CAS 42228-92-2

Acivicina

Descrição:

Acivicina é um composto químico classificado como um potente inibidor da enzima glutamina sintetase, que desempenha um papel crucial no metabolismo do nitrogênio. É um análogo de aminoácido que ocorre naturalmente e é derivado de fontes microbianas. Acivicina exibe uma estrutura única que lhe permite imitar a glutamina, interferindo assim em suas funções metabólicas normais. Essa inibição pode levar a efeitos significativos nos processos celulares, tornando Acivicina de interesse na pesquisa do câncer e em potenciais aplicações terapêuticas. O composto foi estudado por sua capacidade de induzir apoptose em certas linhagens celulares cancerosas, destacando seu potencial como agente anticancerígeno. Além disso, Acivicina mostrou promessas na modulação de respostas imunológicas, expandindo ainda mais suas aplicações potenciais na medicina. No entanto, seu uso é limitado pela toxicidade e efeitos colaterais, exigindo uma consideração cuidadosa em contextos terapêuticos. No geral, Acivicina representa uma ferramenta valiosa na pesquisa bioquímica e no desenvolvimento de medicamentos, particularmente nos campos da oncologia e imunologia.

Fórmula: C₅H₇ClN₂O₃

InChI: InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1

Chave InChI: InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N

SMILES: [C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H]

Sinónimos:

• (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]ethanoic acid
• (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic acid
• (alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• (alphaS,5S)-alpha-Amino-3-chlor-4,5-dihydro-5-isoxazolylessigsaeure
• (alphaS,5S)-alpha-Amino-3-chloro-2-isoxazoline-5-acetic acid
• (α-S, 5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• 5-Isoxazoleacetic acid, 4,5-dihydro-alpha-amino-3-chloro-, (S-(R*,R*))-
• 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-
• 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-, (S-(R*,R*))-
• 5-Isoxazoleacetic acid, α-amino-3-chloro-4,5-dihydro-, (αS,5S)-
• 5-Isoxazoleacetic acid, α-amino-3-chloro-4,5-dihydro-, [S-(R*,R*)]-
• Acivicin [USAN:INN]
• Acivicine
• Acivicine [INN-French]
• Acivicino
• Acivicino [INN-Spanish]
• Acivicinum
• Acivicinum [INN-Latin]
• Amino(3-Chloro-4,5-Dihydro-1,2-Oxazol-5-Yl)Acetic Acid
• Antibiotic AT 125
• At 125
• Brn 1074648
• Nsc 163501
• U 42126
• Unii-O0X60K76I6
• Acivicin
• ALPHA-AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID
• (s-(r*,r*))-4,5-dihydro-alpha-amino-3-chloro-5-isoxazoleaceticacid
• (alpha-s,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleaceticacid
• (5S,αS)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
• antibioticat125
• AMINO-3-CHLORO-4,5-DIHYDROXY-5-ISOXAZOLEACETICACID
• (αS,5S)-
• Antibiotic U-42126
• (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid
• DIHYDROXY-5-ISOXAZOLEACETICACID
• 4,5-dihydro-alpha-amino-3-chloro-,(s-(r*,r*))-5-isoxazoleaceticaci
• AcivicinAcivicin

Acivicin, 98+%

CAS: 42228-92-2

Inhibits glutamine amidotransferases in purine and pyrimidine synthetic pathways. Tumor growth inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa A

Fórmula: C₅H₇ClN₂O₃

Pureza: 98+%

Cor e Forma: White to off-white, Powder

Peso molecular: 178.57

Ref: 02-J63105

ACIVICIN

CAS: 42228-92-2

Fórmula: C₅H₇ClN₂O₃

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 178.5737

Ref: IN-DA00C0CN

Acivicin

CAS: 42228-92-2

Acivicin

Pureza: 98%

Ref: 54-OR1037128

Acivicin

CAS: 42228-92-2

Acivicin (AT-125) is a chlorinated amino acid antibiotic produced by Streptomyces porcineus, a GGT inhibitor with anticancer and antiparasitic activity.

Fórmula: C₅H₇ClN₂O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 178.57

Ref: TM-T14114

Acivicin

Produto Controlado

CAS: 42228-92-2

Applications Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase (GGT). Acivicin is a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells.
References Hanigan, M., et al.: Biochemistry, 32, 6302 (1993); Suzuki, H., et al.: J. Bacteriol., 175, 6038 (1993); Suzuki, H., et al.: J. Biol. Chem., 277, 43536 (2002); Magdalena, L., et al.: Biochem. Pharma., 77, 76 (2009)

Fórmula: C₅H₇ClN₂O₃

Cor e Forma: Off White Solid

Peso molecular: 178.57

Ref: TR-A190150

Acivicin

CAS: 42228-92-2

Pureza: 98%

Peso molecular: 178.5700073

Ref: 10-F791463

(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid

CAS: 42228-92-2

(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid is an inhibitor of the enzyme glutathione reductase (GR) and cytochrome P450. GR activates glutathione in cells to form a powerful antioxidant that protects against oxidative stress. (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid inhibits GR and cytochrome P450 activity, leading to increased oxidative stress and neuronal death. This drug has been shown to have inhibitory properties on bowel disease by reducing the production of proinflammatory cytokines IL1β and TNFα. The compound also exhibits anti tumor response against mouse tumors by inducing apoptosis and inhibiting cell proliferation. The compound targets intracellular targets

Fórmula: C₅H₇ClN₂O₃

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 178.57 g/mol

Ref: 3D-FA17203