CAS 472-15-1

Ácido betulínico

Descrição:

Ácido betulínico é um composto triterpenoide pentacíclico que ocorre naturalmente, derivado principalmente da casca da árvore de bétula (espécies de Betula). É caracterizado por sua aparência cristalina branca e possui uma fórmula molecular de C30H48O3. Ácido betulínico é conhecido por suas diversas atividades biológicas, incluindo propriedades anti-inflamatórias, antivirais e anticancerígenas. Tem sido estudado por seus potenciais efeitos terapêuticos contra vários tipos de câncer, pois pode induzir apoptose em células tumorais enquanto preserva células normais. Além disso, Ácido betulínico exibe propriedades antimicrobianas e mostrou promessas no tratamento de condições como HIV e outras infecções virais. Seu mecanismo de ação geralmente envolve a modulação de vias de sinalização celular e a indução de estresse oxidativo em células cancerosas. Devido à sua origem natural e bioatividade, Ácido betulínico é de grande interesse na pesquisa e desenvolvimento farmacêutico, embora mais estudos sejam necessários para entender completamente sua eficácia e segurança em aplicações clínicas.

Fórmula: C₃₀H₄₈O₃

InChI: InChI=1/C29H46O3/c1-17(2)18-9-15-29(25(31)32)16-10-20-19(24(18)29)7-8-22-27(20,5)13-11-21-26(3,4)23(30)12-14-28(21,22)6/h18-24,30H,1,7-16H2,2-6H3,(H,31,32)/t18-,19-,20?,21?,22?,23+,24?,27-,28-,29-/m0/s1

Chave InChI: InChIKey=QGJZLNKBHJESQX-FZFNOLFKSA-N

SMILES: C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

Sinónimos:

• (1R,3aS,5bS,9R,11aR,13aS)-9-hydroxy-5b,8,8,11a-tetramethyl-1-(1-methylethenyl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid
• (3Beta)-3-Hydroxylup-20(29)-En-28-Oic Acid
• (3Beta,5Xi,9Xi,13Xi,18Xi)-3-Hydroxylup-20(29)-En-28-Oic Acid
• (3β)-3-Hydroxylup-20(29)-en-28-oic acid
• 3-Hydroxylup-20(29)-en-28-oic acid
• 3aH-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv.
• 3β-Hydroxylup-20(29)-en-28-oic acid
• Acide Lupene-20(29) Oique-28, Hydroxy-3, (3Β)-
• Acido Lup-20(29)-En-28-Oico, 3-Hidroxi-, (3Β)-
• Betulic acid
• Ccris 6748
• Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-
• Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3β)-
• Lup-20(29)-en-28-oic acid, 3beta-hydroxy-
• Lup-20(29)-en-28-oic acid, 3β-hydroxy-
• Lup-20(29)-en-28-olsaure, 3-Hydroxy-, (3β)-
• Lupatic acid
• Mairin
• Nsc 113090
• Nsc 677578
• β-Betulinic acid
• Platanol
• BETULICACID: LUP-20(29)-EN-28-OICACID, 3-HYDROXY-, (3B)-,
• Betulinic
• (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentaMethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid
• BETULINIC ACID
• AIRIN
• 3-B-HYDROXY-LUPA-20(30)-ENE 28-OIC ACID
• 3BETA-HYDROXY-20(29)-LUPENE-28-OIC ACID
• Einecs 207-448-8
• Melaleucin
• Gratiolone
• 3BETA-HYDROXY-20(29)-LUPAENE-28-OIC ACID
• ALS-357
• BETULINIC ACID WITH HPLC
• 3β-hydroxy-20(29)-lupaene-28-oic acid
• BETULINIC ACID hplc
• 3B-HYDROXY-20(29)-LUPENE-28-OIC ACID
• Betulinic acid technical grade, 90%
• (+)-(3β)-3-Hydroxylup-20(29)-en-28-oicacid
• Lup-20(29)-en-28-oic acid, 3beta-hydroxy-(8ci)
• 3β-hydroxy-lup-20(29)-ene-28-oicacid
• Betulinic Acid(98%)
• Platanolic acid
• BETULINIC ACID, TECH., 90%

