CAS 486460-00-8

ácido [(1,1-dimetiletoxicarbonil)amino]-2,4,5-trifluoro-(R)-benzenobutanoico

Descrição:

A substância química conhecida como "ácido [(1,1-dimetiletoxicarbonil)amino]-2,4,5-trifluoro-(R)-benzenobutanoico," com o número CAS 486460-00-8, é um composto orgânico complexo caracterizado por seus grupos funcionais e características estruturais únicas. Contém um grupo amino, um ácido carboxílico e um grupo trifluorometílico, que contribuem para sua reatividade e potenciais aplicações em química medicinal. A presença do grupo 1,1-dimetiletoxicarbonilo sugere que pode servir como um grupo protetor em rotas sintéticas. Os substituintes trifluorometílicos aumentam a lipofilicidade e podem influenciar a atividade biológica, tornando este composto de interesse no design de fármacos. Além disso, a quiralidade indicada pela configuração (R) sugere que o composto pode exibir propriedades estereoespecíficas, o que pode ser crucial para sua interação com alvos biológicos. No geral, as características distintas deste composto o tornam um assunto valioso para pesquisa em síntese orgânica e desenvolvimento farmacêutico.

Fórmula: C₁₅H₁₈F₃NO₄

InChI: InChI=1/C15H18F3NO4/c1-15(2,3)23-14(22)19-9(6-13(20)21)4-8-5-11(17)12(18)7-10(8)16/h5,7,9H,4,6H2,1-3H3,(H,19,22)(H,20,21)/t9-/m1/s1

SMILES: CC(C)(C)OC(=N[C@H](Cc1cc(c(cc1F)F)F)CC(=O)O)O

Sinónimos:

• Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid
• (3R)-N-(Tert-Butoxycarbonyl)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid
• (3R)-3-(1,1-Dimethylethoxy Carbonyl) Amino]-4-(2,4,5-Trifluorophenyl) Butanoic Acid
• Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid
• (R)-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
• (R)-N-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
• (3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
• Benzenebutanoic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (3R)-
• Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
• (R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid
• (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
• (R)-3-(tert-butoxy carbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid
• 3(R)-tert-Butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid
• (R)-3-[(Tert-Butoxycarbonyl)amino]-4-(2,4,5-Trifluoro Phenyl)butanoic Acid
• (Tert-Butoxy)Carbonyl (R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid
• 5-TRIFLUORO-PHENYL)-BUTYRIC ACID
• Sitagliptin interMediate
• (3R)-N-Boc-3-amin
• Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate
• Parecoxib SodiuM API
• (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid
• N-Boc Sitagliptin Acid Impurity
• Sitagliptin EP Impurity 15
• (R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid
• (R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic&nbsp
• Sitagliptin N-BOC Carboxylic Acid
• Sitagliptin Impurity 19
• Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-
• (3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BU
• [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-be...
• Sitagliptin Intermediate 1
• Sitagliptin interMediateB
• Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
• Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-ButyricAci
• (βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid
• [[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta
• Sitagliptin Acid Boc Impurity (Impurity A)
• BOC-(R-)3-Amino-4(2,4,5-triflurophenyl)Butanoic acid
• BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ISO 9001：2015 REACH
• (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluoro phenyl)butanoic acid [Sita Acid]
• butanoic acid (BOC acid)
• (R)-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid
• Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (Boc acid)
• (3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl)
• Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
• Sitagliptin Impurity 78
• BOC-(R)-3-AMINO-4-(2
• (R)-Sitagliptin N-Boc-Acid IMpurity
• [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid
• (3R)-3-((1,1-DIMETHYLETHOXYCARBONYL)AMINO)-4-(2,4,5-TRIFLUROPHENYL)-BUTANOIC ACID
• 4-(6-{[(tert-butoxy)carbonyl]aMino}-1,2,5-trifluorocyclohexa-2,4-dien-1-yl)butanoic acid
• Boc-(R)-3-Amino-4-(2,4,5-trifluorphenyl)butanoic acid
• SITAGLIPTIN CAS 654671-78-0 INTERMEDIATES
• BOC- Butanoic Acid
• Sitagliptin N-BOC Carboxylic acid Impurity
• (3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
• Sitagliptin Imp-1(sitagliptin Impurity-A)
• Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%
• BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY
• Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity)
• (R)-3-(Boc-aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
• (3R) - N - (tert butoxycarbonyl) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

CAS: 486460-00-8

Fórmula: C₁₅H₁₈F₃NO₄

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 333.3029

Ref: IN-DA0038OZ

Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity)

CAS: 486460-00-8

Fórmula: C₁₅H₁₈F₃NO₄

Cor e Forma: White To Off-White Solid

Peso molecular: 333.31

Ref: 4Z-S-2025

(3R)-3-[(1,1-Dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

CAS: 486460-00-8

(3R)-3-[(1,1-Dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Pureza: 98%

Peso molecular: 333.306g/mol

Ref: 54-PC99712

(3R)-3-(tert-Butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic Acid

CAS: 486460-00-8

Cor e Forma: Neat

Ref: 86-MM3378.05

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid

Produto Controlado

CAS: 486460-00-8

Applications (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.
References Kim, H.J., et. al.: Bioorg. Med. Chem. Lett., 22, 5545 (2012)

Fórmula: C₁₅H₁₈F₃NO₄

Cor e Forma: Neat

Peso molecular: 333.30

Ref: TR-B692330

N-Boc Sitagliptin Acid Impurity

CAS: 486460-00-8

Fórmula: C₁₅H₁₈F₃NO₄

Peso molecular: 333.31

Ref: ST-EA-CP-S3014

(R)-N-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

CAS: 486460-00-8

Fórmula: C₁₅H₁₈F₃NO₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 333.307

Ref: 10-F213484

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

CAS: 486460-00-8

Intermediate in the synthesis of sitagliptin

Fórmula: C₁₅H₁₈F₃NO₄

Pureza: Min. 95%

Peso molecular: 333.3 g/mol

Ref: 3D-FB29150