CAS 51773-92-3

Cloridrato de mefloquina

Descrição:

Cloridrato de mefloquina é um medicamento antimalárico utilizado principalmente para a prevenção e tratamento da malária, particularmente em áreas onde a resistência a outros medicamentos antimaláricos é prevalente. É um composto sintético que pertence à classe das quinolinas e é caracterizado por sua capacidade de interferir no crescimento do parasita da malária dentro das células vermelhas do sangue. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, o que facilita sua administração na forma oral. Cloridrato de mefloquina tem uma meia-vida relativamente longa, permitindo a dosagem uma vez por semana em regimes profiláticos. No entanto, está associado a uma série de efeitos colaterais potenciais, incluindo sintomas neuropsiquiátricos, que podem limitar seu uso em certas populações. O mecanismo de ação do composto envolve a inibição da polimerização de heme, levando ao acúmulo de heme tóxico dentro do parasita. Devido ao seu perfil farmacológico específico, Cloridrato de mefloquina continua sendo uma opção importante na luta global contra a malária, especialmente em regiões endêmicas.

Fórmula: C₁₇H₁₆F₆N₂O·ClH

InChI: InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s2

Chave InChI: InChIKey=WESWYMRNZNDGBX-HFEUSWDWNA-N

SMILES: C(F)(F)(F)C=1C2=C(C([C@H](O)[C@]3(CCCCN3)[H])=CC(C(F)(F)F)=N2)C=CC1.Cl

Sinónimos:

• (2R)-(+/-)-alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
• (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride (1:1)
• 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1), (αS)-rel-
• 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (αS)-rel-
• 4-Quinolinemethanol, α-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (R*,S*)-
• Loriam
• Mefloquin hydrochloride
• Mefloquine Hcl
• NSC 157387
• Ro 21-5998/001
• Wr 142490
• [2,8-Bis(Trifluoromethyl)Quinolin-4-Yl](Piperidin-2-Yl)Methanol Hydrochloride (1:1)

Mefloquine Hydrochloride

CAS: 51773-92-3, 53230-10-7

Fórmula: C₁₇H₁₆F₆N₂O·HCl

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 414.78

Ref: 3B-M2313

Mefloquine Hydrochloride

CAS: 51773-92-3

Cor e Forma: Neat

Ref: 61-FOR1198.00

MEFLOQUINE FOR SYSTEM SUITABILITY CRS

CAS: 51773-92-3

MEFLOQUINE FOR SYSTEM SUITABILITY CRS

Cor e Forma: Modified

Ref: 41-Y0002421

MEFLOQUINE HYDROCHLORIDE CRS

CAS: 51773-92-3

MEFLOQUINE HYDROCHLORIDE CRS

Fórmula: C₁₇H₁₆F₆N₂O

Cor e Forma: Added Modified

Peso molecular: 378.3122

Ref: 41-M0253000

Mefloquine Hydrochloride

CAS: 51773-92-3

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₁₇H₁₆F₆N₂O·HCl

Cor e Forma: White Powder

Peso molecular: 378.11668

Ref: 45-1379059

4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel-

CAS: 51773-92-3

Fórmula: C₁₇H₁₇ClF₆N₂O

Pureza: %

Cor e Forma: Solid

Peso molecular: 414.7731

Ref: IN-DA00I991

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

Fórmula: C₁₇H₁₇ClF₆N₂O

Pureza: 99% - 99.99%

Cor e Forma: Off-White To Yellow Solid

Peso molecular: 414.77

Ref: TM-T0860

(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride

CAS: 51773-92-3

(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride

Fórmula: C₁₇H₁₆F₆N₂O·ClH

Pureza: 99%

Cor e Forma: white powder

Peso molecular: 414.77g/mol

Ref: 54-PC404546

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine hydrochloride

Pureza: ≥98%

Peso molecular: 414.77g/mol

Ref: 54-BUP13994

Mefloquine HCl

CAS: 51773-92-3

Fórmula: C₁₇H₁₆F₆N₂O·HCl

Peso molecular: 378.32 36.46

Ref: 4Z-M-821

Mefloquine hydrochloride, BP, Ph. Eur., USP grade

CAS: 51773-92-3

Fórmula: C₁₇H₁₆F₆N₂O·HCl

Peso molecular: 414.77

Ref: 7W-GP0681

Mefloquine hydrochloride

CAS: 51773-92-3

Fórmula: C₁₇H₁₆F₆N₂O·HCl

Pureza: ≥ 98.0%

Cor e Forma: White to pale yellow crystalline powder

Peso molecular: 414.77

Ref: 7W-GP7880

Mefloquine hydrochloride 100 µg/mL in Acetonitrile

CAS: 51773-92-3

Fórmula: C₁₇H₁₆F₆N₂O·ClH

Cor e Forma: Single Solution

Peso molecular: 414.77

Ref: 04-A14860900AL-100

Mefloquine Hydrochloride

CAS: 51773-92-3

Fórmula: C₁₇H₁₆F₆N₂O·ClH

Cor e Forma: Neat

Peso molecular: 414.77

Ref: 86-MM1198.00

Mefloquine Hydrochloride (d10 Major)

Produto Controlado

CAS: 51773-92-3

Applications Labelled quinoline methanol antimalarial agent.
References Carroll, F.I., et al.: J. Med. Chem., 17, 210 (1974), Davidson, M.W., et al.: J. Med. Chem., 20, 1117 (1977), Brown, R.E., et al.: Life Sci., et al.: 25, 1857 (1979), Lim, P., et al.: Anal. Profiles Drug Subs., 14, 157 (1985),

Fórmula: C₁₇₂H₁₀H₆F₆N₂O·ClH

Cor e Forma: Neat

Peso molecular: 424.83

Ref: TR-M207053

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine is a drug that belongs to the class of pharmacological agents. It is used in the treatment of malaria caused by protozoa of the genus Plasmodium, which are transmitted by mosquitoes. Mefloquine is a metal chelate that inhibits the activity of p-glycoprotein, a membrane protein which controls the transport or efflux of many drugs from cells. This inhibition leads to an increase in the concentration of mefloquine inside bacteria and parasites, increasing its effectiveness at inhibiting their growth. Mefloquine has been shown to be effective in treating infectious diseases such as bowel disease and malaria caused by protozoa.
Mefloquine can cause toxic epidermal necrolysis, a condition where large areas of skin slough off and die if taken with certain other drugs (such as phenytoin).

Fórmula: C₁₇H₁₇ClF₆N₂O

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 414.77 g/mol

Ref: 3D-FP40600

Mefloquine hydrochloride

CAS: 51773-92-3

Fórmula: C₁₇H₁₇ClF₆N₂O

Pureza: 95.0%

Peso molecular: 414.78

Ref: 10-F091687