CAS 40505-27-9

4′-Desmetilpodofilotoxina

Descrição:

4′-Desmetilpodofilotoxina é um composto químico derivado da espécie vegetal Podophyllum peltatum, comumente conhecido como mayapple. É classificado como um lignano, que é um tipo de composto polifenólico. Esta substância é caracterizada por suas características estruturais, incluindo um esqueleto de dibenzilbutirolactona, que contribui à sua atividade biológica. 4′-Desmetilpodofilotoxina exibe propriedades antitumorais e tem sido estudado por seu potencial uso na terapia do câncer, particularmente devido à sua capacidade de inibir a divisão celular ao interferir com o fuso mitótico. O composto também é conhecido por seu papel como precursor na síntese de outros derivados farmacologicamente ativos. Em termos de solubilidade, geralmente é mais solúvel em solventes orgânicos do que em água, o que pode influenciar sua biodisponibilidade e aplicações terapêuticas. Assim como muitos produtos naturais, os processos de extração e purificação podem afetar seu rendimento e potência, tornando-se uma área de interesse para mais pesquisas em química medicinal e farmacologia.

Fórmula: C₂₁H₂₀O₈

InChI: InChI=1/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19-/m0/s1

Chave InChI: InChIKey=YVCVYCSAAZQOJI-BTINSWFASA-N

SMILES: O=C1[C@@]2([C@@H](C=3C([C@H](O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H]

Sinónimos:

• (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• (5R,5aR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
• 4′-O-Demethylpodophyllotoxin
• 9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-(5α,5aβ,8aα,9α)]-
• Podophyllotoxin, 4′-demethyl-
• 4′-Demethylpodophyllotoxin
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
• (5R,5AR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
• 4'-Demethylpodophyllotoxin USP/EP/BP
• (5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-9β-hydroxy-5,5aα,6,8,8aβ,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6-one
• (5R)-5,8,8aβ,9-Tetrahydro-5β-(3,5-dimethoxy-4-hydroxyphenyl)-9β-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(5aαH)-one
• 5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one
• (5R)-5,8,8aβ,9-Tetrahydro-9β-hydroxy-5β-(3,5-dimethoxy-4-hydroxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one

Etoposide EP Impurity L

CAS: 40505-27-9

Fórmula: C₂₁H₂₀O₈

Peso molecular: 400.38

Ref: 4Z-E-598

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

4'-Demethylpodophyllotoxin

Pureza: ≥98%

Peso molecular: 400.38g/mol

Ref: 54-BUP06286

(5R,5aR,8aR,9R)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

CAS: 40505-27-9

Pureza: 97.0%

Peso molecular: 400.38299560546875

Ref: 10-F545202

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

Fórmula: C₂₁H₂₀O₈

Pureza: 95%~99%

Peso molecular: 400.383

Ref: BP-BP0076

Podophyllotoxin Impurity 1

CAS: 40505-27-9

Fórmula: C₂₁H₂₀O₈

Peso molecular: 400.38

Ref: 4Z-P-122001

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.

Fórmula: C₂₁H₂₀O₈

Pureza: 99.27% - 99.60%

Cor e Forma: Solid

Peso molecular: 400.38

Ref: TM-T2S0029

Etoposide EP Impurity L

CAS: 40505-27-9

Fórmula: C₂₁H₂₀O₈

Peso molecular: 400.4

Ref: ST-EA-CP-E31011

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

4'-Demethylpodophyllotoxin is a lignan derivative, which is sourced primarily from the roots and rhizomes of the plant species Podophyllum. This compound is a refined version of podophyllotoxin, a well-known precursor in the synthesis of anticancer drugs. The primary mode of action of 4'-Demethylpodophyllotoxin involves the inhibition of microtubule assembly, thereby disrupting the mitotic spindle formation essential for cell division. This mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cells, highlighting its potential in antitumor therapies.

Fórmula: C₂₁H₂₀O₈

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 400.38 g/mol

Ref: 3D-FD40476

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

Fórmula: C₂₁H₂₀O₈

Cor e Forma: Solid

Peso molecular: 400.3787

Ref: IN-DA003ARU

4’-Demethylpodophyllotoxin

Produto Controlado

CAS: 40505-27-9

Applications 4’-Demethylpodophyllotoxin is a lignan studied for its content in different parts of Sinopodophyllum hexandrum.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, Y-L., et al.: Zhongguo Zhongyao Zazhi, 40, 1837-1841 (2015)

Fórmula: C₂₁H₂₀O₈

Cor e Forma: Neat

Peso molecular: 400.38

Ref: TR-D231218