CAS 4651-67-6

Ácido 7-cetolitocólico

Descrição:

Ácido 7-cetolitocólico é um derivado de ácido biliar que desempenha um papel no metabolismo de lipídios e na regulação dos níveis de colesterol no corpo. É caracterizado pelo seu grupo funcional cetona na posição C7 do núcleo esteroide, o que o distingue de outros ácidos biliares. Este composto é tipicamente encontrado na bile de certos animais e está envolvido na emulsificação de gorduras dietéticas, facilitando sua absorção nos intestinos. Sua estrutura inclui uma espinha dorsal esteroide hidrofóbica, que contribui para sua natureza anfipática, permitindo que interaja tanto com lipídios quanto com água. Ácido 7-cetolitocólico também pode exibir atividades biológicas, incluindo efeitos potenciais no metabolismo de lipídios e na microbiota intestinal. Como um ácido biliar, está sujeito à circulação entero-hepática, influenciando sua concentração e atividade no trato gastrointestinal. Compreender suas propriedades e funções é importante para a pesquisa em saúde gastrointestinal e distúrbios metabólicos.

Fórmula: C₂₄H₃₈O₄

InChI: InChI=1S/C24H38O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-19,22,25H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,22+,23+,24-/m1/s1

Chave InChI: InChIKey=DXOCDBGWDZAYRQ-AURDAFMXSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3=O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Sinónimos:

• (3Alpha,5Beta)-3-Hydroxy-7-Oxocholan-24-Oic Acid
• (3Alpha,5Beta,8Xi,9Xi,10Xi,13Xi,14Xi,17Xi,20Xi)-3-Hydroxy-7-Oxocholan-24-Oic Acid
• (3α,5β)-3-Hydroxy-7-oxo-Cholan-24-oic acid
• (3α,5β)-3-Hydroxy-7-oxocholan-24-oic acid
• 3-Hydroxy-7-Oxocholan-24-Oic Acid
• 3Alpha-Hydroxy-7-Oxo-5Beta-Cholanic Acid
• 3alpha-Hydroxy-7-oxo-5-cholanic acid
• 3alpha-Hydroxy-7-oxo-5beta-cholic acid
• 3α-Hydroxy-7-keto-5β-cholan-24-oic acid
• 3α-Hydroxy-7-keto-5β-cholanic acid
• 3α-Hydroxy-7-oxo-5β-cholan-24-oic acid
• 3α-Hydroxy-7-oxo-5β-cholan-24-oicacid
• 3α-Hydroxy-7-oxo-5β-cholanic acid
• 3α-Hydroxy-7-oxo-5β-cholanoic acid
• 3α-Hydroxy-7-oxo-5β-cholic acid
• 5β-Cholan-24-oic acid, 3α-hydroxy-7-oxo-
• 5β-Cholanic acid, 3α-hydroxy-7-oxo-
• 5β-Cholanic acid-3α-ol-7-one
• 7-Ketochenodeoxycholic acid
• 7-Ketolithocholic acid
• 7-Oxo-3α-hydroxycholan-24-oic acid
• 7-Oxolithocholic acid
• 7-keto-Lithocholic acid
• 7K-Lca
• Cholan-24-oic acid, 3-hydroxy-7-oxo-, (3α,5β)-
• Hydroxycholanicacid
• NSC 226118
• Nutriacholic acid
• Obeticholic Acid Intermediate

3α-Hydroxy-7-oxo-5β-cholanic Acid

CAS: 4651-67-6

Fórmula: C₂₄H₃₈O₄

Pureza: >97.0%(T)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 390.56

Ref: 3B-H0869

7-keto Lithocholic Acid

CAS: 4651-67-6

Fórmula: C₂₄H₃₈O₄

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 390.5561

Ref: IN-DA0035ZB

7-Ketolithocholic acid

CAS: 4651-67-6

7-Ketolithocholic acid

Pureza: ≥98%

Peso molecular: 390.56g/mol

Ref: 54-BUP18083

Ursodeoxycholic Acid EP Impurity F

CAS: 4651-67-6

Fórmula: C₂₄H₃₈O₄

Cor e Forma: White To Off-White Solid

Peso molecular: 390.56

Ref: 4Z-U-029

3-α-Hydroxy-7-Keto-5β-Cholanic Acid

CAS: 4651-67-6

3-α-Hydroxy-7-Keto-5β-Cholanic Acid

Pureza: 98%

Peso molecular: 390.56g/mol

Ref: 54-OR1029775

7-Oxolithocholic Acid

CAS: 4651-67-6

Fórmula: C24H38O4

Pureza: >98%

Cor e Forma: Solid

Peso molecular: 390.56

Ref: 48-65-1107

3a-Hydroxy-7-oxo-5b-cholanic acid

CAS: 4651-67-6

Pureza: 95.0%

Cor e Forma: Solid

Peso molecular: 390.5639953613281

Ref: 10-F242080

Ursodeoxycholic Acid EP Impurity F

CAS: 4651-67-6

Fórmula: C₂₄H₃₈O₄

Peso molecular: 390.56

Ref: ST-EA-CP-U1006

Nutriacholic Acid

CAS: 4651-67-6

Impurity Ursodeoxycholic Acid EP Impurity F
Applications Nutriacholic Acid (Ursodeoxycholic Acid EP Impurity F) is derivative of Lithocholic Acid (L469180), a cholic acid derivative as TGR5 modulator.
References Schneider, H., et al.: Bioorg. Med. Chem. Lett., 6, 637 (1996); Takamine, F., et al.: Microbiol. Immunol., 39, 11 (1995); Yamashita, H., et al.: Hepatol., 20, 663 (1994);

Fórmula: C₂₄H₃₈O₄

Cor e Forma: White To Off-White

Peso molecular: 390.56

Ref: TR-N925550

Nutriacholic Acid-d5

Produto Controlado

CAS: 4651-67-6

Fórmula: C₂₄D₅H₃₃O₄

Cor e Forma: Neat

Peso molecular: 395.587

Ref: TR-N925558

3a-Hydroxy-7-oxo-5b-cholanic acid

Produto Controlado

CAS: 4651-67-6

3a-Hydroxy-7-oxo-5b-cholanic acid (3OHC) is a metabolite of 7-oxo-5b-cholanate, which is synthesized from cholic acid by the bacterial strain Clostridium species. 3OHC has been shown to be a potent inhibitor of human serum primary sclerosing cholangitis, which is an inflammatory disease of the bile ducts in the liver. It functions by inhibiting the formation of hydroxyl radicals, which are reactive oxygen species that cause tissue injury. The hydroxyl group in 3OHC reacts with the sulfhydryl groups on cysteine residues in proteins and forms sulfenic acids, which react with hydrogen peroxide to form chemically stable products. 3OHC also inhibits bacterial growth by binding to DNA and inhibiting transcription and replication.

Fórmula: C₂₄H₃₈O₄

Pureza: Min. 95%

Peso molecular: 390.56 g/mol

Ref: 3D-FH75036

7-Ketolithocholic acid

CAS: 4651-67-6

7-Ketolithocholic acid absorbs and reduces endogenous bile acid and cholesterol secretion.

Fórmula: C₂₄H₃₈O₄

Pureza: 98.68% - 99.9%

Cor e Forma: White - Almost White Solid Powder

Peso molecular: 390.56

Ref: TM-T13522