CAS 51-21-8

5-Fluorouracilo

Descrição:

5-Fluorouracilo (5-FU) é um análogo sintético de pirimidina que atua como um antimetabólito no tratamento do câncer, visando principalmente células que se dividem rapidamente. Sua fórmula química é C4H3FN2O2, e é caracterizada pela presença de um átomo de flúor na posição 5 do anel de uracila, o que altera suas vias metabólicas. O 5-FU é tipicamente administrado por via intravenosa ou tópica, dependendo do tipo de câncer que está sendo tratado, como câncer colorretal, de mama e de pele. O mecanismo de ação envolve a inibição da timidilato sintase, levando a uma depleção de trifosfato de timidina e, em última análise, interrompendo a síntese e reparo do DNA. 5-Fluorouracilo é conhecido por seus efeitos colaterais, que podem incluir distúrbios gastrointestinais, mielossupressão e mucosite, devido ao seu impacto nas células normais que se dividem rapidamente. Sua eficácia pode ser aumentada quando usada em combinação com outros agentes quimioterápicos. Como um potente agente quimioterápico, o 5-FU continua sendo um componente crítico na farmacoterapia oncológica.

Fórmula: C₄H₃FN₂O₂

InChI: InChI=1/C4H3FN2O2/c5-7-2-1-3(8)6-4(7)9/h1-2H,(H,6,8,9)

Chave InChI: InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N

SMILES: O=C1C(F)=CNC(=O)N1

Sinónimos:

• 1-fluoropyrimidine-2,4(1H,3H)-dione
• 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
• 2,4-Dihydroxy-5-fluoropyrimidine
• 2,4-Dioxo-5-fluoropyrimidine
• 5-Fluoracyl
• 5-Fluoro Uracil
• 5-Fluoro-1H-pyrimidine-2,4-dione
• 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• 5-Fluoro-2,4-(1H,3H)-pyrimidindion
• 5-Fluoro-2,4-Pyrimidinedione
• 5-Fluoro-2,4-dihydroxypyrimidine
• 5-Fluoropyrimidine-2,4-Dione
• 5-Fluoropyrimidine-2,4-diol
• 5-Fluoruracil
• 5-Fu
• 5-Oncouracil
• Adrucil
• Arumel
• Carac
• Carzonal
• Efudex
• Efudix
• Efurix
• FU
• Fluoracil
• Fluoroblastin
• Fluoroplex
• Fluorouracil
• Fluorouracil, 5-
• Fluorouracile
• Fluorouracile Accord
• Fluorouracilo
• Fluorouracilum
• Fluoruracil
• Flurablastin
• Fluracedyl
• Fluracil
• Fluracilum
• Fluri
• Fluril
• Ftoruracil
• Kecimeton
• Nsc 19893
• Phthoruracil
• Phtoruracil
• Queroplex
• Ro 2-9757
• Sigma 03738
• Tegadifure
• Timazin
• U 8953
• Ulup
• Uracil, 5-Fluoro-
• 5-faracil
• 3h)-pyrimidinedione,5-fluoro-4(1h
• 5-FLUOROURACIL
• 5-Fluor-2,4-dihydroxypyrimidin
• 1-FLUORO-1H-PYRIMIDINE-2,4-DIONE
• 5-FLUOROPYRIMIDINE-2,4(1H,3H)-DIONE
• 5-fluor-2,4(1h,3h)-pyrimidindion
• [180]-5-Fluorouracil

5-Fluorouracil

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Pureza: >99.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 130.08

Ref: 3B-F0151

5-Fluorouracil, 99%

CAS: 51-21-8

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses

Fórmula: C₄H₃FN₂O₂

Pureza: 99%

Cor e Forma: Crystalline powder, White to pale cream

Peso molecular: 130.08

Ref: 02-A13456

Flucytosine EP Impurity A

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Peso molecular: 130.1

Ref: ST-EA-CP-F3001

Fluorouracil

CAS: 51-21-8

Cor e Forma: Neat

Ref: 61-FOR0593.00

Fluorouracil

CAS: 51-21-8

Fluorouracil

Cor e Forma: White

Ref: 47-995

FLUOROURACIL RS

CAS: 51-21-8

FLUOROURACIL RS

Fórmula: C₄H₃FN₂O₂

Peso molecular: 130.0772

Ref: 41-ICRS0312

FLUOROURACIL CRS

CAS: 51-21-8

FLUOROURACIL CRS

Cor e Forma: Added Modified

Ref: 41-F0250000

Fluorouracil

CAS: 51-21-8

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Fórmula: C₄H₃FN₂O₂

Cor e Forma: White Off-White Powder

Peso molecular: 130.01786

Ref: 45-1279000

5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 130.0772

Ref: IN-DA003MRU

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis.

