CAS 442-51-3

Derivado de harmina

Descrição:

Derivado de harmina, identificado pelo número CAS 442-51-3, é um composto relacionado à harmina, que é um alcaloide beta-carbolina. Esta substância exibe várias características notáveis, incluindo seu papel como um inibidor reversível da monoamina oxidase A (MAO-A), o que é significativo no contexto da neurofarmacologia e das potenciais aplicações terapêuticas. Os Derivado de harmina são frequentemente estudados por suas propriedades psicoativas e uso potencial no tratamento de vários transtornos de saúde mental. Eles também podem exibir atividades antioxidantes e anti-inflamatórias, contribuindo para seu interesse na química medicinal. Estruturalmente, os Derivado de harmina normalmente contêm um sistema de anel fundido de indol e piridina, que é crucial para sua atividade biológica. Além disso, esses compostos podem interagir com vários sistemas de neurotransmissores, influenciando o humor e a cognição. O estudo dos Derivado de harmina continua a evoluir, com pesquisas em andamento explorando seu potencial farmacológico e mecanismos de ação no sistema nervoso central.

Fórmula: C₁₃H₁₂N₂O

InChI: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

Chave InChI: InChIKey=BXNJHAXVSOCGBA-UHFFFAOYSA-N

SMILES: CC1=C2C(C=3C(N2)=CC(OC)=CC3)=CC=N1

Sinónimos:

• 1-Methyl-7-methoxy-β-carboline
• 7-Methoxy-1-methyl-9H-beta-carbolin
• 7-Methoxy-1-methyl-9H-beta-carboline
• 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
• 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-
• Banisterin
• Banisterine
• Banisterine Monohydrate
• Harmin
• Harmine
• Leucoharmine
• Telepathin
• Telepathine
• Yagein
• Yageine
• 4-b)indole,7-methoxy-1-methyl-9h-pyrido(
• TELEPATHINE MONOHYDRATE
• 1-Methyl-7-methoxy-beta-carboline
• Telepathien
• PYRIDO(3,4-B)INDOLE,7-METHOXY-1-METHYL-
• Harmine,98+%
• HARMINE FREE BASE
• Garmin
• HARMINE MONOHYDRATE
• HARMAN MONOHYDROCHLORIDE MONOHYDRATE

Harmine

CAS: 442-51-3

Fórmula: C₁₃H₁₂N₂O

Pureza: >98.0%(T)

Cor e Forma: White to Orange to Green powder to crystal

Peso molecular: 212.25

Ref: 3B-H0001

Harmine

CAS: 442-51-3

Cor e Forma: Neat

Ref: 61-FOR2562.00

9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-

CAS: 442-51-3

Fórmula: C₁₃H₁₂N₂O

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 212.2472

Ref: IN-DA00I8E6

Harmine

CAS: 442-51-3

Harmine

Pureza: 98%

Cor e Forma: Beige Powder

Peso molecular: 212.25g/mol

Ref: 54-OR52246

Harmine

CAS: 442-51-3

Fórmula: C₁₃H₁₂N₂O

Pureza: 97.5 - 102.5 %

Cor e Forma: White to off-white crystalline powder

Peso molecular: 212.25

Ref: 7W-GP4309

Harmine

CAS: 442-51-3

Fórmula: C₁₃H₁₂N₂O

Pureza: 95%~99%

Peso molecular: 212.252

Ref: BP-BP0699

Harmine

CAS: 442-51-3

Harmine

Cor e Forma: Beige Powder

Peso molecular: 212.25g/mol

Ref: 54-BIDF1036

Harmine

CAS: 442-51-3

Fórmula: C₁₃H₁₂N₂O

Peso molecular: 212.25

Ref: 4Z-H-098001

Harmine

CAS: 442-51-3

Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.

Fórmula: C₁₃H₁₂N₂O

Pureza: 98.29% - 99.92%

Cor e Forma: Off-White Solid

Peso molecular: 212.25

Ref: TM-T1711

Harmine

CAS: 442-51-3

Natural alkaloid

Fórmula: C₁₃H₁₂N₂O

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 212.25

Ref: 5G-89702

Harmine

CAS: 442-51-3

Applications Harmine is a natural β-carboline alkaloid and a CNS stimulant (1,2). Harmine has been shown to be a potent and selective inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) (3). DYRK1A is a potential therapeutic target for treating diabetes, Down Syndrome, and HIV (4).
References (1) DiStefano, S., et al.: J. Pharmacol. Exp. Ther., 174, 456 (1970)(2) Dos Santos, R. G. and Hallak, J. E. J Psychoactive Drugs. 5,1 (2016) (3) Atteya, R., et al.: Mech Ageing Dev. 6, S0047 (2016)(4) Bol, S. M., et al.: PLoS One. 6, e17190 (2011)

Fórmula: C₁₃H₁₂N₂O

Cor e Forma: White To Brown

Peso molecular: 212.25

Ref: TR-H105250

Harmine

Produto Controlado

CAS: 442-51-3

Harmine is a molecule that interacts with DNA by binding to the minor groove, which is the non-helical area of DNA. Harmine has been shown to have cytotoxic properties in murine hepatoma cells, as well as anticancer activity in mouse tumor cells. Harmine also has antiviral and antimicrobial effects, and has been shown to inhibit the growth of human cancer cells. Harmine binds to Toll-like receptor 4 (TLR4), which is a pattern recognition receptor that plays an important role in innate immunity. Harmine inhibits TLR4 signaling, thereby inhibiting inflammatory responses such as acute toxicities. The molecular docking analysis of harmine shows that it has high affinity for polymerase chain reaction (PCR) enzymes and can be used for PCR inhibition studies. The analytical method for harmine was developed using a natural compound crystal structure as a model system.

Fórmula: C₁₃H₁₂N₂O

Peso molecular: 212.25 g/mol

Ref: 3D-H-1200

Harmine

CAS: 442-51-3

Fórmula: C₁₃H₁₂N₂O

Pureza: 99%

Cor e Forma: Solid, Very pale yellow to pale yellow powder

Peso molecular: 212.252

Ref: 10-F047259