CAS 508-77-0

Cimarina

Descrição:

Cimarina, com o número CAS 508-77-0, é um composto químico classificado como um glicosídeo cardíaco, derivado principalmente da espécie vegetal Digitalis purpurea, comumente conhecida como dedaleira. Apresenta uma estrutura caracterizada por um núcleo esteroide com um anel de lactona, que é típico dos glicosídeos. Cimarina é conhecido por seus efeitos farmacológicos, particularmente sua capacidade de influenciar a função cardíaca, aumentando a força das contrações do coração e regulando o ritmo cardíaco, tornando-o relevante no tratamento de certas condições cardíacas. O composto atua inibindo a enzima Na+/K+ ATPase, levando ao aumento dos níveis de cálcio intracelular nas células cardíacas. Além de seus usos terapêuticos, Cimarina pode ser tóxico em doses elevadas, levando a sintomas como náuseas, vômitos e arritmias. Seu uso é cuidadosamente monitorado em ambientes clínicos, e é essencial considerar as possíveis interações com outros medicamentos. No geral, Cimarina exemplifica a dupla natureza de muitos compostos naturais, oferecendo tanto benefícios terapêuticos quanto riscos.

Fórmula: C₃₀H₄₄O₉

InChI: InChI=1/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22+,23+,25+,26-,27-,28+,29+,30+/m1/s1

Chave InChI: InChIKey=XQCGNURMLWFQJR-ZNDDOCHDSA-N

SMILES: C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@]1(O)C[C@@H](O[C@H]6C[C@H](OC)[C@H](O)[C@@H](C)O6)CC2)[H])[H]

Sinónimos:

• (3beta,5beta)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta)-3-[(2,6-dideoxy-3-O-methylhexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,8alpha)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,8xi,9xi,10xi,13xi,14xi,17xi)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3β,5β)-3-[(2,6-Dideoxy-3-O-methyl-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Alvonal MR
• Card-20(22)-enolide, 3-[(2,6-dideoxy-3-O-methyl-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• Cymarine
• K-Strophanthin-α
• NSC 7522
• Strophantin K
• WV 90043a
• (+)-Cymarin
• Card-20(22)-enolide, 3-[(2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• (3β,5β)-3-[(2,6-Dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Cymarin
• (3beta,5beta)-3-[(2,6-dideoxy-4-O-beta-D\-glucopyranosyl-3-O-methyl-beta-D\-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• KOMBETIN
• STROPHANTHIN K
• CYMARIN: TECH., 90%
• K-STROPHANTHIN-ALPHA
• strofantidinacimaroside
• K-STROPHANTHIDIN-D-CYMAROSIDE
• 3β-[(3-O-Methyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide
• CIMARIN
• K STROPHANTHIN
• CYMARIN CRYSTALLINE
• CYMARIN(P)
• 5-beta-card-20(22)-enolide,3-beta-(beta-d-cymarosyloxy)-5,14-dihydroxy-19-ox
• alvonalmr
• 3β-[(2,6-Dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β,14β-card-20(22)-enolide

Cymarin

CAS: 508-77-0

Cymarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₃₀H₄₄O₉

Pureza: (HPLC) ≥90%

Cor e Forma: Powder

Peso molecular: 548.67

Ref: 11-0809

Cymarin

CAS: 508-77-0

Natural glycoside

Fórmula: C₃₀H₄₄O₉

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 548.68

Ref: 5G-89838

Cymarin

Produto Controlado

CAS: 508-77-0

Applications Cymarin is a pure allelochemicals that is a potent growth inhibitor in plants.
References Akhtar, Y.,e t al.: J. Appl. Entomol., 128, 32 (2004);

Fórmula: C₃₀H₄₄O₉

Cor e Forma: Neat

Peso molecular: 548.66

Ref: TR-C989908

Cymarin

CAS: 508-77-0

Cymarin is a cardiac glycoside, which is a class of organic compounds commonly derived from certain plant species, notably within the family Apocynaceae. It is extracted primarily from the plant *Apocynum cannabinum* and related species. Cymarin functions by inhibiting the sodium-potassium ATPase pump on cellular membranes. This inhibition leads to an increase in intracellular sodium levels, which in turn affects calcium exchange and enhances cardiac muscle contraction. This mode of action makes it a potent inotropic agent.

Fórmula: C₃₀H₄₄O₉

Pureza: Min. 95%

Peso molecular: 548.66 g/mol

Ref: 3D-FC156960

Cymarin

CAS: 508-77-0

Cymarin is a natural product for research related to life sciences. The catalog number is TN3746 and the CAS number is 508-77-0.

Fórmula: C₃₀H₄₄O₉

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 548.67

Ref: TM-TN3746