Fórmula: C₄H₃FN₂O₂

Pureza: 98% - >99.99%

Cor e Forma: White To Practically White Crystalline Powder Neoplastic Drug Chemosterilant For Insects (Epa 1998)

Peso molecular: 130.08

Ref: TM-T0984

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Pureza: ≥98%

Peso molecular: 130.08g/mol

Ref: 54-BUP17413

5-Fluorouracil

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Pureza: ≥ 99.0%

Cor e Forma: White to almost white crystalline powder

Peso molecular: 130.08

Ref: 7W-GP6168

Fluorouracil-13C-15N2

CAS: 51-21-8

Fórmula: C₃₁₃CH₃F₁₅N₂O₂

Cor e Forma: Pale Yellow Solid

Peso molecular: 133.06

Ref: 4Z-F-532

Fluorouracil

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Cor e Forma: White To Off-White Solid

Peso molecular: 130.08

Ref: 4Z-F-536

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Fórmula: C₄H₃FN₂O₂

Pureza: 99%

Cor e Forma: white solid

Peso molecular: 130.07722g/mol

Ref: 54-PC4380

5-Fluorouracil

Produto Controlado

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Cor e Forma: Neat

Peso molecular: 130.08

Ref: 04-C13799500

Fluorouracil

CAS: 51-21-8

Cor e Forma: Neat

Ref: 86-MM0593.00

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Fórmula: C₄H₃FN₂O₂

Pureza: 99%

Cor e Forma: white to almost white powder

Peso molecular: 130.07722g/mol

Ref: 54-BIF0123

5-Fluoro Uracil

Produto Controlado

CAS: 51-21-8

Impurity Flucytosine EP Impurity A
Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);

Fórmula: C₄H₃FN₂O₂

Cor e Forma: White

Peso molecular: 130.08

Ref: TR-F596000

5-Fluorouracil - Bio-X ™

CAS: 51-21-8

5-Fluorouracil is a cytotoxic drug that inhibits the synthesis of DNA. It is used in combination therapy to treat cancer and is a pyrimidine analog. This drug inhibits the formation of thymidylate synthase from uracil. As a result, this leads to DNA and RNA synthesis inhibition and cell death.

Fórmula: C₄H₃FN₂O₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 130.08 g/mol

Ref: 3D-BF166014

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil is a cytotoxic drug used to treat cancer. It is a prodrug that is converted to 5-fluoro-2'-deoxyuridine 5'-triphosphate (5-FUdR) in cells, and inhibits RNA synthesis by interacting with the enzyme thymidylate synthase. This drug has minimal toxicity in humans and has shown promising results against wild-type strains of bacteria. 5-Fluorouracil also has demonstrated synergistic activity when combined with the taxane docetaxel in the treatment of non-small cell lung cancer. 5-Fluorouracil's oral prodrug, fluorouracil, can be administered as an alternative to intravenous administration. The drug is found in many pharmaceutical preparations, including benzalkonium chloride wipes, which are used as topical agents for skin disinfection before surgery or other medical procedures. Blood samples may be drawn from patients who have been

Fórmula: C₄H₃FN₂O₂

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 130.08 g/mol

Ref: 3D-FF05372

5-Fluorouracil

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 130.078

Ref: 10-F003241

5-Fluorouracil (5-FU) Exiplus, Multi-Compendial, 99%

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Pureza: min. 99%

Cor e Forma: White to off white, Crystalline powder, Clear, Colourless

Peso molecular: 130.08

Ref: SR-59333

5-Fluorouracil (5-FU) extrapure, 99%

CAS: 51-21-8

Fórmula: C₄H₃FN₂O₂

Pureza: min. 99%

Cor e Forma: White to off white, Crystalline powder, Clear, Colourless

Peso molecular: 130.08

Ref: SR-15088