CAS 508-75-8

Convallatoxina

Descrição:

Convallatoxina é um glicosídeo cardíaco tóxico derivado da planta Convallaria majalis, comumente conhecida como lírio do vale. É caracterizado por sua capacidade de inibir a enzima Na+/K+ ATPase, que desempenha um papel crucial na manutenção do gradiente eletroquímico através das membranas celulares. Essa inibição leva a um aumento nos níveis de sódio intracelular, causando subsequentemente um aumento nas concentrações de cálcio intracelular, o que pode aumentar a contratilidade cardíaca. Convallatoxina exibe uma estrutura típica dos glicosídeos cardíacos, apresentando um núcleo esteroide com um grupo de açúcar. Seus efeitos farmacológicos podem levar a sintomas de toxicidade, incluindo náuseas, vômitos e arritmias potencialmente fatais. Devido à sua potente atividade biológica, Convallatoxina tem sido estudado por suas potenciais aplicações terapêuticas, embora sua estreita janela terapêutica exija cautela. O manuseio deste composto requer medidas de segurança adequadas devido à sua natureza tóxica, e é classificado como uma substância perigosa. No geral, Convallatoxina exemplifica a complexa interação entre produtos naturais e farmacologia, destacando tanto seus benefícios potenciais quanto seus riscos.

Fórmula: C₂₉H₄₂O₁₀

InChI: InChI=1/C29H42O10/c1-15-22(32)23(33)24(34)25(38-15)39-17-3-8-27(14-30)19-4-7-26(2)18(16-11-21(31)37-13-16)6-10-29(26,36)20(19)5-9-28(27,35)12-17/h11,14-15,17-20,22-25,32-36H,3-10,12-13H2,1-2H3/t15-,17-,18+,19?,20?,22-,23+,24+,25-,26+,27-,28-,29-/m0/s1

Chave InChI: InChIKey=HULMNSIAKWANQO-JQKSAQOKSA-N

SMILES: C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C5=CC(=O)OC5)(CC[C@]1(O)C[C@@H](O[C@H]6[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O6)CC2)[H])[H]

Sinónimos:

• (3beta,5beta)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,17xi)-3-[(6-deoxy-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,8xi,9xi)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3β,5β)-3-[(6-Deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• 3-[(6-Deoxyhexopyranosyl)Oxy]-5,14-Dihydroxy-19-Oxocard-20(22)-Enolide
• 3beta-((6-Deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-5beta-card-20(22)-enolide
• Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)-
• Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)- (9CI)
• Card-20(22)-enolide, 3-[(6-deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• Convallaotoxin
• Convallaton
• Convallatoxine
• Convallatoxoside
• Convallotoxin
• Corglycon
• Corglycone
• Corglykon
• Hsdb 3475
• Korglykon
• Mannopyranoside, strophanthidin-3,6-deoxy-, alpha-L-
• Nsc 407808
• Rhamnoside, strophanthidin-3, alpha-L-
• Strophanthidin alpha-L-rhamnoside
• Strophanthidin α-<span class="text-smallcaps">L</span>-rhamnoside
• Strophanthidin, 3-(6-deoxy-alpha-L-mannopyranoside)
• (3β,5β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Convallatoxin
• Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• 3BETA,5ALPHA,14-TRIHYDROXY-19-OXO-5BETA,20[22]-CARDENOLIDE-3-[6-DEOXY-ALPHA-L-MANNOPYRANOSYL]
• CONVALLATOXIN(RG)
• 6-deoxy-strophanthidin-alpha-l-mannopyranosid
• 20(22),5BETA-CARDENOLID-19-AL-3BETA,5BETA,14BETA-TRIOL-3BETA-D-[A-1-RHAMNOPYRANOSIDE]
• 0(22)-enolide
• Convallatoxin (=Corglycon)
• STROPHANTHIDIN A-L-RHAMNOPYRANOSIDE
• 3β-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β,14β-card-20(22)-enolide
• STROPHANTHIN 3ALPHA-1-RHAMNOSIDE
• 3β5α14-Trihydroxy-19-oxo-5β20(22)-cardenolide 3-(6-deoxy-α-L-mannopyranoside)
• (5S,10S,13R,14S)-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(3,4,5-trihydroxy-6-methyl-2-oxanyl)oxy]-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carboxaldehyde
• CONVALLATOXIN USP/EP/BP
• 3beta-[(6-deoxy-alpha-l-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5beta-card-2
• strophanthidin-3,alpha-l-rhamnosid
• Convapur
• (3beta,5beta)-oxo
• Convalpur
• Strophanthidin α-L-rhamnopyranoside, 3β,5α,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide 3-(6-deoxy-α-L-mannopyranoside)
• 5BETA,20[22]-CARDENOLIDE-19-ONE-3BETA,5ALPHA,14-TRIOL-3-[6-DEOXY-ALPHA-L-MANNOPYRANOSYL]
• 3β-(α-L-Rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5β,14β-carda-20(22)-enolide
• 3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-5,14-dihydroxy-19-card-20(22)-enolid
• Strophanthidin α-L-rhamnopyranoside
• orglycon
• strophanthidinalpha-l-rhamnoside
• CONVALLATOXIN(P)
• Convallopan

Convallatoxin

CAS: 508-75-8

Convallatoxin

Pureza: ≥98%

Peso molecular: 550.64g/mol

Ref: 54-BUP00478

Convallatoxin

CAS: 508-75-8

Fórmula: C₂₉H₄₂O₁₀

Peso molecular: 550.65

Ref: 7W-GY9874

Convallatoxin

CAS: 508-75-8

Fórmula: C₂₉H₄₂O₁₀

Pureza: 95%~99%

Peso molecular: 550.645

Ref: BP-BP0389

Convallatoxin

CAS: 508-75-8

Convallatoxin is a natural product.

Fórmula: C₂₉H₄₂O₁₀

Pureza: 99.27% - 99.53%

Cor e Forma: Prisms From Methanol + Ether Solid

Peso molecular: 550.64

Ref: TM-TN1525

Convallatoxin

CAS: 508-75-8

Natural glycoside

Fórmula: C₂₉H₄₂O₁₀

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 550.65

Ref: 5G-80834

Convallatoxin

CAS: 508-75-8

Convallatoxin is a cardiac glycoside, which is derived from the plant Convallaria majalis, commonly known as lily of the valley. This compound operates by specifically inhibiting the Na+/K+-ATPase enzyme, a crucial membrane-bound ion pump that maintains the electrochemical gradients of sodium and potassium ions across the cell membrane. Inhibition of this enzyme leads to an increase in intracellular sodium levels, subsequently affecting calcium ion exchange and resulting in enhanced cardiac contractility.

Fórmula: C₂₉H₄₂O₁₀

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 550.64 g/mol

Ref: 3D-FC137904

Convallatoxin

Produto Controlado

CAS: 508-75-8

Applications Convallatoxin is a cardenolide that is used in the treatment of congestive heart failure. It may also be used in the treatment of tumor cells at nanomolar concentrations due to its anti-proliferative effects; in particular, human lung cancer. It is naturally found in the roots of Adonis Amurensis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schneider, N., et al.: Nat. Prod. Res., (2015); Yin, L., et al.: Zhong Cao Yao, 45, 3361 (2014);

Fórmula: C₂₉H₄₂O₁₀

Cor e Forma: White To Off-White

Peso molecular: 550.64

Ref: TR-C685075