CAS 445493-23-2

(4R,7R,8S,9E,11S,12S)-8-(Acetiloxi)-4,7-diidroxi-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hidroxi-1-metilbutil]-2-oxiranyl]-1,5-dimetil-1,3-hexadien-1-il]-7,11-dimetiloxaciclododec-9-en-2-ona

Descrição:

A substância química com o nome "(4R,7R,8S,9E,11S,12S)-8-(Acetiloxi)-4,7-diidroxi-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hidroxi-1-metilbutil]-2-oxiranyl]-1,5-dimetil-1,3-hexadien-1-il]-7,11-dimetiloxaciclododec-9-en-2-ona" e o número CAS "445493-23-2" é um composto orgânico complexo caracterizado por sua estereoquímica intrincada e múltiplos grupos funcionais. Apresenta uma estrutura bicíclica com substituintes hidroxila e acetyloxi, indicando potencial atividade biológica, possivelmente como um produto natural ou um derivado dele. A presença de múltiplos centros quirais sugere que pode exibir interações estereoespecíficas em sistemas biológicos. Além disso, o composto contém um anel de oxirano, conhecido por sua reatividade, particularmente em reações de adição nucleofílica. Sua complexidade estrutural pode contribuir para propriedades únicas, como solubilidade e estabilidade, influenciando suas potenciais aplicações em produtos farmacêuticos ou agroquímicos. No geral, este composto exemplifica a diversidade das moléculas orgânicas e seus potenciais papéis em vários processos químicos e biológicos.

Fórmula: C₃₀H₄₈O₈

InChI: InChI=1S/C30H48O8/c1-8-24(33)21(5)29-25(37-29)16-18(2)10-9-11-19(3)28-20(4)12-13-26(36-22(6)31)30(7,35)15-14-23(32)17-27(34)38-28/h9-13,18,20-21,23-26,28-29,32-33,35H,8,14-17H2,1-7H3/b10-9+,13-12+,19-11+/t18-,20+,21-,23-,24+,25-,26+,28-,29-,30-/m1/s1

Chave InChI: InChIKey=SDOUORKJIJYJNW-QHOUZYGJSA-N

SMILES: C([C@@H](/C=C/C=C(\C)/[C@@H]1[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)CC(=O)O1)C)[C@@H]2[C@@]([C@@H]([C@H](CC)O)C)(O2)[H]

Sinónimos:

• Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-
• 11107B
• Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]oxiranyl]-1,5-dimethyl-1,3-hexadienyl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-
• (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
• Pladienolide B

Pladienolide B

CAS: 445493-23-2

Fórmula: C₃₀H₄₈O₈

Peso molecular: 536.6973

Ref: IN-DA00DKMX

Pladienolide B

CAS: 445493-23-2

Pladienolide B, a macrolide from Streptomyces, inhibits spliceosome's SF3B1, causing necrosis and antitumor effects for leukemia and lymphoid studies.

Fórmula: C₃₀H₄₈O₈

Pureza: 98.27% - 98.27%

Cor e Forma: Solid

Peso molecular: 536.7

Ref: TM-T16551

Pladienolide B

CAS: 445493-23-2

Pladienolide B is a natural macrocyclic compound, which is a secondary metabolite derived from the culture broth of the bacterium Streptomyces platensis. It functions as a selective inhibitor of the spliceosome, a complex responsible for pre-mRNA splicing. By binding to the SF3b subunit of the spliceosome, Pladienolide B disrupts normal splicing processes, leading to alterations in gene expression. This disruption affects the growth and survival of cancer cells, demonstrating significant antitumor activity in various cancer models.Pladienolide B's unique mechanism of targeting the spliceosome makes it a subject of interest in cancer research, particularly for malignancies resistant to conventional therapies. Its efficacy in preclinical studies highlights its potential as a lead compound for the development of novel anticancer drugs. Researchers investigate its applications in targeting specific cancer types, exploring synergies with other treatments, and understanding resistance mechanisms, making it an important tool in both basic research and therapeutic exploration.

Fórmula: C₃₀H₄₈O₈

Peso molecular: 536.7 g/mol

Ref: 3D-FP184560