYDROPTEROYL-L-GLUTAMIC ACID
• Folinic Acid EP Impurity G

Dihydrofolic acid

CAS: 4033-27-6

Fórmula: C₁₉H₂₁N₇O₆

Pureza: 90%

Cor e Forma: Solid

Peso molecular: 443.4133

Ref: IN-DA003PJ0

(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

CAS: 4033-27-6

(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

Pureza: 90%

Peso molecular: 443.42g/mol

Ref: 54-OR1074661

Dihydrofolic acid

CAS: 4033-27-6

Fórmula: C₁₉H₂₁N₇O₆

Pureza: ≥ 90.0%

Cor e Forma: Off-white to beige or grey solid

Peso molecular: 443.41

Ref: 7W-GV4745

Dihydrofolic acid

CAS: 4033-27-6

Dihydrofolic acid (7,8-Dihydrofolic acid) is a folic acid derivative that produces tetrahydrofolic acid in the presence of dihydrofolic acid reductase.

Fórmula: C₁₉H₂₁N₇O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 443.41

Ref: TM-T15128

Dihydro Folic Acid

CAS: 4033-27-6

Stability Hygroscoipic, Light and Air Sensitive
Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),

Fórmula: C₁₉H₂₁N₇O₆

Cor e Forma: Light Beige To Grey

Peso molecular: 443.41

Ref: TR-D449700

Levofolinate EP Impurity G

CAS: 4033-27-6

Fórmula: C₁₉H₂₁N₇O₆

Peso molecular: 443.4

Ref: ST-EA-CP-L57007

Dihydrofolic acid

CAS: 4033-27-6

Dihydrofolic acid is an organic compound that is a derivative of folic acid. It is the reduced form of folic acid and can be used to treat certain autoimmune diseases, such as bowel disease. Dihydrofolic acid has been shown to have antimicrobial effects against infectious diseases, including tuberculosis. This compound can also be used to treat metal-chelate resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Dihydrofolic acid has been shown to have neuroprotective properties in animals models and may be a potential drug target for the treatment of Alzheimer's disease.

Fórmula: C₁₉H₂₁N₇O₆

Pureza: (%) Min. 90%

Cor e Forma: Powder

Peso molecular: 443.41 g/mol

Ref: 3D-FD170209

Dihydro Folic Acid-D4 (Technical Grade)

Produto Controlado

CAS: 4033-27-6

Fórmula: C₁₉D₄H₁₇N₇O₆

Cor e Forma: Neat

Peso molecular: 447.438

Ref: TR-D449702

7,8-Dihydrofolic Acid ((4-(((2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid)

CAS: 4033-27-6

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₁₉H₂₁N₇O₆

Cor e Forma: Brown Solid

Peso molecular: 443.15533

Ref: 45-1A06330