CAS 50-02-2

Dexametasona

Descrição:

Dexametasona é um corticosteroide sintético com propriedades anti-inflamatórias e imunossupressoras, comumente utilizado no tratamento de várias condições, como alergias, doenças autoimunes e certos tipos de câncer. Sua fórmula química é C22H29FO5, e apresenta uma estrutura esteroide com um átomo de flúor e um grupo cetona, contribuindo para sua potência. Dexametasona atua ligando-se aos receptores de glicocorticoides, influenciando a expressão gênica e modulando a resposta imunológica. É tipicamente administrado por via oral, intravenosa ou por injeção, e seus efeitos podem incluir redução da inflamação e supressão do sistema imunológico. A substância é conhecida por sua meia-vida relativamente longa em comparação com outros corticosteroides, permitindo uma dosagem menos frequente. Os efeitos colaterais podem incluir ganho de peso, mudanças de humor e aumento do risco de infecções, particularmente com o uso prolongado. Dexametasona também é notável por seu papel no manejo de casos graves de COVID-19, onde demonstrou melhorar os resultados em pacientes que necessitam de oxigênio ou ventilação mecânica.

Fórmula: C₂₂H₂₉FO₅

InChI: InChI=1/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16+,17+,19+,20+,21+,22+/m1/s1

Chave InChI: InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Sinónimos:

• (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• (8Xi,11Beta,16Alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• 1-Dehydro-16α-methyl-9α-fluorohydrocortisone
• 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 16α-Methyl-9α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
• 16α-Methyl-9α-fluoro-Δ1-hydrocortisone
• 16α-Methyl-9α-fluoro-Δ¹-hydrocortisone
• 16α-Methyl-9α-fluoroprednisolone
• 9-Alpha-Fluoro-11-Beta,17-Alpha,21-Trihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 9-Alpha-Fluoro-16-Alpha-Methylprednisolone
• 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
• 9α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
• 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 9α-Fluoro-16α-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
• 9α-Fluoro-16α-methylprednisolone
• Adexone
• Aeroseb-Dex
• Aphtasolon
• Aphthasolone
• Azium
• Calonat
• Corsone
• Cortisumman
• Decacort
• Decaderm
• Decadron
• Decalix
• Decasone
• Dekacort
• Dekort
• Delipos
• Deltafluorene
• Dergramin
• Deronil
• Desadrene
• Desameton
• Deseronil
• Dexa-Cortidelt
• Dexa-Mamallet
• Dexa-Scheroson
• Dexa-sine
• Dexacort
• Dexacortal
• Dexacortin
• Dexadeltone
• Dexafarma
• Dexalona
• Dexaltin
• Dexametasona
• Dexameth
• Dexamethason
• Dexamonozon
• Dexapolcort
• Dexapos
• Dexaprol
• Dexaratiopharm
• Dexason
• Dexasone
• Dexaven
• Dexinoral
• Dexium
• Dexmethsone
• Dexone
• Dexonium
• Dextelan
• Dinormon
• Diodex
• Etacortilen
• Fluormethylprednisolone
• Fluormone
• Fluorocort
• Gammacorten
• Gentalipos
• HL-Dex
• Hexadecadrol
• Hexadrol
• Isopto-Dex
• Loverine
• Luxazone
• Maxidex
• Millicorten
• Minidex
• Neofordex
• Oftan
• Oradexon
• Ozurdex
• Posurdex
• Superprednol
• Surodex
• Visumetazone
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16α)-
• MK 125
• DEXAMETHASONE BASE
• DEXAMETHASONE
• (11B,16A)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-PREGNA-1,4-DIENE-3,20-DIONE
• 1,4-PREGNADIENE-3,20-DIONE-9ALPHA-FLUORO-16ALPHA METHYL-11BETA,17ALPHA,21-TRIOL
• 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
• 9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
• 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE
• PREDNISOLONE F
• (11BETA,16ALPHA)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
• 1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE
• DECACORTIN
• 9ALPHA-FLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYL-1,4-PREGNADIENE 3,20DIONE

Dexamethasone-d3

Produto Controlado

CAS: 50-02-2

Applications Dexamethasone-d3 is the labelled form of Dexamethasone (D298800), which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T-cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Fórmula: C₂₂H₂₆D₃FO₅

Cor e Forma: Off-White To Light Beige

Peso molecular: 395.48

Ref: TR-D298803

Dexamethasone Acetate EP Impurity A

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Peso molecular: 392.47

Ref: ST-EA-CP-D17031

Dexamethasone

Produto Controlado

CAS: 50-02-2

Impurity Dexamethasone Sodium Phosphate EP Impurity A
Applications Dexamethasone (Dexamethasone Sodium Phosphate EP Impurity A) is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);

Fórmula: C₂₂H₂₉FO₅

Cor e Forma: Neat

Peso molecular: 392.46

Ref: TR-D298800

Dexamethasone Sodium phosphate EP Impurity A

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Peso molecular: 392.47

Ref: ST-EA-CP-D105001

Betamethasone EP Impurity A

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Peso molecular: 392.46

Ref: ST-EA-CP-B25001

Dexamethasone 21-Formate

Produto Controlado

CAS: 50-02-2

Applications Dexamethasone 21-Formate is a metabolite of Dexamethasone.
References Minagawa, K., et al.: Steroids, 47, 175 (1986), Murray, G., et al.: Br. J. Clin. Pharmacol., 25, 465 (1988), Ravichandran, K., et al.: Science, 1993, 261, 731 (1993),

Fórmula: C₂₃H₂₉FO₆

Cor e Forma: Neat

Peso molecular: 420.47

Ref: TR-D298910

Dexamethasone base

Produto Controlado

CAS: 50-02-2

Dexamethasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is often used to treat various ocular conditions, such as macular edema, retinal detachment, and uveitis. Dexamethasone has been shown to inhibit the migration of leukocytes into the vitreous humor of the eye by binding to glucocorticoid receptors in the cells that line blood vessels in the retina. Dexamethasone also binds to signal peptides on proteins that regulate mitochondrial functions and glucose uptake in cells. This drug can be used for bowel disease treatment, chronic cough management, or as an injection during polymerase chain reactions.

Fórmula: C₂₂H₂₉FO₅

Pureza: Min. 96 Area-%

Cor e Forma: Powder

Peso molecular: 392.46 g/mol

Ref: 3D-FD15640

Dexamethasone Regiomer

Produto Controlado

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Cor e Forma: Neat

Peso molecular: 392.47

Ref: TR-D358235

DEXAMETHASONE

CAS: 50-02-2

Fórmula: C₂₂H₂₉FO₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 392.4611

Ref: IN-DA0034OW

Dexamethasone 1.0 mg/ml in Methanol

CAS: 50-02-2

Cor e Forma: Single Solution

Ref: 61-AMP0213.00-01