CAS 4562-36-1
:Gitoxina
Descrição:
Gitoxina, com o número CAS 4562-36-1, é um glicosídeo cardíaco derivado da espécie vegetal Digitalis, comumente conhecida como dedaleira. É caracterizado por sua capacidade de inibir a enzima Na+/K+ ATPase, levando ao aumento das concentrações intracelulares de sódio e cálcio nas células cardíacas. Esse mecanismo aumenta a força das contrações cardíacas, tornando-o útil no tratamento de certas condições cardíacas, como fibrilação atrial e insuficiência cardíaca. Gitoxina apresenta um índice terapêutico estreito, o que significa que a diferença entre uma dose eficaz e uma dose tóxica é pequena, exigindo monitoramento cuidadoso dos níveis sanguíneos durante o tratamento. A substância também é conhecida por seus potenciais efeitos colaterais, que podem incluir distúrbios gastrointestinais, alterações visuais e arritmias. Assim como outros glicosídeos cardíacos, a farmacocinética de Gitoxina pode ser influenciada por fatores como a função renal e interações com outros medicamentos. Devido aos seus efeitos potentes e potencial toxicidade, Gitoxina deve ser utilizado sob rigorosa supervisão médica.
Fórmula:C41H64O14
InChI:InChI=1S/C41H64O14/c1-19-36(47)27(42)14-33(50-19)54-38-21(3)52-34(16-29(38)44)55-37-20(2)51-32(15-28(37)43)53-24-8-10-39(4)23(13-24)6-7-26-25(39)9-11-40(5)35(22-12-31(46)49-18-22)30(45)17-41(26,40)48/h12,19-21,23-30,32-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25+,26-,27+,28+,29+,30+,32+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1
Chave InChI:InChIKey=LKRDZKPBAOKJBT-CNPIRKNPSA-N
SMILES:O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5C[C@H](O)[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H]([C@@H](O)C2)C8=CC(=O)OC8)[H])[H]
Sinónimos:- (3beta,5beta,16beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14,16-dihydroxycard-20(22)-enolide
- (3beta,5beta,9xi,16beta)-3-{[(4xi)-2,6-dideoxy-D-erythro-hexopyranosyl-(1->4)-2,6-dideoxy-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14,16-dihydroxycard-20(22)-enolide
- (3β,5β,16β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14,16-dihydroxycard-20(22)-enolide
- 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-14,16-Dihydroxycard-20(22)-Enolide
- Anhydrogitalin
- Bigitalin
- Brn 0077015
- Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14,16-dihydroxy-, (3beta,5beta,16beta)- (9CI)
- Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14,16-dihydroxy-, (3β,5β,16β)-
- Gitoksin
- Gitoxigenin-tridigitoxosid
- Gitoxigenin-tridigitoxosid [German]
- Gitoxim
- Gitoxoside
- Nsc 95099
- Pseudodigitoixn
- Pseudodigitoxin
- Gitoxin
- Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14,16-dihydroxy-, (3β,5β,16β)-
- (3β,5β,16β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14,16-dihydroxycard-20(22)-enolide
- Gitoxin extrapure, 98%
- 20(22),5BETA-CARDENOLID-3BETA,14BETA,16BETA-TRIOL 3BETA-[O-BETA-D-DIGITOXOPYRANOSYL-(1->4)-O-BETA-D-DIGITOXOPYRANOSYL-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE]
- Gitoxin CRS
- Digoxin Impurity 15
- Anhydrogitalin, Pseudodigitoxin
- 16-Hydroxydigitoxin
- GINSENOSIDES KIT
- 3β-[[4-O-[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-14,16β-dihydroxy-5β-card-20(22)-enolide
- Digoxin EP Impurity B
- Digoxin IMpurity B
- Gitoxin (50 mg)
- ACETYL GITOXIN, 16-(RG)
- Gitoxin for Purity RS
- Ver mais sinónimos
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12 produtos.
Gitoxin
CAS:Gitoxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.Fórmula:C41H64O14Pureza:(HPLC) ≥98%Cor e Forma:PowderPeso molecular:780.95GITOXIN CRS
CAS:GITOXIN CRSFórmula:C41H64O14Cor e Forma:Crystalline Powder. White. Powder.Peso molecular:780.9385Gitoxin
CAS:Gitoxin is a natural Na⁺/K⁺-ATPase inhibitor and metabolite of digitoxin, antiarrhythmic with μM-level inhibition of human erythrocyte isoenzymes.Fórmula:C41H64O14Pureza:98%Cor e Forma:SolidPeso molecular:780.94Gitoxin
CAS:<p>Gitoxin is a protein analog that has been shown to increase the strength of heart tissue. It has been shown to be effective in treating congestive heart failure, which is characterized by symptoms such as shortness of breath and fatigue. Gitoxin also inhibits inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Gitoxin is a growth factor that stimulates the proliferation of human serum cells, with an effect on basic fibroblast growth factor (bFGF). Gitoxin has been shown to have cardiac effects and may inhibit cardiac arrhythmias by binding to the papillary muscle. There are kinetic studies that show gitoxin binding to the cardiac potassium channels and activating them.</p>Fórmula:C41H64O14Pureza:Min. 95%Cor e Forma:PowderPeso molecular:780.96 g/molGitoxin
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Gitoxin acts as in inhibitor of the sodium and potassium ion channels, interfering with ATPase activity and used in cancer treatment as a growth inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colovic, M. et al.: Russ. J. Phys. Chem. A., 83, 1602 (2009); Banuls, L. et al.: Mol. Canc., 12, 33 (2013);<br></p>Fórmula:C41H64O14Cor e Forma:NeatPeso molecular:780.94Ref: TR-G388750
Produto descontinuado
