CAS 442847-66-7

Cloridrato de éster p-nitrobenzílico de tienamicina (solvato de N-metilpirrolidinona)

Descrição:

Cloridrato de éster p-nitrobenzílico de tienamicina (solvato de N-metilpirrolidinona) é um composto sintético caracterizado por sua estrutura complexa, que inclui um núcleo de tienamicina, um grupo éster p-nitrobenzila e uma forma de sal hidroclorídrico. Este composto exibe potentes propriedades antibacterianas, particularmente contra bactérias Gram-negativas, devido à sua capacidade de inibir a síntese da parede celular bacteriana. A presença do éster p-nitrobenzila melhora seu perfil farmacológico, potencialmente aumentando sua biodisponibilidade e estabilidade. Como sal hidroclorídrico, é tipicamente mais solúvel em água, facilitando seu uso em várias formulações. O solvato de N-metilpirrolidinona indica que o composto pode formar interações estáveis com N-metilpirrolidinona, um solvente que pode influenciar sua solubilidade e comportamento de cristalização. No geral, o hidroclorídrico de tienamicina p-nitrobenzila é de interesse na química medicinal por suas potenciais aplicações terapêuticas, particularmente no desenvolvimento de novos antibióticos para combater cepas bacterianas resistentes.

Fórmula: C₁₈H₂₂ClN₃O₆S

InChI: InChI=1/C18H21N3O6S.ClH/c1-10(22)15-13-8-14(28-7-6-19)16(20(13)17(15)23)18(24)27-9-11-2-4-12(5-3-11)21(25)26;/h2-5,10,13,15,22H,6-9,19H2,1H3;1H/t10-,13-,15-;/m1./s1

Sinónimos:

• 2-{[(5R,6S)-6-[(1R)-1-hydroxyethyl]-2-{[(4-nitrobenzyl)oxy]carbonyl}-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl}ethanaminium chloride
• p-Nitrobenzyl(5R,6S)-2-(diphenylphosphoryloxy)-6-((1R)-1-hydroxyethyl)carbapen-2-em-3-carboxylate
• 3-[(2-Aminoethyl)thio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methylester monohydrochloride compd. with 1-methyl-2-pyrrolidinone (1:1)
• 4) THIENAMYCIN P-NITROBENZYLESTER HYDROCHLORIDE (N-METHYLPYRROLIDINONESOLVATE)
• IMIPENEM INTERMEDIATE
• 3-diphenoxyphosphinooxy-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
• THIENAMYCIN P-NITROBENZYLESTER HCL(N-METHYLPYRROLIDINONESOLVATE)
• N-METHYLPYRROLIDINONESOLVATE
• (5r,6s)-3-[(diphenoxyphosphinyl)oxy]-6-[(1r)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
• ThienaMycin p-nitrobenzylester, N-Methylpyrrolidinone HCl
• HYDROXYETHYL]-7-OXO-1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLICACID(4-NITROPHENYL)METHYLESTER
• P-NITROBENZYL (1R,5R,6S)-6-[(1R)-1-HYDROXYETHYL]-2-[(DIPHENYLPHOSPHONO)OXY]-CARBAPEN-2-EM-3-CARBOXYLATE
• (5R,6S)-3-(DIPHENOXY-PHOSPHORYLOXY)-6-(1-HYDROXY-ETHYL)-7-OXO-1-AZA-BICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID 4-NITRO-BENZYL ESTER
• INTERMEDIATE OF IMIPENEM
• PROTECTED THIENCIN HYDROCHLORIDE
• thienamycin p-nitrobenzylester hydrochloride (n-methylpyrrolidinonesolvate)
• THIENAMYCIN P-NITROBENZYL ESTER HYDROCHLORIDE
• (5R,6S)-3-(2-AMINO-ETHYLSULFANYL)-6-((R)-1-HYDROXY-ETHYL)-7-OXO-1-AZA-BICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID 4-NITRO-BENZYL ESTER, HYDROCHLORIDE
• p-Nitrobenzyl (5R,6S)-2-(diphenylphosphoryloxy)-6-

Thienamycin p-Nitrobenzyl Ester with N-Methylpyrrolidinone

Produto Controlado

CAS: 442847-66-7

Fórmula: C₁₈H₂₁N₃O₆S•C₅H₉NO•HCl

Cor e Forma: Neat

Peso molecular: 407.44 + 99.13 + (36.46)

Ref: TR-T182150

Thienamycin p-nitrobenzyl ester, N-methylpyrrolidinone hydrochloride

CAS: 442847-66-7

Thienamycin p-nitrobenzyl ester, N-methylpyrrolidinone hydrochloride is a synthetic compound commonly utilized in biochemical research, particularly in the study of beta-lactam antibiotics. It is derived through synthetic pathways involving the modification of thienamycin, a naturally occurring beta-lactam antibiotic, to enhance its stability and facilitate its study in various experimental settings. This modification allows for investigation into the structure-activity relationships and potential enhancements of antibiotic function.

Fórmula: C₂₃H₃₁ClN₄O₇S

Pureza: Min. 95%

Peso molecular: 543 g/mol

Ref: 3D-SSA84766