CAS 50-07-7
:Mitomicina C
Descrição:
Mitomicina C é um potente antibiótico antitumoral derivado da bactéria Streptomyces caespitosus. É classificado como um agente alquilante, o que significa que interfere na síntese e função do DNA, tornando-se eficaz no tratamento de vários tipos de câncer, particularmente em casos de tumores de bexiga e gastrointestinal. O composto exibe um mecanismo de ação único ao formar ligações cruzadas entre as cadeias de DNA, levando, em última instância, à morte celular. Mitomicina C é tipicamente administrado por via intravenosa e é conhecido por seus efeitos citotóxicos, que podem resultar em efeitos colaterais significativos, incluindo mielossupressão, náuseas e potencial toxicidade orgânica. Sua estrutura química apresenta um grupo quinona, que desempenha um papel crucial em sua reatividade e atividade biológica. Devido à sua eficácia, Mitomicina C é frequentemente utilizado em combinação com outros agentes quimioterápicos para melhorar os resultados terapêuticos. No entanto, o monitoramento cuidadoso é essencial durante o tratamento para gerenciar os efeitos adversos e garantir a segurança do paciente.
Fórmula:C15H18N4O5
InChI:InChI=1/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7?,13+,15-/m0/s1
Chave InChI:InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N
SMILES:O(C)[C@]12N(C3=C([C@H]1COC(N)=O)C(=O)C(N)=C(C)C3=O)C[C@]4([C@@]2(N4)[H])[H]
Sinónimos:- (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione
- (6-Amino-8A-Methoxy-5-Methyl-4,7-Dioxo-1,1A,2,4,7,8,8A,8B-Octahydroazireno[2',3':3,4]Pyrrolo[1,2-A]Indol-8-Yl)Methyl Carbamate
- 6-Amino-1,1A,2,8,8A,8B-Hexahydro-8-(Hydroxymethyl)-8A-Methoxy-5-Methylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione Carbamate (Ester)
- Ametycine
- Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
- Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
- Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-
- Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
- Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
- Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-
- MMC
- MitoExtra
- Mitocin C
- Mitomicina
- Mitomycin C
- Mitomycin C, Streptomyces caespitosus
- Mitomycine
- Mitonco
- Mitoplus
- Mitozytrex
- Mutamycin
- Mytomycin C
- Mytomycin Kyowa S
- Nsc 26980
- [(1aR,8R,8aS,8bR)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
- [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
- [(8R,8aS,8bR)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
- [1Ar-(1Aalpha,8Beta,8Aalpha,8Balpha)]-6-Amino-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-8A-Methoxy-5-Methylazirino[2',3':3,4]Pyrrolo[1,2-Alpha]Indole-4,7-Dione
- mitomycin C from streptomyces*caespitosus
- tomycin C
- azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy
- 8aalpha,8balpha))-(9ci)
- azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox
- 8balpha)]-8aalph
- azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahy
- mitomycynac
- )methyl)-1,1a,2,8,8a,8b-hexahydro-8-a-methoxy-5-methyl-,(1as-(1aalpha,8beta,
- 7-amino-9-alpha-methoxymitosane
- AMETYCIN
- MITOMYCIN
- mitomycynac(polish)
- Ver mais sinónimos
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17 produtos.
Ametycin
CAS:Fórmula:C15H18N4O5Pureza:>98.0%(HPLC)Cor e Forma:Dark red to Dark purple to Dark blue powder to crystalPeso molecular:334.33Mitomycin C, 5 mg/ml in DMSO, sterile-filtered
CAS:<p>Mitomycin C, 50-07-7, is an antibiotic and anti-tumor agent which inhibits DNA synthesis by forming DNA crosslinks. Learn more at Thermo Fisher Scientific.</p>Fórmula:C15H18N4O5Cor e Forma:LiquidPeso molecular:334.33Mitomycin
CAS:<p>Antibiotics nesoi</p>Fórmula:C15H18N4O5Cor e Forma:Blue Violet PowderPeso molecular:334.12772Mitomycin C, 4% (with sodium chloride)
CAS:Fórmula:C15H18N4O5Cor e Forma:Grey to blue-purple powderPeso molecular:334.33Mitomycin C
CAS:Fórmula:C15H18N4O5Pureza:(HPLC) ≥ 98.0%Cor e Forma:Grey, violet or blue powderPeso molecular:334.33Mitomycin C
CAS:<p>Mitomycin C</p>Fórmula:C15H18N4O5Pureza:By hplc: 99.1% (Typical Value in Batch COA)Cor e Forma: blue-violet solidPeso molecular:334.33g/molMitomycin C
CAS:<p>Mitomycin C (Ametycine) is an antineoplastic agent and DNA double-strand crosslinking agent capable of inducing DNA damage, inhibiting DNA synthesis, suppressing mitosis, and activating apoptosis. Mitomycin C is a broad-spectrum antibiotic against both Gram-negative and Gram-positive bacteria.</p>Fórmula:C15H18N4O5Pureza:99.35%Cor e Forma:SolidPeso molecular:334.37Mitomycin 100 µg/mL in Acetonitrile
CAS:Produto ControladoFórmula:C15H18N4O5Cor e Forma:Single SolutionPeso molecular:334.33Mitomycin C
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Mitomycin C is an antitumor antibiotic. It is antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986),<br></p>Fórmula:C15H18N4O5Cor e Forma:VioletPeso molecular:334.33Mitomycin C - Bio-X ™
CAS:<p>Mitomycin C is a cytotoxic agent that belongs to the class of mitomycins. It has been used for the treatment of a range of cancers and for ocular surface diseases, such as the glaucoma surgery trabeculectomy. In this case it is administered to reduce post-operative scarring which could otherwise lead to failure of the procedure. Mitomycin C is an alkylating antibiotic that inhibits DNA synthesis by cross-linking the DNA double helix. Mitomycin C also stimulates the production of transforming growth factor β1 (TGF-β1) and basic fibroblast growth factor (bFGF). Clinically, mitomycin can be used both intravenously and topically, and has been studied in a range of wound healing models.</p>Fórmula:C15H18N4O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:334.33 g/molMitomycin C
CAS:<p>Chemoterapeutic agent; DNA crosslinker</p>Fórmula:C15H18N4O5Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:334.33 g/molMitomycin C - High Purity
CAS:<p>Mitomycin C is a cytotoxic agent that inhibits DNA synthesis. This product is tested according to USP specification. Mitomycin C has been shown to be effective against resistant mutants and carcinoma cell lines. It also has genotoxic activity and induces statistically significant chromosome aberrations in mammalian cells. Mitomycin C is toxic to the mitochondria, which may be due to its ability to induce mitochondrial membrane potential collapse, leading to apoptosis. Mitomycin C binds to the response element in the genome, causing transcriptional repression of a number of genes involved in cell proliferation, differentiation, or apoptosis. Mitomycin C inhibits squamous carcinoma cells by binding to their DNA and preventing RNA synthesis.</p>Fórmula:C15H18N4O5Pureza:Cas Rn [50-07-7] M. F. C15H18N4O5Cor e Forma:PowderPeso molecular:334.33 g/mol
