CAS 433289-83-9

Atorvastatin Related Compound A (Calcium (3R,5R)-7-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate (1:2))

CAS: 433289-83-9

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Fórmula: C₆₆H₇₀CaN₄O₁₀

Cor e Forma: White Powder

Peso molecular: 1118.47179

Ref: 45-1044527

Atorvastatin EP Impurity A Calcium Salt (Atorvastatin USP Related Compound A, Defluoro Atorvastatin Calcium Salt)

CAS: 433289-83-9

Fórmula: C₃₃H₃₅N₂O₅·5Ca

Cor e Forma: White To Off-White Solid

Peso molecular: 539.65 0.5*40.08

Ref: 4Z-A-132

Arbutin-13C6

CAS: 433289-83-9, 433289-84-0

Fórmula: C₁₂H₁₆O₇

Peso molecular: 278.19

Ref: 4Z-A-132004

Defluoro Atorvastatin Calcium Salt

Produto Controlado

CAS: 433289-83-9

Impurity Atorvastatin USP Related Compound A
Stability Hygroscopic
Applications Desfluoro Atorvastatin is an impurity in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Gupta, L. et al.: Spect. Acta. Mol. Biomol. Spect., 97, 495 (2012); Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

Fórmula: C₃₃H₃₅N₂O₅·Ca

Cor e Forma: White To Off-White

Peso molecular: 1119.36

Ref: TR-D289875

Defluoro atorvastatin calcium

CAS: 433289-83-9

Defluoro atorvastatin calcium is a bulk drug that has been approved to be used as an adjunct to diet to reduce elevated cholesterol levels in adults. Defluoro atorvastatin calcium is the desfluoro-enantiomer of atorvastatin, which is a statin that inhibits the enzyme HMG-CoA reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonic acid, which is an early step in the synthesis of cholesterol. The fluoro group on defluoro atorvastatin calcium is not expected to have any significant effect on its potency or metabolic pathways and any impurities are not expected to have any therapeutic effect.

Fórmula: C₆₆H₇₀CaN₄O₁₀

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 1,119.36 g/mol

Ref: 3D-ID156826