CAS 42267-27-6

N-trifluoroacetil-L-lisina N-carboxianidrido

Descrição:

N-trifluoroacetil-L-lisina N-carboxianidrido (CAS 42267-27-6) é um composto químico que pertence à classe dos N-carboxianidridos (NCA), que são intermediários importantes na síntese de polipeptídeos e proteínas. Este composto apresenta um grupo trifluoroacetil, que aumenta sua reatividade e solubilidade em solventes orgânicos. A presença do resíduo de lisina contribui para seu potencial de formar ligações peptídicas, tornando-o útil na química de polímeros e bioquímica. N-trifluoroacetil-L-lisina N-carboxianidrido é tipicamente caracterizado por sua estabilidade em condições anidras e sua capacidade de sofrer polimerização na presença de nucleófilos, como aminas ou álcoois. Sua modificação trifluoroacetil também pode influenciar as propriedades físicas dos polímeros resultantes, como hidrofobicidade e estabilidade térmica. No geral, este composto serve como uma ferramenta valiosa na síntese de peptídeos e polímeros funcionalizados, com aplicações em entrega de medicamentos, biomateriais e outros campos da ciência dos materiais.

Fórmula: C₉H₁₁F₃N₂O₄

InChI: InChI=1/C9H11F3N2O4/c10-9(11,12)7(16)13-4-2-1-3-5-6(15)18-8(17)14-5/h5H,1-4H2,(H,13,16)(H,14,17)/t5-/m0/s1

Chave InChI: InChIKey=KWNIHCJDDYRQFW-YFKPBYRVSA-N

SMILES: C(CCCNC(C(F)(F)F)=O)[C@H]1C(=O)OC(=O)N1

Sinónimos:

• (S)-N-(4-(2,5-dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide
• Acetamide, N-[4-(2,5-dioxo-4-oxazolidinyl)butyl]-2,2,2-trifluoro-, (S)-
• Acetamide, N-[4-[(4S)-2,5-dioxo-4-oxazolidinyl]butyl]-2,2,2-trifluoro-
• H-Lys(Tfa)-Nca
• N-Trifluoroacetyl-<span class="text-smallcaps">L</span>-lysine N-carboxyanhydride
• N-[4-[(4S)-2,5-Dioxo-4-oxazolidinyl]butyl]-2,2,2-trifluoroacetamide
• N-[4-[(4S)-2,5-Dioxooxazolidin-4-Yl]Butyl]-2,2,2-Trifluoro-Acetamide
• N-{4-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]butyl}-2,2,2-trifluoroacetamide
• N^ε-Trifluoroacetyl-<span class="text-smallcaps">L</span>-lysine N-carboxyanhydride
• N-Trifluoroacetyl-L-lysine N-carboxyanhydride
• Nε-Trifluoroacetyl-L-lysine N-carboxyanhydride
• 4-[(4S)-2,5-DIOXOOXAZOLIDIN-4-YL]BUTYL]-2,2,2-TRIFLUORO-ACETAMIDE
• Lysine-TFA-NCA
• (S)-N-[4-(2,5-Dioxo-4-oxazolidinyl)butyl]-2,2,2-trifluoroacetaMide
• Lys-NCA
• e-Trifluoroacetyl-Lysine, NCA
• L-Lys(TFA)-NCA
• Nepsilon-Trifluoroacetyl-Nalpha-carboxy-L-lysine Anhydride
• -N-(4-(2,5-Dioxooxazolidin-4-yl)
• N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
• N-(4-(2,5-Dioxo-4-oxazolidinyl)butyl)-2,2,2-trifluoroacetamide
• N-[3-[(4S)-2,5-dioxooxazolidin-4-yl]propyl]-2,2,2-trifluoro-acetaMide
• L-LYS(TFA)-NCA(42267-27-6)
• L-Lysine-N-Trifluoroacetyl-N-Carboxyanhydride
• N-trifluoroacetyl lysine N-carboxyanhydride

N-[4-[(4S)-2,5-DIOXOOXAZOLIDIN-4-YL]BUTYL]-2,2,2-TRIFLUORO-ACETAMIDE

CAS: 42267-27-6

Fórmula: C₉H₁₁F₃N₂O₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 268.1898

Ref: IN-DA00C0SG

(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide

CAS: 42267-27-6

(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide

Pureza: 98%

Peso molecular: 268.19g/mol

Ref: 54-PC99772

(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide

CAS: 42267-27-6

Fórmula: C₉H₁₁F₃N₂O₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 268.192

Ref: 10-F225539

N-Trifluoroacetyl-L-lysine N-Carboxyanhydride

CAS: 42267-27-6

Fórmula: C₉H₁₁F₃N₂O₄

Peso molecular: 268.19

Ref: 4Z-L-138044

N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride

CAS: 42267-27-6

Applications Used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers.  DGL polymers were prepd. through a multiple-generation scheme (up to generation 5) in a weakly acidic aq. medium by polycondensing N.vepsiln.-trifluoroacetyl-L-lysine-N-carboxyanhydride (Lys(Tfa)-NCA) onto the previous generation G(n-1) of DGL, which was used as a macroinitiator.
References Svenson, S., et al.: Adv. Drug Delivery Rev., 57, 2106 (2005), Shen, X., et al.: Org. Biomol. Chem., 5, 3674 (2007),

Fórmula: C₉H₁₁F₃N₂O₄

Cor e Forma: Neat

Peso molecular: 268.19

Ref: TR-T788530

N6-Trifluoroacetyl-L-lysine N-carboxyanhydride

CAS: 42267-27-6

Trifluoroacetyl-L-lysine N-carboxyanhydride is an N6-trifluoroacetylated lysine derivative that is used in the synthesis of peptides. It is a racemic mixture of L and D forms, which is hydrolyzed to form L-glutamic acid, NH4Cl, and CO2. Trifluoroacetyl-L-lyside N-carboxyanhydride has been shown to be useful in the formation of bonds between amino acids, such as lysine and dipeptides. The compound is also used for the protection of lysine against oxidation during peptide synthesis.

Fórmula: C₉H₁₁F₃N₂O₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 268.19 g/mol

Ref: 3D-FT28454

(S)-N-[4-(2,5-Dioxooxazolidin-4-yl)butyl]-2,2,2-trifluoroacetamide

CAS: 42267-27-6

Fórmula: C₉H₁₁F₃N₂O₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 268.19

Ref: 3B-D5600