Betulinic acid

CAS: 472-15-1

Betulinic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₃₀H₄₈O₃

Pureza: (HPLC) ≥98%

Cor e Forma: Powder

Peso molecular: 456.71

Ref: 11-0031S

Betulinic acid

CAS: 472-15-1

Fórmula: C₃₀H₄₈O₃

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 456.7003

Ref: IN-DA003O6L

Betulinic acid

CAS: 472-15-1

Fórmula: C₃₀H₄₈O₃

Pureza: ≥ 97.0%

Cor e Forma: White to off-white or light-yellow powder

Peso molecular: 456.70

Ref: 7W-GP1450

Betulinic acid

CAS: 472-15-1

Betulinic acid

Pureza: ≥98%

Peso molecular: 456.7g/mol

Ref: 54-BUP16011

Betulinic acid

CAS: 472-15-1

Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, immunomodulatory, anti-inflammatory and anti-tumor properties.Betulinic acid is a selective inducer of apoptosis in tumor cells, it inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression induced by carcinogens and inflammatory stimuli.

Fórmula: C₃₀H₄₈O₃

Pureza: 95%~99%

Peso molecular: 456.711

Ref: BP-BP0271

Betulinic acid

CAS: 472-15-1

Betulinic acid

Fórmula: C₃₀H₄₈O₃

Pureza: 98%

Cor e Forma: white powder

Peso molecular: 456.70g/mol

Ref: 54-BIDF1001

Betulinic acid

CAS: 472-15-1

Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.

Fórmula: C₃₀H₄₈O₃

Pureza: 98.22% - 99.7%

Cor e Forma: White Crystalline Powder

Peso molecular: 456.70

Ref: TM-T2830

Betulinic acid with hplc

CAS: 472-15-1

Betulinic acid with hplc

Pureza: 98%

Peso molecular: 456.70g/mol

Ref: 54-BIDF1011

Betulinic acid

CAS: 472-15-1

Carboxylic acid with alcohol function

Fórmula: C₃₀H₄₈O₃

Pureza: ≥ 90.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 456.71

Ref: 5G-89529

Betulinic Acid

CAS: 472-15-1

Applications Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);

Fórmula: C₃₀H₄₈O₃

Cor e Forma: Neat

Peso molecular: 456.7

Ref: TR-B330250

Betulinic acid

CAS: 472-15-1

Betulinic acid is a pentacyclic triterpenoid, which is derived from the bark of birch trees among other plants. This compound exerts its effects primarily through the induction of apoptosis in cancer cells, interference with viral replication, and modulation of inflammatory pathways. Its mode of action includes mitochondrial membrane potential disruption, inhibition of topoisomerase, and interaction with the NF-kB signaling pathway.

Fórmula: C₃₀H₄₈O₃

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 456.7 g/mol

Ref: 3D-FB16425

3-epi-Betulinic Acid-d3

Produto Controlado

CAS: 472-15-1

Applications 3-epi-Betulinic Acid-d3 is an isotope labelled analog of Betulinic Acid (B330250); a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity. In addition, 3-epi-Betulinic Acid-d3 is an epimer by-product isomer of Betulinic Acid-d3 (B330252).
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)

Fórmula: C₃₀D₃H₄₅O₃

Cor e Forma: Neat

Peso molecular: 459.719

Ref: TR-B330251

Betulinic Acid

CAS: 472-15-1

Fórmula: C₃₀H₄₈O₃

Pureza: >97.0%(GC)(T)

Cor e Forma: White to Light yellow to Light orange powder to crystal

Peso molecular: 456.71

Ref: 3B-B2836

Betulinic acid

CAS: 472-15-1

M01408 - Betulinic acid

Fórmula: C₃₀H₄₈O₃

Pureza: 97%

Cor e Forma: Solid, Crystalline Powder or Powder

Peso molecular: 456.711

Ref: 10-M01408

Betulinic Acid-d3

Produto Controlado

CAS: 472-15-1

Applications Betulinic Acid-d3 is the isotope labelled analog of Betulinic Acid (B330250); a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity.
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)

Fórmula: C₃₀H₄₅D₃O₃

Cor e Forma: Neat

Peso molecular: 459.72

Ref: TR-B330252