CAS 50-76-0

Dactinomicina

Descrição:

Dactinomicina, também conhecido como actinomicina D, é um potente antibiótico e agente quimioterápico derivado da bactéria Streptomyces parvulus. É caracterizado por sua complexa estrutura polipeptídica, que inclui um anel de fenoxazona e uma série de aminoácidos. Dactinomicina funciona principalmente intercalando-se no DNA, inibindo assim a síntese de RNA e interrompendo a síntese de proteínas, tornando-o eficaz contra vários tipos de câncer, particularmente em oncologia pediátrica para tratar o tumor de Wilms e o rabdomiosarcoma. O composto é tipicamente administrado por via intravenosa e é conhecido por suas propriedades citotóxicas, que podem levar a efeitos colaterais significativos, incluindo mielossupressão e distúrbios gastrointestinais. Dactinomicina é classificado como um medicamento da categoria D na gravidez devido aos seus potenciais efeitos teratogênicos. Sua estabilidade é influenciada por fatores como pH e exposição à luz, exigindo manuseio e armazenamento cuidadosos. No geral, Dactinomicina continua sendo um agente importante no arsenal contra certas malignidades, apesar de seus riscos e efeitos colaterais associados.

Fórmula: C₆₂H₈₆N₁₂O₁₆

InChI: InChI=1/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1

Sinónimos:

• 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-
• Hbf 386
• Lyovac cosmegen
• Meractinomycin
• Oncostatin K
• X 97
• Actactinomycin A IV
• Actinomycin 7
• Actinomycin AIV
• Actinomycindioic D acid, dilactone
• Actinomycin C1
• Actinomycin Cl
• Actinomycin D
• Actinomycin I
• Actinomycin I1
• Actinomycin IV
• Actinomycin-[threo-val-pro-sar-meval]
• Actinomycin X 1
• Actinomycin X I
• Actinomyein-Theo-Val-Pro-Sar-Meval
• Acto-D
• AD
• Dilactone actinomycindioic D acid
• Dilactone actinomycin D acid
• C1
• Cosmegen
• Dactinomycin D
• Dactinomyein D
• 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxooctadecahydrocyclopenta[i][1,4,7,13]oxatriazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• Actd
• 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-
• Actinomycin X1
• C 1
• Chounghwamycin B
• Dactinomicina
• Dactinomycine
• Nci C04682
• Nsc 3053

Actinomycin D (1 mg/ml, DMSO)

CAS: 50-76-0

Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm?s tumor and the sarcomas. This Thermo

Fórmula: C₆₂H₈₆N₁₂O₁₆

Cor e Forma: Liqiud, Clear Yellow to Orange to Dark Orange-Red

Peso molecular: 1255.44

Ref: 02-J67160

Actinomycin D

CAS: 50-76-0

Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues.

Fórmula: C₆₂H₈₆N₁₂O₁₆

Cor e Forma: Crystalline powder

Peso molecular: 1255.44

Ref: 02-J60148

Dactinomycin

CAS: 50-76-0

Antibiotics nesoi

Fórmula: C₆₂H₈₆N₁₂O₁₆

Cor e Forma: Red Crystalline Powder

Peso molecular: 1254.62847

Ref: 45-1162400

Actinomycin D

CAS: 50-76-0

Fórmula: C₆₂H₈₆N₁₂O₁₆

Pureza: 95.0 - 103.0 % (dried basis)

Cor e Forma: Red to orange crystalline powder

Peso molecular: 1255.40

Ref: 7W-GA0481

Dactinomycin

CAS: 50-76-0

Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator , inhibits transcription DNA, serving as a chemotherapy drug for cancer treatment.

Fórmula: C₆₂H₈₆N₁₂O₁₆

Pureza: 99.70%

Cor e Forma: Solid

Peso molecular: 1255.42

Ref: TM-TN9827

Actinomycin D

CAS: 50-76-0

Actinomycin D

Fórmula: C₆₂H₈₆N₁₂O₁₆

Pureza: 99%

Cor e Forma: shiny red to orange powder

Peso molecular: 1,255.42g/mol

Ref: 54-BIA0175

Actinomycin D, GlenCell™, suitable for cell culture, USP grade

CAS: 50-76-0

Fórmula: C₆₂H₈₆N₁₂O₁₆

Pureza: 950 - 1030 μg/mg (C62H86N12O16, dried basis)

Cor e Forma: Red to orange crystalline powder

Peso molecular: 1255.40

Ref: 7W-GA7901

Actinomycin D

CAS: 50-76-0

M01247 - Actinomycin D

Fórmula: C₆₂H₈₆N₁₂O₁₆

Pureza: >98%

Cor e Forma: Crystalline

Peso molecular: 1255.438

Ref: 10-M01247

Actinomycin D (Dactinomycin)

CAS: 50-76-0

Fórmula: C₆₂H₈₆N₁₂O₁₆

Peso molecular: 1255.44

Ref: 4Z-A-395001

Actinomycin D (Dactinomycin)

Produto Controlado

CAS: 50-76-0

Applications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),

Fórmula: C₆₂H₈₆N₁₂O₁₆

Cor e Forma: Red

Peso molecular: 1255.42

Ref: TR-D102500

Dactinomycin

CAS: 50-76-0

Actinomycin D is an antibiotic commonly used in chemotherapy for cancer treatment, such as sarcomas, and pediatric solid tumors, Wilm’s tumor, testicular cancer, and choriocarcinoma; it is generally not very useful in antibiotic therapy. It acts as a transcription inhibitor, binding to DNA duplexes at the transcription initiation complex and preventing RNA polymerase elongation.

Fórmula: C₆₂H₈₆N₁₂O₁₆

Pureza: Min. 95%

Cor e Forma: Red Powder

Peso molecular: 1,255.42 g/mol

Ref: 3D-AD20776

Actinomycin D (AMD) ex. Streptomyces Sp., 98%

CAS: 50-76-0

Fórmula: C₆₂H₈₆N₁₂O₁₆

Pureza: min. 98%

Cor e Forma: Red, Crystalline powder

Peso molecular: 1255.45

Ref: SR-28269